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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prrx1
paired related homeobox 1
MGI:97712
69 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prrx1tm1Bhr/Prrx1tm1Bhr
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 		abnormal long bone hypertrophic chondrocyte zone J:131364
abnormal trabecular bone morphology J:131364
decreased width of hypertrophic chondrocyte zone J:131364
long limbs J:131364
Prrx1tm1Jfm/Prrx1tm1Jfm
involves: 129S4/SvJae 		short limbs J:131364
Prrx1tm1Jfm/Prrx1tm1Jfm
involves: 129S4/SvJaeSor 		abnormal lung vasculature morphology J:99153
cyanosis J:99153
decreased body size J:99153
neonatal lethality, complete penetrance J:99153
pulmonary hypoplasia J:99153
respiratory distress J:99153
Prrx1tm1Jfm/Prrx1tm1Tex
involves: 129S4/SvJaeSor * 129S7/SvEvBrd 		abnormal cranium morphology J:51596
abnormal long bone morphology J:51596
abnormal respiration J:51596
neonatal lethality J:51596
Prrx1tm1Tex/Prrx1tm1Tex
involves: 129S7/SvEvBrd 		abnormal aortic arch morphology J:60507
abnormal artery morphology J:60507
abnormal cartilage morphology J:25649
abnormal fetal ductus arteriosus morphology J:60507
abnormal forelimb zeugopod morphology J:50488
abnormal hindlimb zeugopod morphology J:50488
abnormal incudostapedial joint morphology J:25649
abnormal incus morphology J:25649
abnormal long bone morphology J:25649
abnormal malleus manubrium morphology J:25649
abnormal malleus morphology J:25649, J:50488
abnormal malleus processus brevis morphology J:25649
abnormal mandible morphology J:25649
abnormal Meckel's cartilage morphology J:25649, J:51596
abnormal metacarpal bone morphology J:50488
abnormal middle ear ossicle morphology J:25649
abnormal palatal shelf fusion at midline J:25649
abnormal pulmonary trunk morphology J:60507
abnormal stapes crus morpholgy J:25649
abnormal stapes morphology J:25649
abnormal stylohyoid ligament morphology J:50488
abnormal thoracic vertebrae morphology J:25649
abnormal tibia morphology J:25649
abnormal vertebrae morphology J:50488
absent alisphenoid bone J:25649
absent gonial bone J:25649
absent maxillary shelf J:25649
absent palatine bone horizontal plate J:25649
absent stapes obturator foramen J:25649
absent supraoccipital bone J:25649
absent temporal bone squamous part J:25649, J:50488
absent temporomandibular joint J:25649
absent tympanic ring J:25649
absent zygomatic bone J:25649, J:50488
alisphenoid bone hypoplasia J:25649
aphagia J:25649
bowed radius J:25649
bowed tibia J:25649
cleft secondary palate J:25649, J:50488
cyanosis J:25649
delayed bone ossification J:25649
distended abdomen J:25649
lowered ear position J:25649
mandible hypoplasia J:25649
maxillary shelf hypoplasia J:50488, J:51596
microcephaly J:25649
neonatal lethality, complete penetrance J:25649, J:50488, J:60507
pointed snout J:25649
pterygoid bone hypoplasia J:25649
respiratory distress J:25649
short fibula J:25649
short malleus manubrium J:25649
short radius J:25649
short tibia J:25649
short ulna J:25649
small otic capsule J:50488
spina bifida J:25649, J:50488
Prrx1tm2Bhr/Prrx1tm2Bhr
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 		normal limbs/digits/tail phenotype J:131364
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory