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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Polb
polymerase (DNA directed), beta
MGI:97740
86 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Polbtm1.1Jbsw/Polb+
involves: 129/Sv * C57BL/6 		dermatitis J:206872
enlarged cervical lymph nodes J:206872
enlarged salivary gland J:206872
glomerulonephritis J:206872
increased anti-nuclear antigen antibody level J:206872
increased IgG level J:206872
lymph node inflammation J:206872
salivary gland inflammation J:206872
Polbtm1.1Jbsw/Polbtm1.1Jbsw
involves: 129/Sv * C57BL/6 		abnormal base-excision repair J:183837
abnormal cell cycle J:183837
abnormal immunoglobulin heavy chain V(D)J recombination J:206872
abnormal somatic hypermutation frequency J:206872
abnormal spleen germinal center morphology J:206872
chromosomal instability J:183837
decreased birth weight J:183837
decreased body size J:183837
decreased cell proliferation J:183837
decreased fibroblast proliferation J:183837
dermatitis J:206872
enlarged cervical lymph nodes J:206872
enlarged salivary gland J:206872
glomerulonephritis J:206872
increased anti-nuclear antigen antibody level J:206872
increased embryonic tissue cell apoptosis J:183837
increased germinal center B cell number J:206872
increased hepatocyte apoptosis J:183837
increased IgG level J:206872
increased kidney apoptosis J:183837
increased neuron apoptosis J:183837
increased sensitivity to induced cell death J:183837
increased spleen germinal center number J:206872
increased splenocyte apoptosis J:183837, J:206872
increased susceptibility to systemic lupus erythematosus J:206872
increased T-helper 2 cell number J:206872
lymph node inflammation J:206872
neonatal lethality, incomplete penetrance J:183837
salivary gland inflammation J:206872
Polbtm1.1Rsky/Polbtm1.1Rsky
involves: 129P2/OlaHsd 		perinatal lethality, complete penetrance J:67942
prenatal lethality, incomplete penetrance J:67942
Polbtm1a(KOMP)Wtsi/Polb+
C57BL/6N-Polbtm1a(KOMP)Wtsi/Wtsi 		decreased total body fat amount J:211773
increased lean body mass J:211773
increased mean platelet volume J:211773
Polbtm1a(KOMP)Wtsi/Polbtm1a(KOMP)Wtsi
C57BL/6N-Polbtm1a(KOMP)Wtsi/Wtsi 		abnormal brain internal capsule morphology J:239583
abnormal cerebral cortex morphology J:239583
abnormal cervical atlas morphology J:239583
abnormal cervical rib J:239583
abnormal cervical vertebrae morphology J:239583
abnormal direction of heart looping J:239583
abnormal eye muscle morphology J:239583
abnormal forebrain morphology J:239583
abnormal hindbrain morphology J:239583
abnormal hypoglossal nerve topology J:239583
abnormal interatrial septum morphology J:239583
abnormal lymphatic vessel topology J:239583
abnormal optic cup morphology J:239583
abnormal vagus ganglion morphology J:239583
abnormal vertebral artery topology J:239583
abnormal vitelline vein connection J:239583
abnormal Wolffian duct connection J:239583
abnormal Wolffian duct topology J:239583
absent extracranial vertebral artery segment J:239583
absent stapedial artery J:239583
adrenal gland hypoplasia J:239583
dermal cyst J:239583
dorsal root ganglion hyperplasia J:239583
dorsal root ganglion hypoplasia J:239583
eye hemorrhage J:239583
fusion of vertebral arches J:239583
increased trigeminal neuroma incidence J:239583
inverse situs of great intrathoracic arteries J:239583
persistent trigeminal artery J:239583
preweaning lethality, complete penetrance J:211773
reduced sympathetic cervical ganglion size J:239583
retroesophageal left subclavian artery J:239583
small superior cervical ganglion J:239583
small superior vagus ganglion J:239583
small thyroid gland J:239583
subcutaneous edema J:239583
thin facial nerve J:239583
thin hypoglossal nerve J:239583
thin motoric part of trigeminal nerve J:239583
thin oculomotor nerve J:239583
thin splanchnic nerve J:239583
Polbtm1Koy/Polbtm1Koy
involves: 129P2/OlaHsd * C57BL/6 		abnormal neuron differentiation J:61143
abnormal pulmonary alveolus morphology J:61143
abnormal reflex J:61143
atelectasis J:61143
cyanosis J:61143
embryonic growth retardation J:61143
increased neuron apoptosis J:61143
neonatal lethality, complete penetrance J:61143
pallor J:61143
respiratory failure J:61143
thin cerebral cortex J:61143
Polbtm1Rsky/Polbtm1Rsky
Tg(Lck-cre)I57Jxm/0
involves: 129P2/OlaHsd * ICR 		normal immune system phenotype J:67942
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory