Pold1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pold1
polymerase (DNA directed), delta 1, catalytic subunit
MGI:97741

26 phenotypes from 8 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pold1^tm1.1Bdp/Pold1^tm1.1Bdp B6.129-Pold1^tm1.1Bdp	increased intestinal adenocarcinoma incidence	J:153684
	increased intestinal adenoma incidence	J:153684
	increased lung tumor incidence	J:153684
	increased lymphoma incidence	J:153684
	increased skin tumor incidence	J:153684
	increased T cell derived lymphoma incidence	J:153684
	premature death	J:153684
Pold1^tm1.1Uchi/Pold1^tm1.1Uchi C57BL/6-Pold1^tm1.1Uchi	normal embryo phenotype	J:144992
	enlarged thymus	J:144992
	increased tumor incidence	J:144992
	premature death	J:144992
Pold1^tm1Bdp/Pold1^tm1Bdp involves: 129S1/Sv * 129X1/SvJ * C57BL/6	increased lung adenocarcinoma incidence	J:100685
	increased lymphoma incidence	J:80306, J:100685
	increased sarcoma incidence	J:100685
	increased skin tumor incidence	J:80306
	increased squamous cell carcinoma incidence	J:100685
	increased T cell derived lymphoma incidence	J:100685
	increased tumor incidence	J:80306, J:100685
	premature death	J:80306
Pold1^tm1Loeb/Pold1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	cardiomyopathy	J:129046
	premature death	J:129046
Pold1^tm1Loeb/Pold1^tm1Loeb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:129046
Pold1^tm1Uchi/Pold1^tm1.1Uchi C57BL/6-Pold1^tm1Uchi/Pold1^tm1.1Uchi	normal embryo phenotype	J:144992
	enlarged thymus	J:144992
	increased tumor incidence	J:144992
	premature death	J:144992
Pold1^tm1Uchi/Pold1^tm1Uchi C57BL/6-Pold1^tm1Uchi	abnormal trophoblast layer morphology	J:144992
	absent inner cell mass proliferation	J:144992
	embryonic lethality between implantation and somite formation, complete penetrance	J:144992
	inner cell mass degeneration	J:144992
Pold1^tm2Loeb/Pold1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	increased tumor incidence	J:129046
	premature death	J:129046
Pold1^tm2Loeb/Pold1^tm2Loeb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	embryonic lethality between somite formation and embryo turning, complete penetrance	J:129046
Pold1^tyrn/Pold1^{tm1b(EUCOMM)Wtsi} involves: C57BL/6J * C57BL/6N	embryonic lethality between implantation and somite formation, complete penetrance	J:327432
Pold1^tyrn/Pold1^tyrn C57BL/6J-Pold1^tyrn	abnormal embryonic tissue morphology	J:327432
	decreased cell proliferation	J:327432
	decreased embryo size	J:327432
	normal embryo phenotype	J:327432
	increased embryonic tissue cell apoptosis	J:327432
Pold1^tyrn/Pold1^tyrn Tg(Hhex-EGFP)#Rbe/0 involves: C57BL/6 * C57BL/6J * CBA/J	abnormal allantois morphology	J:327432
	abnormal primitive streak elongation	J:327432
	normal embryo phenotype	J:327432

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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