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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pomc
pro-opiomelanocortin-alpha
MGI:97742
77 phenotypes from 8 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pomcem1(IMPC)Rbrc/Pomc+
C57BL/6NJcl-Pomcem1(IMPC)Rbrc/Rbrc 		abnormal spleen morphology J:211773
enlarged spleen J:211773
impaired glucose tolerance J:211773
Pomcem1(IMPC)Rbrc/Pomcem1(IMPC)Rbrc
C57BL/6NJcl-Pomcem1(IMPC)Rbrc/Rbrc 		preweaning lethality, incomplete penetrance J:211773
Pomctm1.1Kgm/Pomctm1.1Kgm
involves: C57BL/6J 		decreased oxygen consumption J:263640
normal homeostasis/metabolism phenotype J:263640
increased body fat mass J:263640
increased body length J:263640
increased body weight J:263640
polyphagia J:263640
Pomctm1Low/Pomc+
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 		increased pituitary adenoma incidence J:119240
Pomctm1Low/Pomc+
Tg(Pomc)#Low/0
involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster 		increased pituitary adenoma incidence J:119240
Pomctm1Low/Pomctm1Low
B6.129S2-Pomctm1Low 		abnormal alcohol consumption J:49706
abnormal behavior J:122110
abnormal neuron physiology J:113139
abnormal operant conditioning behavior J:49706
abnormal response/metabolism to endogenous compounds J:115712
normal adipose tissue phenotype J:115712
normal homeostasis/metabolism phenotype J:115712
hyperactivity elicited by ethanol administration J:49706
impaired conditioned place preference behavior J:122110
impaired glucose tolerance J:115712
increased alcohol consumption J:49706
increased body weight J:113139, J:115712
increased circulating insulin level J:115712
increased circulating leptin level J:115712
increased fat cell size J:115712
increased gonadal fat pad weight J:115712
increased inguinal fat pad weight J:115712
increased physiological sensitivity to xenobiotic J:115712
increased renal fat pad weight J:115712
increased retroperitoneal fat pad weight J:115712
increased systemic arterial systolic blood pressure J:113139
increased total body fat amount J:115712
increased urine adrenaline level J:113139
obese J:115712
polyphagia J:115712
Pomctm1Low/Pomctm1Low
B6.129S2-Pomctm1Low/J 		normal behavior/neurological phenotype J:84463
increased aggression towards mice J:84463
increased body weight J:84463
increased circulating corticosterone level J:84463
Pomctm1Low/Pomctm1Low
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 		obese J:115712
Pomctm1Low/Pomctm1Low
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 		decreased adrenal gland zona fasciculata size J:119240
decreased adrenocorticotropin level J:119240
decreased circulating adrenocorticotropin level J:119240
decreased circulating corticosterone level J:119240
disorganized adrenal gland zona fasciculata J:119240
increased pituitary adenoma incidence J:119240
perinatal lethality, incomplete penetrance J:119240
small adrenal glands J:119240
Pomctm1Low/Pomctm1Low
involves: 129S2/SvPas * C57BL/6 		decreased circulating adrenocorticotropin level J:102955
decreased circulating corticosterone level J:102955
increased circulating interleukin-6 level J:102955
increased interleukin-6 secretion J:102955
increased splenocyte proliferation J:102955
increased tumor necrosis factor secretion J:102955
Pomctm1Low/Pomctm1Low
involves: 129S2/SvPas * C57BL/6 * Swiss albino 		obese J:115712
Pomctm1Low/Pomctm1Low
involves: 129S2/SvPas * C57BL/6N 		abnormal behavioral response to addictive substance J:47711
abnormal touch/ nociception J:47711
increased body weight J:47711
Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/0
involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster 		abnormal corticosterone level J:119240
decreased adrenocorticotropin level J:119240
decreased circulating adrenocorticotropin level J:119240
enlarged adrenal glands J:119240
increased adrenal gland zona fasciculata size J:119240
increased body weight J:119240
increased circulating adrenocorticotropin level J:119240
increased circulating corticosterone level J:119240
increased pituitary adenoma incidence J:119240
normal mortality/aging J:119240
Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/Tg(Pomc)#Low
involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster 		increased body weight J:119240
increased circulating corticosterone level J:119240
Pomctm1Sora/Pomc+
involves: 129S2/SvHsd * 129S6/SvEvTac 		decreased circulating corticosterone level J:89244
diluted coat color J:89244
increased susceptibility to diet-induced obesity J:89244
normal integument phenotype J:89244
Pomctm1Sora/Pomctm1Sora
involves: 129S2/SvHsd * 129S6/SvEvTac 		decreased circulating corticosterone level J:89244
decreased circulating thyroxine level J:89244
decreased oxygen consumption J:89244
decreased response to leptin J:89244
diluted coat color J:89244
increased susceptibility to diet-induced obesity J:89244
obese J:89244
polyphagia J:89244
Pomctm2.1Low/Pomctm2.1Low
B6.129S4(FVB)-Pomctm2.1Low 		normal behavior/neurological phenotype J:194013
normal growth/size/body region phenotype J:194013
Pomctm2Low/Pomctm2Low
B6.129S4-Pomctm2Low 		decreased compensatory feeding amount J:194013
decreased locomotor activity J:194013
decreased oxygen consumption J:194013
hepatic steatosis J:194013
increased circulating glucose level J:194013
increased circulating insulin level J:194013
increased circulating leptin level J:194013
increased gonadal fat pad weight J:194013
increased inguinal fat pad weight J:194013
increased lean body mass J:194013
increased liver weight J:194013
increased retroperitoneal fat pad weight J:194013
increased total body fat amount J:194013
insulin resistance J:194013
obese J:194013
polyphagia J:194013
Pomctm2Low/Pomctm2Low
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal body weight J:194013
decreased compensatory feeding amount J:194013
decreased food intake J:194013
decreased locomotor activity J:194013
decreased oxygen consumption J:194013
hepatic steatosis J:194013
increased body length J:194013
increased body weight J:194013
increased circulating glucose level J:194013
increased circulating insulin level J:194013
increased circulating leptin level J:194013
increased gonadal fat pad weight J:194013
increased inguinal fat pad weight J:194013
increased lean body mass J:194013
increased liver weight J:194013
increased retroperitoneal fat pad weight J:194013
increased susceptibility to weight gain J:194013
increased total body fat amount J:194013
insulin resistance J:194013
polyphagia J:194013
Pomctm2Ute/Pomc+
involves: 129S1/Sv * 129X1/SvJ 		normal growth/size/body region phenotype J:57503
increased circulating leptin level J:57503
Pomctm2Ute/Pomctm2Ute
involves: 129S1/Sv * 129X1/SvJ 		absent adrenal gland J:57503
decreased circulating adrenaline level J:57503
decreased circulating adrenocorticotropin level J:57503
decreased circulating aldosterone level J:57503
decreased circulating corticosterone level J:57503
diluted coat color J:57503
increased body length J:57503
increased circulating leptin level J:57503
increased dopamine level J:57503
increased food intake J:57503
increased susceptibility to diet-induced obesity J:57503
obese J:57503
prenatal lethality, incomplete penetrance J:57503
yellow coat color J:57503
Tg(Pomc)#Low/0
involves: C57BL/6 * DBA/2 		normal endocrine/exocrine gland phenotype J:119240
normal growth/size/body region phenotype J:119240
normal homeostasis/metabolism phenotype J:119240
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/21/2024
MGI 6.24 		The Jackson Laboratory