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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pparg
peroxisome proliferator activated receptor gamma
MGI:97747
80 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atp2b2m1Mae/Atp2b2+
Ppargtm2Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6J 		abnormal prepulse inhibition J:110607
decreased startle reflex J:110607
impaired hearing J:110607
Atp2b2m1Mae/Atp2b2m1Mae
Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J 		abnormal blinking J:110607
abnormal gait J:110607
abnormal motor coordination/balance J:110607
abnormal prepulse inhibition J:110607
abnormal reflex J:110607
abnormal vibrissae reflex J:110607
absent pinna reflex J:110607
absent startle reflex J:110607
ataxia J:110607
decreased body size J:110607
decreased grip strength J:110607
head bobbing J:110607
impaired balance J:110607
impaired hearing J:110607
impaired righting response J:110607
postnatal growth retardation J:110607
tremors J:110607
Ctnnb1tm1Mmt/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		abnormal osteoclast differentiation J:178340
abnormal trabecular bone morphology J:178340
absent bone marrow cell J:178340
decreased bone marrow cell number J:178340
decreased bone resorption J:178340
decreased osteoclast cell number J:178340
extramedullary hematopoiesis J:178340
increased bone trabecula number J:178340
increased bone volume J:178340
increased compact bone volume J:178340
increased splenocyte number J:178340
increased trabecular bone thickness J:178340
increased trabecular bone volume J:178340
osteopetrosis J:178340
normal skeleton phenotype J:178340
Ctnnb1tm2Kem/Ctnnb1+
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal osteoclast physiology J:178340
abnormal trabecular bone morphology J:178340
decreased bone trabecula number J:178340
decreased trabecular bone mass J:178340
decreased trabecular bone thickness J:178340
decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
normal skeleton phenotype J:178340
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal osteoclast physiology J:178340
abnormal trabecular bone morphology J:178340
decreased bone resorption J:178340
decreased osteoclast cell number J:178340
extramedullary hematopoiesis J:178340
increased bone trabecula number J:178340
increased bone volume J:178340
increased compact bone volume J:178340
increased trabecular bone thickness J:178340
increased trabecular bone volume J:178340
osteopetrosis J:178340
normal skeleton phenotype J:178340
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Tg(tetO-HIST1H2BJ/GFP)47Efu/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 		abnormal osteoclast differentiation J:178340
Dok1tm1Yyam/Dok1tm1Yyam
Ppargtm1Laz/Ppargtm1Laz
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal fat cell morphology J:133566
normal adipose tissue phenotype J:133566
Lepob/Lepob
Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6 		abnormal glucose homeostasis J:116568
abnormal gonadal fat pad morphology J:116568
abnormal skeletal muscle morphology J:116568
abnormal white adipose tissue amount J:116568
decreased body fat mass J:116568
decreased body weight J:116568
decreased circulating adiponectin level J:116568
decreased fat cell size J:116568
hepatic steatosis J:116568
increased circulating glucose level J:116568
increased circulating insulin level J:116568
increased circulating triglyceride level J:116568
increased liver weight J:116568
insulin resistance J:116568
polyphagia J:116568
Lepob/Lepob
Ppargtm2Avp/Ppargtm2Avp
involves: 129 * C57BL/6 		abnormal fat cell morphology J:121534
abnormal glucose homeostasis J:121534
abnormal insulin secretion J:121534
abnormal lipid homeostasis J:121534
abnormal liver morphology J:121534
abnormal locomotor behavior J:121534
abnormal pancreatic islet morphology J:121534
abnormal skeletal muscle morphology J:121534
decreased circulating adiponectin level J:121534
decreased circulating insulin level J:121534
decreased liver triglyceride level J:121534
decreased locomotor activity J:121534
decreased respiratory quotient J:121534
decreased triglyceride level J:121534
disorganized pancreatic islets J:121534
normal endocrine/exocrine gland phenotype J:121534
normal growth/size/body region phenotype J:121534
hepatic steatosis J:121534
hyperglycemia J:121534
increased circulating free fatty acids level J:121534
increased circulating glucose level J:121534
increased circulating insulin level J:121534
increased circulating triglyceride level J:121534
increased fluid intake J:121534
increased percent body fat/body weight J:121534
increased urine glucose level J:121534
insulin resistance J:121534
oxidative stress J:121534
polyphagia J:121534
Ppargtm1.1Unc/Pparg+
involves: 129S6/SvEvTac * C57BL/6J 		decreased systemic arterial blood pressure J:154767
Ppargtm1.1Unc/Ppargtm1.1Unc
involves: 129S6/SvEvTac * C57BL/6J 		decreased systemic arterial blood pressure J:154767
normal homeostasis/metabolism phenotype J:154767
impaired glucose tolerance J:154767
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory