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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prlr
prolactin receptor
MGI:97763
55 phenotypes from 2 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prlrtm1.1Skkm/Prlrtm1.1Skkm
Tg(Ins2-cre)23Herr/0
involves: C57BL/6J * CBA/J 		normal endocrine/exocrine gland phenotype J:284574
normal homeostasis/metabolism phenotype J:284574
Prlrtm1Cnp/Prlr+
B6.129P2-Prlrtm1Cnp/J 		abnormal neuron proliferation J:83248
Prlrtm1Cnp/Prlr+
either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 		abnormal lactation J:38093
abnormal mammary gland development J:38093
abnormal maternal nurturing J:38093
abnormal pup retrieval J:38093
Prlrtm1Cnp/Prlr+
involves: 129P2/OlaHsd 		abnormal hair cycle J:70207
abnormal maternal behavior J:83247
abnormal pup retrieval J:83247
normal behavior/neurological phenotype J:83247
normal taste/olfaction phenotype J:83247
Prlrtm1Cnp/Prlr+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal mammary gland development J:70408
Prlrtm1Cnp/Prlrtm1Cnp
either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 		abnormal decidualization J:38093
abnormal oogenesis J:38093
abnormal oviduct environment J:38093
abnormal reproductive system physiology J:38093
abnormal uterine environment J:38093
decreased ovulation rate J:38093
decreased primary ovarian follicle number J:38093
female infertility J:38093
increased mating frequency J:38093
male infertility J:38093
reduced male fertility J:38093
Prlrtm1Cnp/Prlrtm1Cnp
involves: 129/Sv * 129P2/OlaHsd 		abnormal thyroid gland morphology J:101609
decreased body temperature J:101609
decreased thyroxine level J:101609
normal homeostasis/metabolism phenotype J:85593
increased thyroid carcinoma incidence J:101609
normal reproductive system phenotype J:85593
Prlrtm1Cnp/Prlrtm1Cnp
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal bone mineralization J:52026
abnormal bone ossification J:52026
abnormal circulating calcium level J:52026
decreased bone mass J:52026
decreased circulating estradiol level J:52026
decreased circulating progesterone level J:52026
delayed bone ossification J:52026
increased circulating parathyroid hormone level J:52026
increased circulating prolactin level J:52026
Prlrtm1Cnp/Prlrtm1Cnp
involves: 129P2/OlaHsd 		abnormal coat/ hair morphology J:70207
abnormal hair cycle J:70207
abnormal maternal behavior J:83247
abnormal pup retrieval J:83247
normal behavior/neurological phenotype J:83247
coarse hair J:70207
decreased body weight J:95779
decreased bone mineral density J:95779
slow postnatal weight gain J:95779
normal taste/olfaction phenotype J:83247
Prlrtm1Cnp/Prlrtm1Cnp
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal Harderian gland morphology J:66544
abnormal Harderian gland porphyrin secretion J:66544
abnormal lacrimal gland morphology J:66544
abnormal prostate gland epithelium morphology J:84352
increased prostate gland ventral lobe weight J:84352
increased seminal vesicle weight J:84352
male infertility J:84352
reduced male fertility J:84352
normal vision/eye phenotype J:66544
Prlrtm1Cnp/Prlrtm1Cnp
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal pancreatic islet morphology J:106829
decreased abdominal fat pad weight J:67354
decreased body weight J:67354
decreased circulating leptin level J:67354
decreased insulin secretion J:106829
decreased pancreatic beta cell mass J:106829
impaired glucose tolerance J:106829
slow postnatal weight gain J:67354
small pancreatic islets J:106829
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory