Ptbp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptbp1
polypyrimidine tract binding protein 1
MGI:97791

27 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptbp1^tm1Msol/Ptbp1^tm1Msol B6J.129-Ptbp1^tm1Msol	abnormal ectoplacental cone morphology	J:223915
	abnormal endoderm development	J:223915
	abnormal gastrulation	J:223915
	abnormal Reichert's membrane morphology	J:223915
	abnormal visceral yolk sac morphology	J:223915
	absent blastocoele	J:223915
	decreased cell proliferation	J:223915
	decreased embryo size	J:223915
	embryonic growth retardation	J:223915
	embryonic lethality during organogenesis, complete penetrance	J:223915
	increased apoptosis	J:223915
Ptbp1^tm1Nobu/Ptbp1^tm1Nobu involves: 129P2/OlaHsd	embryonic lethality between implantation and somite formation, complete penetrance	J:213626
Ptbp1^tm1Nobu/Ptbp1^tm2Nobu Emx1^tm1(cre)Ito/Emx1⁺ involves: 129P2/OlaHsd	abnormal brain ependyma motile cilium morphology	J:213479
	abnormal telencephalon morphology	J:213479
	dilated lateral ventricle	J:213479
	hydrocephaly	J:213479
Ptbp1^tm1Nobu/Ptbp1^tm2Nobu Tg(Nes-cre)1Sasa/0 involves: 129P2/OlaHsd	abnormal brain ependyma morphology	J:213479
	abnormal lateral ventricle morphology	J:213479
	abnormal nervous system development	J:213479
	abnormal neuronal stem cell morphology	J:213479
	dilated lateral ventricle	J:213479
	domed cranium	J:213479
	ectopic neuron	J:213479
	increased astrocyte number	J:213479
	normal nervous system phenotype	J:213479
	non-obstructive hydrocephaly	J:213479
	premature death	J:213479
	premature neuronal precursor differentiation	J:213479
Ptbp1^tm1Nobu/Ptbp1^tm2Nobu Tg(Nes-cre/ERT2)#Kag/0 involves: 129P2/OlaHsd * C57BL/6	normal nervous system phenotype	J:213479

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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