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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptgs1
prostaglandin-endoperoxide synthase 1
MGI:97797
60 phenotypes from 3 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ptgs1em1(IMPC)Mbp/Ptgs1em1(IMPC)Mbp
C57BL/6NCrl-Ptgs1em1(IMPC)Mbp/MbpMmucd 		abnormal auditory brainstem response J:211773
abnormal cecum morphology J:211773
enlarged cecum J:211773
Ptgs1tm1Fun/Ptgs1tm1Fun
involves: 129S6/SvEvTac * C57BL/6 		abnormal thromboxane level J:108957
decreased inflammatory response J:97351
decreased platelet aggregation J:97351
decreased susceptibility to induced thrombosis J:97351
decreased urine prostaglandin level J:108957
increased bleeding time J:97351
normal reproductive system phenotype J:97351
Ptgs1tm1Unc/Ptgs1+
D1.129P2-Ptgs1tm1Unc 		normal growth/size/body region phenotype J:102779
increased prostaglandin level J:102779
Ptgs1tm1Unc/Ptgs1+
involves: 129P2/OlaHsd * C57BL/6 		decreased prostaglandin level J:29511
Ptgs1tm1Unc/Ptgs1+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased prostaglandin level J:106147
Ptgs1tm1Unc/Ptgs1tm1Unc
B6.129P2-Ptgs1tm1Unc 		abnormal drinking behavior J:125586
abnormal nociception after inflammation J:110716
abnormal response/metabolism to endogenous compounds J:125586
allodynia J:110716
decreased brain blood flow rate J:115589
decreased physiological sensitivity to xenobiotic J:115589
decreased susceptibility to induced arthritis J:110716
increased bronchoconstrictive response J:141201
increased thermal nociceptive threshold J:110716
Ptgs1tm1Unc/Ptgs1tm1Unc
B6;129P2-Ptgs1tm1Unc/Tac 		abnormal stomach pH J:103642
normal behavior/neurological phenotype J:141610
decreased digestive secretion J:103642
decreased physiological sensitivity to xenobiotic J:103642
normal homeostasis/metabolism phenotype J:112346
normal muscle phenotype J:107751
normal nervous system phenotype J:141610
Ptgs1tm1Unc/Ptgs1tm1Unc
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		normal homeostasis/metabolism phenotype J:124756
normal skeleton phenotype J:124756
Ptgs1tm1Unc/Ptgs1tm1Unc
involves: 129P2/OlaHsd 		abnormal small intestine crypts of Lieberkuhn morphology J:108679
decreased prostaglandin level J:108679
increased cellular sensitivity to gamma-irradiation J:108679
increased small intestinal crypt cell apoptosis J:108679
Ptgs1tm1Unc/Ptgs1tm1Unc
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood coagulation J:29511
abnormal blood flow velocity J:110043
abnormal circadian regulation of heart rate J:110043
abnormal circadian regulation of systemic arterial blood pressure J:110043
abnormal corpus luteum morphology J:50148
abnormal keratinocyte differentiation J:117986
abnormal kidney morphology J:29511
abnormal parturition J:50148
abnormal response of heart to induced stress J:103388
abnormal urine homeostasis J:110043
abnormal uterine environment J:29511
decreased inflammatory response J:29511
decreased physiological sensitivity to xenobiotic J:146321
decreased platelet aggregation J:29511
decreased prostaglandin level J:29511, J:50148, J:60668, J:103388, J:117986
decreased urine prostaglandin level J:110043
delayed parturition J:64073
normal digestive/alimentary phenotype J:29511, J:60668
enlarged spleen J:60668
hypotonia J:146321
increased circulating progesterone level J:50148
increased mean systemic arterial blood pressure J:110043
increased renal glomerular filtration rate J:110043
increased renal vascular resistance J:110043
increased susceptibility to endotoxin shock J:75611
increased susceptibility to induced colitis J:60668, J:158426
increased susceptibility to injury J:60668
increased susceptibility to xenobiotic induced morbidity/mortality J:60668
normal neoplasm J:158426
perinatal lethality, incomplete penetrance J:64073
Ptgs1tm1Unc/Ptgs1tm1Unc
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		delayed parturition J:64073
Ptgs1tm1Unc/Ptgs1tm1Unc
involves: 129P2/OlaHsd * C57BL/6 * DBA/1 		abnormal wound healing J:126734
Ptgs1tm1Unc/Ptgs1tm1Unc
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased prostaglandin level J:106147
Ptgs1tm1Unc/Ptgs1tm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		normal cardiovascular system phenotype J:109021
delayed parturition J:144423
normal homeostasis/metabolism phenotype J:54450
maternal effect J:144423
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory