Ptgs1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptgs1
prostaglandin-endoperoxide synthase 1
MGI:97797

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Ptgs1^tm1Unc/Ptgs1⁺ involves: 129P2/OlaHsd * C57BL/6J	decreased tumor incidence	J:64401
	intestine polyps	J:64401
	premature death	J:64401
Apc^Min/Apc⁺ Ptgs1^tm1Unc/Ptgs1^tm1Unc involves: 129P2/OlaHsd * C57BL/6J	decreased prostaglandin level	J:64401
	decreased tumor incidence	J:64401
	intestine polyps	J:64401
	normal mortality/aging	J:64401
Cnr1^tm1Zim/Cnr1^tm1Zim Ptgs1^tm1Unc/Ptgs1^tm1Unc involves: 129/Sv * 129P2/OlaHsd * C57BL/6J	early parturition	J:144423
	normal mortality/aging	J:144423
Hr^hr/Hr^hr Ptgs1^tm1Unc/Ptgs1⁺ involves: 129P2/OlaHsd * C57BL/6 * SKH1	decreased prostaglandin level	J:121635
	increased cell proliferation	J:121635
	normal neoplasm	J:121635
Nos3^tm1Plh/Nos3^tm1Plh Ptgs1^tm1Unc/Ptgs1^tm1Unc involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal blood vessel physiology	J:108540
	decreased physiological sensitivity to xenobiotic	J:108540
	decreased prostaglandin level	J:108540
	increased systemic arterial systolic blood pressure	J:108540
Ptgs1^tm1Fun/Ptgs1^tm1Fun Ptgs2^{tm2.1(Ptgs1)Fun}/Ptgs2^{tm2.1(Ptgs1)Fun} involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB	prenatal lethality	J:118171
Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2⁺ involves: 129P2/OlaHsd * C57BL/6J	delayed parturition	J:67208
Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2^tm1Unc involves: 129P2/OlaHsd * C57BL/6J	patent ductus arteriosus	J:67208
	postnatal lethality, complete penetrance	J:67208
Ptgs1^tm1Unc/Ptgs1^tm1Unc Oxt^tm1Ljm/Oxt^tm1Ljm involves: 129P2/OlaHsd * C57BL/6	decreased prostaglandin level	J:50148
	delayed parturition	J:50148
	lactation failure	J:50148
	normal reproductive system phenotype	J:50148
Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	neonatal lethality, complete penetrance	J:109548
	patent ductus arteriosus	J:109548
Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2⁺ involves: 129P2/OlaHsd * C57BL/6J	delayed parturition	J:67208
Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2^tm1Unc involves: 129P2/OlaHsd * C57BL/6 * CD-1	neonatal lethality, complete penetrance	J:64073
	patent ductus arteriosus	J:64073
Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2^tm1Unc involves: 129P2/OlaHsd * C57BL/6J	cyanosis	J:67208
	neonatal lethality, incomplete penetrance	J:67208
	patent ductus arteriosus	J:67208
	postnatal lethality, complete penetrance	J:67208
	respiratory distress	J:67208

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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