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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798
202 phenotypes from 14 alleles in 23 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
involves: 129S6/SvEvTac 		abnormal kidney cortex morphology J:148699
decreased renal glomerulus number J:148699
glomerulosclerosis J:148699
increased blood urea nitrogen level J:148699
kidney inflammation J:148699
Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
involves: 129S6/SvEvTac * C57BL/6 		abnormal kidney cortex morphology J:109548
abnormal renal glomerulus morphology J:109548
decreased prostaglandin level J:109548
glomerulosclerosis J:109548
pale kidney J:109548
reduced female fertility J:109548
small kidney J:109548
Ptgs2tm1.1Wls/Ptgs2tm1.1Wls
B6.129-Ptgs2tm1.1Wls 		normal cardiovascular system phenotype J:156331
impaired febrile response J:156331
increased susceptibility to endotoxin shock J:156331
increased urine prostaglandin level J:156331
normal renal/urinary system phenotype J:156331
normal reproductive system phenotype J:156331
Ptgs2tm1Fun/Ptgs2tm1Fun
involves: 129S6/SvEvTac * C57BL/6 		abnormal blood coagulation J:108957
abnormal platelet physiology J:108957
abnormal thrombolysis J:108957
decreased prostaglandin level J:109548
decreased susceptibility to induced thrombosis J:108957
decreased urine prostaglandin level J:108957
increased systemic arterial systolic blood pressure J:108957
Ptgs2tm1Gaf/Ptgs2tm1Gaf
A1cfTg(Myh6-cre/Esr1*)1Jmk/?
involves: 129/Sv * C57BL/6 * FVB/N 		decreased heart left ventricle muscle contractility J:148331
decreased heart rate J:148331
dilated heart left ventricle J:148331
impaired exercise endurance J:148331
increased myocardial fiber size J:148331
ventricular tachycardia J:148331
weight loss J:148331
Ptgs2tm1Hahe/Ptgs2tm1Hahe
involves: 129S4/SvJae 		no abnormal phenotype detected J:107615
Ptgs2tm1Jed/Ptgs2tm1Jed
B6;129S-Ptgs2tm1Jed/J 		abnormal stomach pH J:103642
decreased physiological sensitivity to xenobiotic J:103642
pulmonary interstitial fibrosis J:68669
Ptgs2tm1Jed/Ptgs2tm1Jed
involves: 129S7/SvEvBrd 		abnormal kidney collecting duct morphology J:29974
abnormal kidney cortex morphology J:29974
abnormal kidney corticomedullary boundary morphology J:29974
abnormal kidney development J:29974
abnormal kidney mesenchyme morphology J:29974
abnormal kidney morphology J:29974
abnormal renal glomerulus morphology J:29974
abnormal renal tubule morphology J:29974
absent corpus luteum J:29974
cardiac fibrosis J:29974
decreased ovulation rate J:29974
female infertility J:29974
normal hematopoietic system phenotype J:29974
normal immune system phenotype J:29974
increased blood urea nitrogen level J:29974
increased circulating creatinine level J:29974
kidney corticomedullary cyst J:29974
kidney failure J:29974
kidney medulla hypoplasia J:29974
neonatal lethality, incomplete penetrance J:29974
premature death J:29974
pyelonephritis J:29974
small ovary J:29974
Ptgs2tm1Jed/Ptgs2tm1Jed
involves: 129S7/SvEvBrd * C57BL/6 		abnormal decidualization J:43609
abnormal kidney cortex morphology J:104002
abnormal kidney development J:104002
abnormal primary polar body morphology J:43609
abnormal proximal convoluted tubule morphology J:104002
abnormal renal glomerulus morphology J:104002, J:109548, J:118171
normal behavior/neurological phenotype J:104002
normal cardiovascular system phenotype J:104002
cortical renal glomerulopathies J:118171
decreased kidney weight J:104002
decreased litter size J:118171
decreased prostaglandin level J:109548
decreased renal glomerular filtration rate J:104002
decreased superovulation rate J:43609, J:69034
decreased vascular permeability J:118171
dilated renal tubule J:104002
failure of embryo implantation J:43609
glomerulosclerosis J:104002, J:109548
normal growth/size/body region phenotype J:104002
normal homeostasis/metabolism phenotype J:104002
impaired fertilization J:43609
increased blood urea nitrogen level J:104002, J:118171
increased circulating creatinine level J:104002
increased heart weight J:104002
kidney cortex atrophy J:109548
kidney cortex cyst J:104002
kidney cyst J:104002
kidney degeneration J:104002
kidney failure J:104002
pale kidney J:109548
patent ductus arteriosus J:109548
peritoneal inflammation J:118171
premature death J:104002
proximal convoluted tubule brush border loss J:104002
reduced female fertility J:109548, J:118171
renal glomerulus cyst J:104002
renal glomerulus fibrosis J:104002
renal glomerulus hypertrophy J:104002
renal interstitial fibrosis J:104002
renal tubule atrophy J:104002
renal tubule hypertrophy J:104002
normal renal/urinary system phenotype J:104002
normal reproductive system phenotype J:69034
small kidney J:109548
Ptgs2tm1Jed/Ptgs2tm1Jed
involves: 129S7/SvEvBrd * CD-1 		abnormal response to infection J:120725
Ptgs2tm1Unc/Ptgs2+
B6.129P2-Ptgs2tm1Unc 		decreased cerebral infarct size J:67211
decreased prostaglandin level J:67211
Ptgs2tm1Unc/Ptgs2+
D1.129P2(B6J)-Ptgs2tm1Unc 		increased chemical nociceptive threshold J:64383
Ptgs2tm1Unc/Ptgs2+
D1.129P2-Ptgs2tm1Unc 		abnormal adipose tissue physiology J:102779
decreased total fat pad weight J:102779
increased body weight J:102779
increased circulating insulin level J:102779
increased circulating leptin level J:102779
increased prostaglandin level J:102779
increased susceptibility to diet-induced obesity J:102779
Ptgs2tm1Unc/Ptgs2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal osteoclast differentiation J:124756
decreased prostaglandin level J:124756
Ptgs2tm1Unc/Ptgs2+
involves: 129P2/OlaHsd * C57BL/6J 		impaired febrile response J:54450
increased systemic arterial systolic blood pressure J:155373
Ptgs2tm1Unc/Ptgs2tm1Unc
B6.129P2-Ptgs2tm1Unc 		abnormal choriocapillaris morphology J:281382
abnormal class switch recombination J:140698
abnormal drinking behavior J:125586
abnormal memory B cell differentiation J:140698
abnormal nociception after inflammation J:110716
abnormal response to CNS ischemic injury J:67211
abnormal response to infection J:140698
abnormal response/metabolism to endogenous compounds J:125586
allodynia J:110716
decreased cerebral infarct size J:67211
decreased IgG1 level J:140698
decreased IgG2a level J:140698
decreased IgG3 level J:140698
decreased prostaglandin level J:67211
decreased susceptibility to induced arthritis J:110716
decreased susceptibility to neuronal excitotoxicity J:67211
increased IgM level J:140698
increased thermal nociceptive threshold J:110716
Ptgs2tm1Unc/Ptgs2tm1Unc
B6;129P2-Ptgs2tm1Unc/Tac 		abnormal bone healing J:112346
abnormal endochondral bone ossification J:112346
abnormal inhibitory postsynaptic currents J:141610
abnormal response to injury J:107751
decreased prostaglandin level J:141610
impaired skeletal muscle regeneration J:107751
increased susceptibility to neuronal excitotoxicity J:141610
increased susceptibility to pharmacologically induced seizures J:141610
increased susceptibility to xenobiotic induced morbidity/mortality J:141610
renal glomerulus hypertrophy J:156331
tonic-clonic seizures J:141610
Ptgs2tm1Unc/Ptgs2tm1Unc
D1.129P2(B6J)-Ptgs2tm1Unc 		abnormal kidney mesenchyme morphology J:102777
abnormal kidney morphology J:64383
abnormal renal glomerulus morphology J:102777
normal behavior/neurological phenotype J:64383
decreased aggression J:64383
decreased hematocrit J:102777
decreased kidney weight J:102777
female infertility J:64383
granular kidney J:102777
increased blood urea nitrogen level J:102777
increased circulating creatinine level J:102777
normal mortality/aging J:64383
pale kidney J:102777
postnatal lethality J:102777
renal glomerulus cyst J:102777
renal glomerulus hypertrophy J:102777
renal interstitial fibrosis J:102777
small kidney J:102777
Ptgs2tm1Unc/Ptgs2tm1Unc
D1.129P2-Ptgs2tm1Unc 		decreased prostaglandin level J:102779
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal osteoclast differentiation J:124756
decreased platelet calcium level J:124756
decreased prostaglandin level J:124756
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd 		normal digestive/alimentary phenotype J:108679
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd * C57BL/6 		abnormal colon morphology J:60668
abnormal enzyme/coenzyme level J:108054
abnormal keratinocyte differentiation J:117986
abnormal kidney cortex morphology J:104002
abnormal kidney development J:104002
abnormal proximal convoluted tubule morphology J:104002
abnormal renal glomerulus morphology J:104002
abnormal response of heart to induced stress J:103388
anemia J:60668
normal behavior/neurological phenotype J:104002
normal cardiovascular system phenotype J:104002
decreased hematocrit J:60668
decreased incidence of tumors by chemical induction J:158426
decreased kidney weight J:104002
decreased lactate dehydrogenase level J:108054
decreased prostaglandin level J:60668, J:117986
decreased renal glomerular filtration rate J:104002
decreased susceptibility to endotoxin shock J:75611
decreased susceptibility to induced pancreatitis J:108054
decreased susceptibility to injury J:108054
dilated renal tubule J:104002
enlarged spleen J:60668
glomerulosclerosis J:104002
normal growth/size/body region phenotype J:104002
normal homeostasis/metabolism phenotype J:104002
increased blood urea nitrogen level J:104002
increased circulating creatinine level J:104002
increased heart weight J:104002
increased incidence of induced tumors J:158426
increased leukocyte cell number J:60668
increased susceptibility to induced colitis J:60668, J:158426
increased susceptibility to xenobiotic induced morbidity/mortality J:60668, J:158426
increased tumor necrosis factor secretion J:108054
kidney cortex cyst J:104002
kidney cyst J:104002
kidney degeneration J:104002
kidney failure J:104002
normal muscle phenotype J:146321
pancreas necrosis J:108054
peritoneal inflammation J:60668
premature death J:104002
proximal convoluted tubule brush border loss J:104002
renal glomerulus cyst J:104002
renal glomerulus fibrosis J:104002
renal glomerulus hypertrophy J:104002
renal interstitial fibrosis J:104002
renal tubule atrophy J:104002
renal tubule hypertrophy J:104002
normal renal/urinary system phenotype J:104002
weight loss J:60668
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd * C57BL/6 * DBA/1 		abnormal wound healing J:126734
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal corpus luteum morphology J:55145
abnormal cumulus expansion J:55145
abnormal induced retina neovascularization J:109021
abnormal intestinal mucosa morphology J:29510
abnormal kidney capsule morphology J:29510
abnormal kidney development J:29510
abnormal kidney morphology J:29510
abnormal kidney papilla morphology J:29510
abnormal lipid homeostasis J:121680
abnormal liver morphology J:67208
abnormal macrophage physiology J:29510
abnormal mesenteric lymph node morphology J:29510
abnormal nephrogenic zone morphology J:29510
abnormal reproductive system physiology J:29510
abnormal thrombosis J:109021
decreased nephron number J:29510
decreased prostaglandin level J:55145, J:109021
decreased renal glomerulus number J:29510
decreased superovulation rate J:55145
decreased survivor rate J:67208
dilated renal tubule J:29510
failure of superovulation J:55145
female infertility J:55145
glomerulosclerosis J:29510
normal homeostasis/metabolism phenotype J:55145
normal immune system phenotype J:29510
impaired febrile response J:54450
impaired granulosa cell differentiation J:55145
increased circulating follicle stimulating hormone level J:55145
increased circulating luteinizing hormone level J:55145
increased systemic arterial blood pressure J:155373
increased systemic arterial diastolic blood pressure J:155373
increased systemic arterial systolic blood pressure J:155373
intestinal edema J:29510
kidney cortex atrophy J:29510
neonatal lethality, incomplete penetrance J:67208
nephrocalcinosis J:29510
pale kidney J:29510, J:55145
patent ductus arteriosus J:67208
peritoneal inflammation J:29510
postnatal lethality, incomplete penetrance J:67208
premature death J:29510
renal cast J:29510
renal glomerulus hypertrophy J:29510
renal interstitial fibrosis J:29510
renal tubule atrophy J:29510
small kidney J:29510
spleen hyperplasia J:29510
tubulointerstitial nephritis J:29510
Ptgs2tm1Unc/Ptgs2tm2.1Hahe
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		increased susceptibility to induced colitis J:158426
increased susceptibility to xenobiotic induced morbidity/mortality J:158426
normal neoplasm J:158426
Ptgs2tm1Wlf/Ptgs2tm1Wlf
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal chemical nociception J:146193
abnormal nociception after inflammation J:146193
normal homeostasis/metabolism phenotype J:146193
Ptgs2tm3Fun/Ptgs2tm3Fun
involves: 129S6/SvEvTac * C57BL/6J 		abnormal renal glomerulus morphology J:148699
abnormal renal tubule morphology J:148699
abnormal urine homeostasis J:148699
normal cardiovascular system phenotype J:148699
increased blood urea nitrogen level J:148699
increased platelet aggregation J:148699
increased susceptibility to induced thrombosis J:148699
normal renal/urinary system phenotype J:148699
Tg(K5-Ptgs2)19Kmd/0
involves: NMRI 		abnormal coat appearance J:70039
abnormal dermal layer morphology J:70039
abnormal hair follicle development J:70039
abnormal hair follicle orientation J:70039
abnormal nail morphology J:70039
alopecia J:70039
coarse hair J:70039
decreased hair follicle number J:70039
epidermal hyperplasia J:70039
greasy coat J:70039
hyperkeratosis J:70039
increased incidence of tumors by chemical induction J:79071
increased prostaglandin level J:70039
increased sebaceous gland adenoma incidence J:79071
increased skin papilloma incidence J:79071
increased squamous cell carcinoma incidence J:79071
long toenails J:70039
sebaceous gland hyperplasia J:70039
sparse hair J:70039
thin skin J:70039
Tg(K5-Ptgs2)667Kmd/0
involves: NMRI 		abnormal coat appearance J:70039
abnormal coat/ hair morphology J:70039
abnormal dermal layer morphology J:70039
abnormal hair follicle development J:70039
abnormal hair follicle orientation J:70039
abnormal nail morphology J:70039
alopecia J:70039
coarse hair J:70039
decreased hair follicle number J:70039
epidermal hyperplasia J:70039
hyperkeratosis J:70039
increased incidence of tumors by chemical induction J:79071
increased prostaglandin level J:70039
increased sebaceous gland adenoma incidence J:79071
increased skin papilloma incidence J:79071
increased squamous cell carcinoma incidence J:79071
long toenails J:70039
premature death J:79071
sebaceous gland hyperplasia J:70039
sparse hair J:70039
thin skin J:70039
Tg(K5-Ptgs2)675Kmd/0
involves: NMRI 		abnormal coat appearance J:70039
abnormal coat/ hair morphology J:70039
abnormal dermal layer morphology J:70039
abnormal hair follicle development J:70039
abnormal hair follicle orientation J:70039
abnormal nail morphology J:70039
alopecia J:70039
coarse hair J:70039
decreased hair follicle number J:70039
epidermal hyperplasia J:70039
greasy coat J:70039
hyperkeratosis J:70039
increased prostaglandin level J:70039
long toenails J:70039
premature death J:70039
sebaceous gland hyperplasia J:70039
sparse hair J:70039
thin skin J:70039
Tg(K5-Ptgs2)675Kmd/Tg(K5-Ptgs2)675Kmd
involves: NMRI 		abnormal hair cycle J:85979
abnormal hair follicle morphology J:85979
alopecia J:85979
sebaceous gland hyperplasia J:85979
sparse hair J:85979
Tg(Nphs1-Ptgs2)14Rhrs/0
involves: C57BL/6 * DBA/2 		abnormal glomerular mesangium morphology J:148158, J:179350
abnormal podocyte morphology J:179350
albuminuria J:148158, J:179350
increased renal glomerulus basement membrane thickness J:179350
increased susceptibility to injury J:148158
podocyte foot process effacement J:148158, J:179350
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory