Ptgs2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798

36 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Ptgs2^tm1Unc/Ptgs2^tm1Unc involves: 129P2/OlaHsd * C57BL/6J	decreased prostaglandin level	J:64401
	decreased tumor incidence	J:64401
	intestine polyps	J:64401
	premature death	J:64401
Apc^tm1Mmt/Apc⁺ Ptgs2^tm1Jed/Ptgs2⁺ involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	abnormal intestine morphology	J:36816
	colon polyps	J:36816
Apc^tm1Mmt/Apc⁺ Ptgs2^tm1Jed/Ptgs2^tm1Jed involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	abnormal intestine morphology	J:36816
Gins4^tm1Ntak/Gins4⁺ Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0 Tg(Krt19-Wnt1)2Maos/0 involves: 129P2/OlaHsd * C3H * C57BL/6	decreased tumor growth/size	J:209708
Hmga1^tm1Mina/Hmga1^tm1Mina Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0 Tg(Krt19-Wnt1)2Maos/0 involves: C3H * C57BL/6 * CBA	increased stomach tumor incidence	J:153058
Hr^hr/Hr^hr Ptgs2^tm1Unc/Ptgs2⁺ involves: 129P2/OlaHsd * C57BL/6 * SKH1	decreased incidence of tumors by UV induction	J:121635
	decreased prostaglandin level	J:121635
	increased cell proliferation	J:121635
Hr^hr/Hr^hr Ptgs2^tm1Unc/Ptgs2^tm1Unc involves: 129P2/OlaHsd * C57BL/6 * SKH1	premature death	J:121635
Hr^hr/Hr^hr Tg(KRT14-Ptgs2)1Sumf/0 involves: C57BL/6 * DBA/2 * FVB/N * SKH1	decreased cell proliferation	J:121635
	increased incidence of tumors by UV-induction	J:121635
	increased prostaglandin level	J:121635
Ptgs1^tm1Fun/Ptgs1^tm1Fun Ptgs2^{tm2.1(Ptgs1)Fun}/Ptgs2^{tm2.1(Ptgs1)Fun} involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB	prenatal lethality	J:118171
Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2⁺ involves: 129P2/OlaHsd * C57BL/6J	delayed parturition	J:67208
Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2^tm1Unc involves: 129P2/OlaHsd * C57BL/6J	patent ductus arteriosus	J:67208
	postnatal lethality, complete penetrance	J:67208
Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	neonatal lethality, complete penetrance	J:109548
	patent ductus arteriosus	J:109548
Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2⁺ involves: 129P2/OlaHsd * C57BL/6J	delayed parturition	J:67208
Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2^tm1Unc involves: 129P2/OlaHsd * C57BL/6 * CD-1	neonatal lethality, complete penetrance	J:64073
	patent ductus arteriosus	J:64073
Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2^tm1Unc involves: 129P2/OlaHsd * C57BL/6J	cyanosis	J:67208
	neonatal lethality, incomplete penetrance	J:67208
	patent ductus arteriosus	J:67208
	postnatal lethality, complete penetrance	J:67208
	respiratory distress	J:67208
Ptgs2^tm1Jed/Ptgs2⁺ Stk11^tm1Tpm/Stk11⁺ involves: 129S7/SvEvBrd * C57BL/6 * CD-1	gastric polyps	J:93361
	intestine polyps	J:93361
Ptgs2^tm1Jed/Ptgs2^tm1Jed Stk11^tm1Tpm/Stk11⁺ involves: 129S7/SvEvBrd * C57BL/6 * CD-1	decreased tumor incidence	J:93361
	gastric polyps	J:93361
	intestine polyps	J:93361
Ptgs2^{tm2(Ptgs1)Fun}/Ptgs2^{tm2(Ptgs1)Fun} involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal macrophage physiology	J:118171
	preweaning lethality, incomplete penetrance	J:118171
Ptgs2^{tm2.1(Ptgs1)Fun}/Ptgs2^{tm2.1(Ptgs1)Fun} involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB	abnormal fertility/fecundity	J:118171
	abnormal macrophage physiology	J:118171
	abnormal renal glomerulus morphology	J:118171
	decreased litter size	J:118171
	decreased urine prostaglandin level	J:118171
	decreased vascular permeability	J:118171
	increased blood urea nitrogen level	J:118171
	kidney inflammation	J:118171
	peritoneal inflammation	J:118171
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0 involves: C3H * C57BL/6	gastric metaplasia	J:116782
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0 Tg(Krt19-Wnt1)2Maos/0 involves: C3H * C57BL/6	abnormal stomach glandular epithelium morphology	J:116782
	decreased tumor-free survival time	J:116782
	gastric metaplasia	J:116782
	increased gastric adenocarcinoma incidence	J:116782
	increased stomach tumor incidence	J:116782, J:153058

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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