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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pthlh
parathyroid hormone-like peptide
MGI:97800
114 phenotypes from 7 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pthlhtm1a(KOMP)Wtsi/Pthlh+
C57BL/6N-Pthlhtm1a(KOMP)Wtsi/Wtsi 		abnormal cranium morphology J:211773
abnormal head morphology J:211773
increased blood urea nitrogen level J:211773
Pthlhtm1a(KOMP)Wtsi/Pthlhtm1a(KOMP)Wtsi
C57BL/6N-Pthlhtm1a(KOMP)Wtsi/Wtsi 		abnormal brain vasculature morphology J:239583
abnormal cervical rib J:239583
abnormal ductus venosus valve morphology J:239583
abnormal forebrain morphology J:239583
abnormal inferior vena cava morphology J:239583
dilated liver sinusoidal space J:239583
embryo tumor J:239583
no abnormal phenotype detected J:239583
preweaning lethality, complete penetrance J:211773
Pthlhtm1Ack/Pthlhtm1.1Ack
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB/N 		abnormal long bone epiphyseal plate morphology J:69396
abnormal long bone epiphyseal plate proliferative zone J:69396
distended abdomen J:69396
domed cranium J:69396
neonatal lethality, complete penetrance J:69396
premature endochondral bone ossification J:69396
protruding tongue J:69396
respiratory failure J:69396
short mandible J:69396
small thoracic cavity J:69396
Pthlhtm1Ack/Pthlhtm1Ack
Tg(Col1a1-cre)1Ack/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal bone ossification J:100918
abnormal osteoblast morphology J:100918
abnormal osteoclast morphology J:100918
abnormal trabecular bone morphology J:100918
decreased bone mineral density J:100918
decreased osteoblast cell number J:100918
decreased osteoclast cell number J:100918
Pthlhtm1Ack/Pthlhtm1Hmk
Tg(LGB-cre)74Acl/0
involves: 129 * C57BL/6 * CBA 		abnormal bone ossification J:86536
abnormal circulating hormone level J:86536
abnormal osteoclast morphology J:86536
abnormal urine homeostasis J:86536
abnormal vitamin D level J:86536
increased bone mass J:86536
normal reproductive system phenotype J:86536
Pthlhtm1Ack/Pthlhtm1Hmk
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129 * BALB/c * FVB/N 		abnormal long bone epiphyseal plate morphology J:69396
abnormal long bone epiphyseal plate proliferative zone J:69396
disorganized long bone epiphyseal plate J:69396
distended abdomen J:69396
domed cranium J:69396
neonatal lethality, complete penetrance J:69396
premature endochondral bone ossification J:69396
protruding tongue J:69396
respiratory failure J:69396
short mandible J:69396
small thoracic cavity J:69396
Pthlhtm1Broa/Pthlhtm1Broa
involves: 129S1/Sv * C57BL/6J * CD-1 		abnormal long bone epiphyseal plate proliferative zone J:128121
chondrodystrophy J:128121
short ribs J:128121
Pthlhtm1Fbe/Pthlhtm1Fbe
involves: 129S1/Sv * 129X1/SvJ 		abnormal axial skeleton morphology J:109505
abnormal calcium ion homeostasis J:79622
abnormal circulating calcium level J:79622
abnormal long bone epiphyseal plate morphology J:109505
abnormal long bone hypertrophic chondrocyte zone J:109505
decreased long bone epiphyseal plate size J:109505
domed cranium J:109505
neonatal lethality, complete penetrance J:109505
short femur J:109505
short humerus J:109505
short limbs J:109505
short radius J:109505
short ribs J:109505
short ulna J:109505
Pthlhtm1Fbe/Pthlhtm1Fbe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal clavicle morphology J:112521
abnormal mandible morphology J:112521
abnormal osteoblast morphology J:112521
abnormal trabecular bone morphology J:112521
domed cranium J:112521
protruding tongue J:112521
short mandible J:112521
short snout J:112521
Pthlhtm1Fbe/Pthlhtm1Fbe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		failure of tooth eruption J:109342
Pthlhtm1Hmk/Pthlh+
involves: 129S2/SvPas 		abnormal bone ossification J:100918
abnormal osteoblast differentiation J:100918
abnormal osteoclast morphology J:100918
abnormal trabecular bone morphology J:100918
decreased osteoblast cell number J:100918
Pthlhtm1Hmk/Pthlh+
involves: 129S2/SvPas * C57BL/6 		decreased long bone epiphyseal plate size J:99641
Pthlhtm1Hmk/Pthlhtm1Hmk
either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) 		abnormal axial skeleton morphology J:16911
abnormal bone mineralization J:16911
abnormal bone trabecula morphology J:16911
abnormal cartilage development J:16911
abnormal long bone epiphyseal plate morphology J:16911
abnormal long bone epiphyseal plate proliferative zone J:16911
abnormal long bone metaphysis morphology J:16911
abnormal long bone morphology J:16911
abnormal rib morphology J:16911
abnormal skeleton development J:16911
abnormal thoracic cage shape J:16911
abnormal vertebral body morphology J:16911
chondrodystrophy J:16911
cyanosis J:16911
decreased length of long bones J:16911
domed cranium J:16911
increased diameter of long bones J:16911
perinatal lethality, complete penetrance J:16911
premature endochondral bone ossification J:16911
protruding tongue J:16911
respiratory failure J:16911
short limbs J:16911
short mandible J:16911
short ribs J:16911
short snout J:16911
short sternum J:16911
splayed ribs J:16911
Pthlhtm1Hmk/Pthlhtm1Hmk
involves: 129S2/SvPas 		abnormal bone mineralization J:50144
abnormal sternum ossification J:50144
Pthlhtm1Hmk/Pthlhtm1Hmk
involves: 129S2/SvPas * C57BL/6 		abnormal long bone morphology J:77639
abnormal lung development J:90274
abnormal lung interstitium morphology J:90274
abnormal lung morphology J:90274
abnormal lung saccule morphology J:90274
abnormal mesenchymal cell differentiation involved in lung development J:90274
abnormal pulmonary alveolus epithelium morphology J:90274
abnormal type II pneumocyte morphology J:90274
absent type I pneumocytes J:90274
atelectasis J:90274
decreased alveolar lamellar body number J:90274
decreased length of long bones J:77639
decreased long bone epiphyseal plate size J:77639
decreased surfactant secretion J:90274
domed cranium J:77639
perinatal lethality, complete penetrance J:90274
premature bone ossification J:77639
respiratory failure J:90274
short mandible J:77639
small lung J:90274
small lung saccule J:90274
small thoracic cavity J:90274
thick lung-associated mesenchyme J:90274
Pthlhtm1Hmk/Pthlhtm1Hmk
involves: 129S2/SvPas * C57BL/6J 		abnormal bone mineralization J:76407
abnormal bone structure J:76407
abnormal cartilage development J:76407
abnormal long bone epiphyseal plate proliferative zone J:76407
abnormal long bone hypertrophic chondrocyte zone J:76407
abnormal osteoclast morphology J:76407
abnormal trabecular bone morphology J:76407
decreased length of long bones J:76407
decreased osteoclast cell number J:76407
disproportionate dwarf J:76407
enlarged parathyroid gland J:76407
increased chondrocyte apoptosis J:76407
increased compact bone thickness J:76407
increased osteoblast apoptosis J:76407
increased osteoblast cell number J:76407
increased osteocyte apoptosis J:76407
increased width of hypertrophic chondrocyte zone J:76407
perinatal lethality, complete penetrance J:76407
short limbs J:76407
short tibia J:76407
Pthlhtm2Ack/Pthlhtm2Ack
involves: 129S2/SvPas * C57BL/6 		abnormal autophagy J:142669
abnormal blood vessel morphology J:142669
abnormal gait J:142669
abnormal long bone epiphyseal plate proliferative zone J:142669
abnormal trabecular bone morphology J:142669
cachexia J:142669
decreased body size J:142669
decreased bone mineral density J:142669
decreased brain size J:142669
decreased cell proliferation J:142669
decreased chondrocyte number J:142669
decreased chondrocyte proliferation J:142669
decreased circulating glucose level J:142669
decreased long bone epiphyseal plate size J:142669
decreased osteoblast cell number J:142669
decreased osteoclast cell number J:142669
decreased total body fat amount J:142669
normal growth/size/body region phenotype J:142669
hyperkeratosis J:142669
increased apoptosis J:142669
kyphosis J:142669
osteoporosis J:142669
postnatal growth retardation J:142669
postnatal lethality, complete penetrance J:142669
premature aging J:142669
normal skeleton phenotype J:142669
thin epidermis J:142669
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory