Ptma Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptma
prothymosin alpha
MGI:97803

32 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptma^{tm1.1(KOMP)Vlcg}/Ptma⁺ C57BL/6N-Ptma^{tm1.1(KOMP)Vlcg}/Ucd	cornea opacity	J:211773
	persistence of hyaloid vascular system	J:211773
Ptma^{tm1.1(KOMP)Vlcg}/Ptma^{tm1.1(KOMP)Vlcg} C57BL/6N-Ptma^{tm1.1(KOMP)Vlcg}/Ucd	preweaning lethality, complete penetrance	J:211773
Ptma^tm1.1Got/Ptma⁺ involves: C57BL/6J * C57BL/6NTac	abnormal excitatory postsynaptic potential	J:240549
	abnormal hippocampus neuron morphology	J:240549
	abnormal learning/memory/conditioning	J:240549
	abnormal neuron differentiation	J:240549
	abnormal neuron proliferation	J:240549
	abnormal passive avoidance behavior	J:240549
	normal behavior/neurological phenotype	J:240549
	decreased body temperature	J:240549
	decreased body weight	J:240549
	decreased locomotor activity	J:240549
	impaired cued conditioning behavior	J:240549
	impaired spatial learning	J:240549
	increased anxiety-related response	J:240549
	reduced long-term potentiation	J:240549
Ptma^tm1.1Got/Ptma^tm1.1Got involves: C57BL/6J * C57BL/6NTac	embryonic lethality, complete penetrance	J:240549
Tg(Actb-Ptma)T12Clwu/0 involves: FVB/N	emphysema	J:270215
Tg(Actb-Ptma)T12Clwu/0 involves: FVB/N	kidney cyst	J:128557
Tg(Actb-Ptma)T12Clwu/Tg(Actb-Ptma)T12Clwu involves: FVB/N	abnormal eating behavior	J:128557
	decreased birth weight	J:128557
	emphysema	J:128557, J:270215
	increased blood urea nitrogen level	J:128557
	increased kidney weight	J:128557
	increased liver weight	J:128557
	kidney epithelium hyperplasia	J:128557
	polycystic kidney	J:128557
	postnatal growth retardation	J:128557
	postnatal lethality, complete penetrance	J:128557, J:270215
	pulmonary fibrosis	J:128557
	renal fibrosis	J:128557
	slow postnatal weight gain	J:128557

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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