Ptpn1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptpn1
protein tyrosine phosphatase, non-receptor type 1
MGI:97805

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Irs2^tm1Mfw/Irs2^tm1Mfw Ptpn1^tm1Bbk/Ptpn1^tm1Bbk involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal pancreatic beta cell morphology	J:87249
	decreased body weight	J:87249
	hyperglycemia	J:87249
	impaired glucose tolerance	J:87249
	increased insulin sensitivity	J:87249
	pancreatic islet hyperplasia	J:87249
	premature death	J:87249
Pten^tm1Hwu/Pten^tm1Hwu Ptpn1^tm1Bpk/Ptpn1^tm1Bpk Tg(Pbsn-cre)4Prb/0 involves: 129S4/SvJae * C57BL/6 * DBA/2	increased prostate gland adenocarcinoma incidence	J:231906
	increased prostate intraepithelial neoplasia incidence	J:231906
Ptpn1^tm2Bbk/Ptpn1^tm2Bbk Ptpn2^tm1.1Ttig/Ptpn2^tm1.1Ttig Tg(Nes-cre)1Kln/0 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL	abnormal eating behavior	J:179621
	abnormal glucose homeostasis	J:179621
	abnormal respiratory quotient	J:179621
	decreased body length	J:179621
	decreased body weight	J:179621
	decreased circulating glucose level	J:179621
	decreased circulating leptin level	J:179621
	decreased susceptibility to diet-induced obesity	J:179621
	increased energy expenditure	J:179621
	increased insulin sensitivity	J:179621
	increased oxygen consumption	J:179621
	increased response to leptin	J:179621

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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