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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptpn2
protein tyrosine phosphatase, non-receptor type 2
MGI:97806
96 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ptpn2tm1.1Kry/Ptpn2tm1.1Kry
Tg(Col1a1-cre)1Kry/0
involves: 129 * C57BL/6J * FVB 		abnormal osteoclast differentiation J:183709
abnormal osteoclast physiology J:183709
normal homeostasis/metabolism phenotype J:183709
increased bone resorption J:183709
increased carbon dioxide production J:183709
increased circulating osteocalcin level J:183709
increased energy expenditure J:183709
increased insulin sensitivity J:183709
increased oxygen consumption J:183709
normal skeleton phenotype J:183709
Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * C57BL/6J * SJL 		abnormal eating behavior J:179621
abnormal glucose homeostasis J:179621
decreased body length J:179621
decreased body weight J:179621
decreased bone marrow cell number J:179621
decreased bone mineral content J:179621
decreased bone mineral density J:179621
decreased bone trabecula number J:179621
decreased circulating glucose level J:179621
decreased circulating growth hormone level J:179621
decreased circulating insulin level J:179621
decreased circulating insulin-like growth factor I level J:179621
decreased circulating leptin level J:179621
decreased locomotor activity J:179621
decreased susceptibility to diet-induced obesity J:179621
decreased trabecular bone volume J:179621
increased adiponectin level J:179621
increased energy expenditure J:179621
increased insulin sensitivity J:179621
increased oxygen consumption J:179621
increased response to leptin J:179621
increased total body fat amount J:179621
Ptpn2tm1a(EUCOMM)Wtsi/Ptpn2+
C57BL/6N-Ptpn2tm1a(EUCOMM)Wtsi/Wtsi 		increased hemoglobin content J:175295
increased mean corpuscular hemoglobin J:175295
Ptpn2tm1Mtr/Ptpn2tm1Mtr
B6.129S4(C)-Ptpn2tm1Mtr 		abnormal bone marrow cell number J:186843
abnormal lymph node morphology J:186843
decreased B cell number J:186843
decreased B-1 B cell number J:186843
decreased body size J:186843
decreased bone marrow cell number J:186843
decreased bone mineral content J:186843
decreased CD4-positive, alpha-beta T cell number J:186843
decreased double-positive T cell number J:186843
decreased erythrocyte cell number J:186843
decreased erythroid progenitor cell number J:186843
decreased follicular B cell number J:186843
decreased immature B cell number J:186843
decreased lean body mass J:186843
decreased marginal zone B cell number J:186843
decreased mature B cell number J:186843
decreased single-positive T cell number J:186843
decreased T cell number J:186843
decreased thymocyte number J:186843
decreased total body fat amount J:186843
normal hematopoietic system phenotype J:186843
increased bone mineral density J:186843
premature death J:186843
normal skeleton phenotype J:186843
thymus atrophy J:186843
Ptpn2tm1Mtr/Ptpn2tm1Mtr
C.129S4-Ptpn2tm1Mtr 		abnormal bone marrow cell number J:186843
abnormal bone structure J:186843
abnormal bone trabecula morphology J:186843
abnormal long bone epiphyseal ossification zone morphology J:186843
abnormal long bone morphology J:186843
abnormal lymph node morphology J:186843
abnormal negative T cell selection J:186843
abnormal ossification involved in bone maturation J:186843
abnormal pilomotor reflex J:186843
abnormal positive T cell selection J:186843
abnormal skeleton morphology J:186843
abnormal T cell differentiation J:186843
abnormal T cell subpopulation ratio J:186843
decreased B cell number J:186843
decreased B-1 B cell number J:186843
decreased body size J:186843
decreased bone marrow cell number J:186843
decreased bone mineral content J:186843
decreased CD4-positive, alpha-beta T cell number J:186843
decreased diameter of femur J:186843
decreased double-positive T cell number J:186843
decreased erythrocyte cell number J:186843
decreased erythroid progenitor cell number J:186843
decreased follicular B cell number J:186843
decreased immature B cell number J:186843
decreased lean body mass J:186843
decreased locomotor activity J:186843
decreased marginal zone B cell number J:186843
decreased mature B cell number J:186843
decreased single-positive T cell number J:186843
decreased T cell number J:186843
decreased thymocyte number J:186843
decreased total body fat amount J:186843
diarrhea J:186843
enlarged spleen J:186843
hunched posture J:186843
increased bone mineral density J:186843
increased bone trabecula number J:186843
increased splenocyte number J:186843
increased trabecular bone volume J:186843
postnatal lethality, incomplete penetrance J:186843
premature death J:186843
short femur J:186843
thymus atrophy J:186843
Ptpn2tm1Mtr/Ptpn2tm1Mtr
involves: 129S4/SvJae * BALB/c 		abnormal B cell number J:42595
abnormal bone marrow cell morphology/development J:42595
abnormal erythropoiesis J:42595
abnormal inflammatory response J:90541
abnormal spleen morphology J:42595
abnormal thymus involution J:42595
anemia J:42595
decreased B cell number J:42595
decreased double-positive T cell number J:42595
decreased hematocrit J:42595
decreased locomotor activity J:42595
diarrhea J:42595
enlarged lymph nodes J:42595
enlarged spleen J:42595
hunched posture J:42595
increased B cell number J:42595
increased inflammatory response J:90541
increased interferon-gamma secretion J:90541
increased interleukin-12 secretion J:90541
increased macrophage cell number J:42595
increased mature B cell number J:42595
increased pre-B cell number J:42595
increased spleen red pulp amount J:42595
increased tumor necrosis factor secretion J:90541
lymph node hyperplasia J:42595
narrow eye opening J:42595
postnatal growth retardation J:42595
premature death J:42595
spleen hyperplasia J:42595
Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig
B6.Cg-Ptpn2tm2.1Ttig 		abnormal bone marrow cell number J:186843
abnormal negative T cell selection J:186843
abnormal positive T cell selection J:186843
abnormal skeleton morphology J:186843
abnormal T cell differentiation J:186843
abnormal T cell subpopulation ratio J:186843
decreased B cell number J:186843
decreased B-1 B cell number J:186843
decreased body size J:186843
decreased bone marrow cell number J:186843
decreased bone mineral content J:186843
decreased CD4-positive, alpha-beta T cell number J:186843
decreased double-positive T cell number J:186843
decreased erythrocyte cell number J:186843
decreased erythroid progenitor cell number J:186843
decreased follicular B cell number J:186843
decreased immature B cell number J:186843
decreased lean body mass J:186843
decreased long bone epiphyseal plate size J:186843
decreased marginal zone B cell number J:186843
decreased mature B cell number J:186843
decreased single-positive T cell number J:186843
decreased thymocyte number J:186843
decreased total body fat amount J:186843
enlarged lymph nodes J:186843
normal hematopoietic system phenotype J:186843
increased bone mineral density J:186843
premature death J:186843
normal skeleton phenotype J:186843
thymus atrophy J:186843
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory