Ptprc Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptprc
protein tyrosine phosphatase receptor type C
MGI:97810

45 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Ptprc^tm1(cre)Medv/? B6.Cg-Ptprc^tm1(cre)Medv Abcc6^{tm1c(EUCOMM)Wtsi}	normal integument phenotype	J:252837
Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^ltng involves: 129S7/SvEvBrd * C57BL/6	thymus hypoplasia	J:158876
Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^tm1Mak involves: 129S7/SvEvBrd * C57BL/6	abnormal T cell differentiation	J:158876
	thymus hypoplasia	J:158876
Dhx9^{Tn(pb-Act-RFP)1.071225026-HRAZhu}/Dhx9⁺ Igs12^tm1Zhu/Igs12^tm1Zhu Ptprc^a/Ptprc^b Tg(Lck-cre)#Zhu/0 involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J	abnormal T cell differentiation	J:207361
Ncr1^m1J/Ncr1^m1J Pepc^b/Pepc^b Ptprc^a/Ptprc^a B6.SJL-Ptprc^a Pepc^b/BoyJ	abnormal interferon level	J:257226
	abnormal NK cell physiology	J:257226
	abnormal susceptibility to infection induced morbidity/mortality	J:257226
	decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality	J:257226
	increased susceptibility to Herpesvirales infection induced morbidity/mortality	J:257226
Ptpn22^tm2Achn/Ptpn22^tm2Achn Ptprc^tm1Weis/Ptprc^tm1Weis B6.Cg-Ptprc^tm1Weis Ptpn22^tm2Achn	abnormal B cell activation	J:147129
	abnormal double-positive T cell morphology	J:147129
	abnormal follicular B cell physiology	J:147129
	abnormal lymphocyte cell number	J:147129
	abnormal T cell activation	J:147129
	abnormal T cell subpopulation ratio	J:147129
	abnormal thymocyte activation	J:147129
	decreased body weight	J:147129
	decreased follicular B cell number	J:147129
	enlarged lymph nodes	J:147129
	glomerulonephritis	J:147129
	glomerulosclerosis	J:147129
	increased autoantibody level	J:147129
	increased memory T cell number	J:147129
	increased plasma cell number	J:147129
	increased transitional stage B cell number	J:147129
	increased urine protein level	J:147129
	liver inflammation	J:147129
	lung inflammation	J:147129
	pale kidney	J:147129
	premature death	J:147129
Ptprc^ltng/Ptprc^tm1Mak Tg(TcraTcrb)425Cbn/0 involves: 129/Sv * BALB/c * C57BL/6	decreased CD4-positive, alpha-beta T cell number	J:158876
	thymus hypoplasia	J:158876
Ptprc^tm1Holm/Ptprc^tm1Holm Tg(LckF505)2964Rmp/? involves: 129/Sv C57BL/6 * DBA/2	increased T cell derived lymphoma incidence	J:64671
	thymus hyperplasia	J:64671
Ptprc^tm1Holm/Ptprc^tm1Holm Tg(LckF505)3073Rmp/? involves: 129/Sv C57BL/6 * DBA/2	increased T cell derived lymphoma incidence	J:64671
	thymus hyperplasia	J:64671
Ptprc^tm1Mak/Ptprc^tm1Mak Ptprj^tm1.2Weis/Ptprj^tm1.2Weis B6.Cg-Ptprc^tm1Mak Ptprj^tm1.2Weis	abnormal B cell differentiation	J:131736
	abnormal follicular B cell morphology	J:131736
	abnormal myelopoiesis	J:131736
	abnormal spleen morphology	J:131736
	abnormal transitional stage B cell morphology	J:131736
	anemia	J:131736
	decreased B cell number	J:131736
	decreased body weight	J:131736
	decreased immature B cell number	J:131736
	decreased mature B cell number	J:131736
	extramedullary hematopoiesis	J:131736
	liver inflammation	J:131736
	lung inflammation	J:131736
	premature death	J:131736
Ptprc^tm1Mak/Ptprc^tm1Mak Ptprj^tm1.2Weis/Ptprj^tm1.2Weis involves: 129/Sv * 129P2/OlaHsd * BALB/cJ * C57BL/6	abnormal B cell calcium ion homeostasis	J:131736
	abnormal cytokine secretion	J:131736
	abnormal follicular B cell morphology	J:131736
	abnormal myelopoiesis	J:131736
	decreased B cell number	J:131736
	impaired macrophage phagocytosis	J:131736
	premature death	J:131736
Ptprc^tm1Mak/Ptprc^tm1Mak Tg(TcraTcrb)425Cbn/0 involves: 129/Sv * BALB/c * C57BL/6	decreased CD4-positive, alpha-beta T cell number	J:158876

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