Rab1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rab1a
RAB1A, member RAS oncogene family
MGI:97842

17 phenotypes from 5 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rab1a^Gt(XB498)Byg/Rab1a⁺ B6.129P2-Rab1a^Gt(XB498)Byg	no abnormal phenotype detected	J:322487
Rab1a^Gt(XB498)Byg/Rab1a^Gt(XB498)Byg B6.129P2-Rab1a^Gt(XB498)Byg	embryonic lethality during organogenesis, complete penetrance	J:322487
Rab1a^{tm1b(KOMP)Wtsi}/Rab1a⁺ C57BL/6N-Rab1a^{tm1b(KOMP)Wtsi}/H	abnormal vibrissa morphology	J:211773
Rab1a^{tm1b(KOMP)Wtsi}/Rab1a^{tm1b(KOMP)Wtsi} C57BL/6N-Rab1a^{tm1b(KOMP)Wtsi}/H	preweaning lethality, complete penetrance	J:211773
Tg(Myh6-Rab1a)highGwd/0 involves: FVB/N	abnormal heart echocardiography feature	J:134581
	cardiac hypertrophy	J:134581
	congestive heart failure	J:134581
	decreased heart left ventricle muscle contractility	J:134581
	dilated cardiomyopathy	J:134581
	enlarged heart	J:134581
	increased heart weight	J:134581
	premature death	J:134581
Tg(Myh6-Rab1a)lowGwd/0 involves: FVB/N	abnormal heart echocardiography feature	J:134581
	decreased heart left ventricle muscle contractility	J:134581
	dilated cardiomyopathy	J:134581
	increased heart weight	J:134581
Tg(Myh6-Rab1a)medGwd/0 involves: FVB/N	abnormal myocardial fiber calcium currents	J:134581
	abnormal myocardial fiber morphology	J:134581
	cardiac hypertrophy	J:134581
	decreased calcium uptake by cardiac muscle	J:134581
	decreased heart left ventricle muscle contractility	J:134581
	decreased heart ventricle muscle contractility	J:134581
	dilated cardiomyopathy	J:134581
	increased myocardial fiber size	J:134581

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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