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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rac2
Rac family small GTPase 2
MGI:97846
43 phenotypes from 8 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rac2em1(IMPC)Mbp/Rac2em1(IMPC)Mbp
C57BL/6N-Rac2em1(IMPC)Mbp/Ucd 		abnormal liver morphology J:211773
Rac2em1Shl/Rac2+
involves: C57BL/6 		abnormal neutrophil morphology J:276213
decreased alpha-beta T cell number J:276213
decreased CD4-positive, alpha-beta T cell number J:276213
decreased CD8-positive, alpha-beta T cell number J:276213
decreased leukocyte cell number J:276213
decreased lymphocyte cell number J:276213
decreased T cell number J:276213
increased neutrophil cell number J:276213
oxidative stress J:276213
Rac2m1Btlr/Rac2+
C57BL/6J-Rac2m1Btlr 		decreased IgM level J:221478
impaired humoral immune response J:221478
Rac2m1Btlr/Rac2m1Btlr
C57BL/6J-Rac2m1Btlr 		decreased IgM level J:221478
impaired humoral immune response J:221478
Rac2M2Btlr/Rac2+
C57BL/6J-Rac2M2Btlr 		decreased B-1 B cell number J:231801
decreased B-1a cell number J:231801
increased B-1b cell number J:231801
Rac2M2Btlr/Rac2M2Btlr
C57BL/6J-Rac2M2Btlr 		decreased B-1 B cell number J:231801
decreased B-1a cell number J:231801
increased B-1b cell number J:231801
Rac2m3Btlr/Rac2+
C57BL/6J-Rac2m3Btlr 		decreased B-1a cell number J:236680
impaired hematopoiesis J:236680
increased B-1 B cell number J:236680
Rac2m3Btlr/Rac2m3Btlr
C57BL/6J-Rac2m3Btlr 		decreased B cell number J:236680
decreased B-1a cell number J:236680
decreased IgM level J:236680
decreased response to antigen J:236680
impaired hematopoiesis J:236680
increased B-1b cell number J:236680
increased neutrophil cell number J:236680
Rac2M4Btlr/Rac2+
C57BL/6J-Rac2M4Btlr 		abnormal cytotoxic T cell physiology J:255273
decreased alpha-beta T cell number J:255273
decreased CD4-positive, alpha-beta T cell number J:255273
decreased CD8-positive, alpha-beta T cell number J:255273
decreased CD8-positive, naive alpha-beta T cell number J:255273
decreased IgG level J:255273
decreased IgM level J:255273
impaired humoral immune response J:255273
impaired natural killer cell mediated cytotoxicity J:255273
increased alpha-beta T cell number J:255273
increased CD8-positive, alpha-beta T cell number J:255273
increased central memory CD8 positive, alpha-beta T cell number J:255273
increased effector memory CD4-positive, alpha-beta T cell number J:255273
increased effector memory CD8-positive, alpha-beta T cell number J:255273
increased IgM level J:255273
Rac2M4Btlr/Rac2M4Btlr
C57BL/6J-Rac2M4Btlr 		abnormal cytotoxic T cell physiology J:255273
decreased alpha-beta T cell number J:255273
decreased CD4-positive, alpha-beta T cell number J:255273
decreased CD8-positive, alpha-beta T cell number J:255273
decreased CD8-positive, naive alpha-beta T cell number J:255273
decreased IgE level J:255273
decreased IgG level J:255273
decreased IgM level J:255273
impaired humoral immune response J:255273
impaired natural killer cell mediated cytotoxicity J:255273
increased alpha-beta T cell number J:255273
increased CD8-positive, alpha-beta T cell number J:255273
increased central memory CD4-positive, alpha-beta T cell number J:255273
increased central memory CD8 positive, alpha-beta T cell number J:255273
increased effector memory CD4-positive, alpha-beta T cell number J:255273
increased effector memory CD8-positive, alpha-beta T cell number J:255273
Rac2M5Btlr/Rac2+
C57BL/6J-Rac2M5Btlr 		increased CD8-positive, alpha-beta T cell number J:255283
Rac2M5Btlr/Rac2M5Btlr
C57BL/6J-Rac2M5Btlr 		decreased B-1a cell number J:255283
increased B-1b cell number J:255283
increased CD8-positive, alpha-beta T cell number J:255283
Rac2tm1Mddw/Rac2tm1Mddw
B6.129S-Rac2tm1Mddw 		abnormal neutrophil physiology J:83457
Rac2tm1Mddw/Rac2tm1Mddw
involves: 129S/SvEv 		abnormal neutrophil physiology J:131305
abnormal wound healing J:131305
decreased angiogenesis J:131305
decreased vascular endothelial cell proliferation J:131305
delayed wound healing J:131305
Rac2tm1Mddw/Rac2tm1Mddw
involves: 129S/SvEv * C57BL/6 		abnormal granulocyte differentiation J:53362
abnormal neutrophil physiology J:53362
decreased leukocyte cell number J:53362
decreased neutrophil cell number J:53362
decreased T cell proliferation J:119437
impaired neutrophil chemotaxis J:53362
increased leukocyte cell number J:53362
increased neutrophil cell number J:53362
increased susceptibility to bacterial infection J:53362
increased susceptibility to induced morbidity/mortality J:53362
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory