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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Raf1
v-raf-leukemia viral oncogene 1
MGI:97847
33 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Braftm1Sva/Braf+
Raf1tm2Bacc/Raf1tm2Bacc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		no abnormal phenotype detected J:121660
Braftm1Sva/Braftm1.1Sva
Raf1tm1Bacc/Raf1tm2Bacc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal axon extension J:121660
abnormal dorsal root ganglion morphology J:121660
abnormal innervation J:121660
embryonic lethality during organogenesis, complete penetrance J:121660
Braftm1Sva/Braftm1Sva
Krastm1Bbd/Kras+
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased cell proliferation J:172200
Braftm1Sva/Braftm1Sva
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:172200
Braftm1Sva/Braftm1Sva
Raf1tm2Bacc/Raf1+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal dorsal root ganglion morphology J:121660
abnormal innervation J:121660
abnormal sensory neuron innervation pattern J:121660
postnatal growth retardation J:121660
postnatal lethality, incomplete penetrance J:121660
Braftm1Sva/Braftm1Sva
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal axon extension J:121660
Braftm1Wds/Braf+
Raf1tm2Bacc/Raf1tm2Bacc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		no abnormal phenotype detected J:121660
Braftm1Wds/Braftm1.1Wds
Raf1tm1Bacc/Raf1tm2Bacc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal axon extension J:121660
abnormal dorsal root ganglion morphology J:121660
abnormal innervation J:121660
embryonic lethality during organogenesis, complete penetrance J:121660
Braftm1Wds/Braftm1Wds
Raf1tm2Bacc/Raf1+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal dorsal root ganglion morphology J:121660
abnormal innervation J:121660
abnormal sensory neuron innervation pattern J:121660
postnatal growth retardation J:121660
postnatal lethality, incomplete penetrance J:121660
Braftm1Wds/Braftm1Wds
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * C57BL/6 		abnormal axon extension J:121660
Braftm1Wds/Braftm1Wds
Raf1tm2Bacc/Raf1tm2Bacc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * C57BL/6J * CBA/J 		abnormal conotruncus morphology J:144862
abnormal thyroid gland morphology J:144862
double outlet right ventricle J:144862
normal growth/size/body region phenotype J:144862
normal hearing/vestibular/ear phenotype J:144862
lethality throughout fetal growth and development, complete penetrance J:144862
mandible hypoplasia J:144862
persistent truncus arteriosus J:144862
short maxilla J:144862
small thymus J:144862
small thyroid gland J:144862
ventricular septal defect J:144862
Faslpr/Fas+
Raf1tm1Bacc/Raf1+
involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL 		normal hematopoietic system phenotype J:135681
Faslpr/Fas+
Raf1tm1Bacc/Raf1tm1Bacc
involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL 		abnormal erythropoiesis J:135681
normal hematopoietic system phenotype J:135681
normal mortality/aging J:135681
Faslpr/Faslpr
Raf1tm1Bacc/Raf1tm1Bacc
involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL 		abnormal erythropoiesis J:135681
increased apoptosis J:135681
Krastm1Bbd/Kras+
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased classified tumor incidence J:172200
premature death J:172200
Krastm1Bbd/Kras+
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased cell proliferation J:172200
Krastm4Tyj/Kras+
Raf1tm2Bacc/Raf1tm2Bacc
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129P2/OlaHsd * 129S4/SvJae 		increased pancreatic ductal adenocarcinoma incidence J:197054
Map3k5tm1Hijo/Map3k5tm1Hijo
Raf1tm2Bacc/Raf1tm2Bacc
Tg(Myh6-cre)2182Mds/0
involves: C57BL/6J 		normal cardiovascular system phenotype J:93418
Raf1TgTn(sb-cHS4,Tyr)2526AOve/Raf1TgTn(sb-cHS4,Tyr)2526AOve
FVB/N-Raf1TgTn(sb-cHS4,Tyr)2526AOve 		embryonic lethality during organogenesis J:175597
Raf1tm3Ulb/Raf1tm3Ulb
Not Specified 		decreased cell proliferation J:141095
embryonic growth retardation J:141095
embryonic lethality during organogenesis, complete penetrance J:141095
increased embryonic tissue cell apoptosis J:141095
increased sensitivity to induced cell death J:141095
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory