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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rag1
recombination activating 1
MGI:97848
77 phenotypes from 15 alleles in 23 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd79atm2(cre/Esr1*)Reth/Cd79a+
Rag1tm1.1Sadu/Rag1tm1.1Sadu
involves: BALB/c 		normal immune system phenotype J:155473
Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
involves: 129P2/OlaHsd * C57BL/6 		abnormal double-negative T cell morphology J:90487
abnormal double-positive T cell morphology J:90487
abnormal T cell morphology J:90487
decreased T cell number J:90487
Rag1coln/Rag1coln
C57BL/6JAnu-Rag1coln/AnuApb 		absent B cells J:104190
absent T cells J:104190
Rag1em2Mvw/Rag1em2Mvw
A/J-Rag1em2Mvw/MvwJ 		absent B cells J:332675
absent T cells J:332675
arrested B cell differentiation J:332675
arrested T cell differentiation J:332675
Rag1em3Mvw/Rag1em3Mvw
129S1/SvImJ-Rag1em3Mvw/MvwJ 		absent B cells J:332675
absent T cells J:332675
arrested B cell differentiation J:332675
arrested T cell differentiation J:332675
Rag1m1Anu/Rag1m1Anu
C57BL/6NCrlAnu-Rag1m1Anu 		decreased lymphocyte cell number J:104190
Rag1m1Btlr/Rag1m1Btlr
C57BL/6J-Rag1m1Btlr 		absent late pro-B cells J:150635
decreased CD4-positive, alpha-beta T cell number J:150635
decreased CD8-positive, alpha-beta T cell number J:150635
Rag1m2Btlr/Rag1m2Btlr
involves: C57BL/6J 		abnormal class switch recombination J:185495
decreased B cell number J:185495
decreased IgG level J:185495
decreased IgM level J:185495
decreased T cell number J:185495
Rag1m3Btlr/Rag1m3Btlr
C57BL/6J-Rag1m3Btlr 		increased central memory CD8 positive, alpha-beta T cell number J:272858
Rag1m4Btlr/Rag1m4Btlr
C57BL/6J-Rag1m4Btlr 		abnormal CD8-positive, alpha-beta T cell differentiation J:272094
abnormal T cell differentiation J:272094
decreased B cell number J:272094
decreased CD8-positive, naive alpha-beta T cell number J:272094
increased alpha-beta T cell number J:272094
increased CD8-positive, alpha-beta T cell number J:272094
increased central memory CD8 positive, alpha-beta T cell number J:272094
Rag1tm1(cre)Thr/Rag1tm1(cre)Thr
Not Specified 		abnormal lymphopoiesis J:86869
absent lymphocyte J:86869
Rag1tm1(GFP)Imku/Rag1tm1(GFP)Imku
involves: C57BL/6 * CBA 		abnormal immunoglobulin V(D)J recombination J:79416
Rag1tm1.1Sadu/Rag1tm1.1Sadu
involves: BALB/c 		arrested B cell differentiation J:155473
Rag1tm1Fwa/Rag1tm1Fwa
involves: 129 		abnormal B cell differentiation J:86464
abnormal T cell differentiation J:86464
decreased B cell number J:86464
increased double-negative T cell number J:86464
thymus hypoplasia J:86464
Rag1tm1Jsek/Rag1+
involves: 129S6/SvEvTac 		abnormal B cell differentiation J:146912
abnormal immunoglobulin heavy chain V(D)J recombination J:146912
abnormal T cell differentiation J:146912
abnormal T cell receptor beta chain V(D)J recombination J:146912
decreased double-positive T cell number J:146912
Rag1tm1Jsek/Rag1tm1Jsek
involves: 129S6/SvEvTac 		abnormal immunoglobulin heavy chain V(D)J recombination J:146912
abnormal immunoglobulin level J:146912
abnormal lymphopoiesis J:146912
abnormal T cell receptor beta chain V(D)J recombination J:146912
abnormal T cell receptor V(D)J recombination J:146912
absent immature B cells J:146912
absent mature B cells J:146912
arrested B cell differentiation J:146912
arrested T cell differentiation J:146912
decreased CD4-positive, alpha-beta T cell number J:146912
decreased CD8-positive, alpha-beta T cell number J:146912
decreased double-positive T cell number J:146912
decreased gamma-delta T cell number J:146912
increased double-negative T cell number J:146912
increased pro-B cell number J:146912
spontaneous chromosome breakage J:146912
thymus hypoplasia J:146912
Rag1tm1Mom/Rag1tm1Mom
B6.129S7-Rag1tm1Mom 		decreased IgM level J:78613
decreased immunoglobulin level J:111828
decreased vascular permeability J:78613
dermatitis J:111828
ear inflammation J:111828
epidermal hyperplasia J:111828
increased eosinophil cell number J:111828
mixed cellular infiltration to dermis J:111828
scaly skin J:111828
thick skin J:111828
Rag1tm1Mom/Rag1tm1Mom
B6.129S7-Rag1tm1Mom/J 		decreased anxiety-related response J:339075
Rag1tm1Mom/Rag1tm1Mom
C.129S7(B6)-Rag1tm1Mom/Tvg 		increased tumor incidence following infection J:329456
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd 		abnormal double-negative T cell morphology J:112990
abnormal neuron proliferation J:170591
abnormal thymus epithelium morphology J:125864
decreased inflammatory response J:94420
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * C57BL/6 		abnormal coat/hair pigmentation J:138466
abnormal eye morphology J:138466
abnormal lymphatic vessel morphology J:119344
abnormal respiratory system morphology J:119344
abnormal response to infection J:119344
abnormal retina morphology J:138466
abnormal skin pigmentation J:138466
autoimmune response J:138466
decreased neutrophil cell number J:119344
decreased susceptibility to induced colitis J:194587
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD 		decreased lymphocyte cell number J:111874
small thymus J:111874
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * C57BL/10 		abnormal bone remodeling J:129304
normal skeleton phenotype J:129304
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * CD-1 		abnormal B cell differentiation J:1934
abnormal immunoglobulin V(D)J recombination J:1934
abnormal inguinal lymph node morphology J:1934
abnormal T cell differentiation J:1934
abnormal T cell morphology J:1934
abnormal T cell receptor V(D)J recombination J:1934
absent mature B cells J:1934
normal behavior/neurological phenotype J:1934
decreased IgM level J:1934
normal nervous system phenotype J:1934
spleen hypoplasia J:1934
thymus hypoplasia J:1934
Rag1tm1Mom/Rag1tm1Mom
NOD.129S7(B6)-Rag1tm1Mom 		abnormal level of surface class II molecules J:109843
decreased CD4-positive, alpha-beta T cell number J:109843
decreased CD8-positive, alpha-beta T cell number J:109843
decreased immunoglobulin level J:109843
decreased mature B cell number J:109843
impaired natural killer cell mediated cytotoxicity J:109843
increased granulocyte number J:109843
increased immature B cell number J:109843
increased macrophage cell number J:109843
increased NK cell number J:109843
spleen hypoplasia J:109843
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory