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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rag2
recombination activating gene 2
MGI:97849
82 phenotypes from 11 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
involves: 129P2/OlaHsd * C57BL/6 		abnormal double-negative T cell morphology J:90487
abnormal double-positive T cell morphology J:90487
abnormal T cell morphology J:90487
decreased T cell number J:90487
Rag2m1Btlr/Rag2m1Btlr
C57BL/6J-Rag2m1Btlr 		abnormal humoral immune response J:203045
decreased B cell number J:203045
decreased CD4-positive, alpha-beta T cell number J:203045
decreased IgG level J:203045
decreased IgM level J:203045
Rag2tm1.1Cgn/Rag2tm1.1Cgn
C57BL/6-Rag2tm1.1Cgn 		arrested B cell differentiation J:72214
arrested T cell differentiation J:72214
Rag2tm1.1Desi/Rag2tm1.1Desi
involves: 129X1/SvJ * C57BL/6 		abnormal immunoglobulin V(D)J recombination J:168974
Rag2tm1Avla/Rag2tm1Avla
involves: 129/Sv * C57BL/6 		abnormal B cell physiology J:122108
abnormal digestive system morphology J:122108
abnormal immune system cell morphology J:122108
abnormal immune system organ morphology J:122108
abnormal lymph node morphology J:122108
abnormal lymphocyte physiology J:122108
abnormal spleen morphology J:122108
abnormal thymus morphology J:122108
absent Hassall's corpuscle J:122108
absent Peyer's patches J:122108
alopecia J:122108
arrested B cell differentiation J:122108
arrested T cell differentiation J:122108
cachexia J:122108
colitis J:122108
decreased double-positive T cell number J:122108
decreased IgA level J:122108
decreased IgG level J:122108
decreased lymphocyte cell number J:122108
decreased NK T cell number J:122108
decreased spleen white pulp amount J:122108
decreased T cell proliferation J:122108
erythroderma J:122108
small cervical lymph nodes J:122108
small inguinal lymph nodes J:122108
small lymph nodes J:122108
small spleen J:122108
Rag2tm1Cgn/Rag2tm1.1Cgn
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal B cell activation J:72214
absent immature B cells J:72214
absent pre-B cells J:72214
arrested B cell differentiation J:72214
arrested T cell differentiation J:72214
decreased follicular B cell number J:72214
decreased marginal zone B cell number J:72214
decreased mature B cell number J:72214
increased plasma cell number J:72214
Rag2tm1Cgn/Rag2tm1Cgn
C57BL/6-Rag2tm1Cgn 		no abnormal phenotype detected J:72214
Rag2tm1Fwa/Rag2tm1Fwa
either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6) 		abnormal intestinal epithelium morphology J:126867
Rag2tm1Fwa/Rag2tm1Fwa
involves: 129S/SvEv 		abnormal chemokine secretion J:140483
abnormal interferon secretion J:140483
abnormal macrophage physiology J:140483
abnormal response to transplant J:116136
abnormal T-helper 1 physiology J:116136
colitis J:116136
decreased susceptibility to bacterial infection induced morbidity/mortality J:140483
decreased thymocyte number J:114561
increased susceptibility to bacterial infection J:140483
lung inflammation J:140483
Rag2tm1Fwa/Rag2tm1Fwa
involves: 129S/SvEv * C57BL/6 		abnormal B cell morphology J:81133
abnormal intestinal mucosa morphology J:64232
abnormal stomach mucosa morphology J:64232
arrested T cell differentiation J:91542
decreased double-negative T cell number J:81133, J:91542
decreased susceptibility to parasitic infection J:64283
decreased susceptibility to type IV hypersensitivity reaction J:165513
increased double-negative T cell number J:91542
Rag2tm1Fwa/Rag2tm1Fwa
involves: 129S/SvEv * MF1 		abnormal effector T cell morphology J:1935
abnormal immunoglobulin V(D)J recombination J:1935
abnormal spleen morphology J:1935
abnormal T cell receptor V(D)J recombination J:1935
absent mature B cells J:1935
arrested B cell differentiation J:1935
arrested T cell differentiation J:1935
decreased body size J:1935
decreased CD4-positive, alpha-beta T cell number J:1935
decreased CD8-positive, alpha-beta T cell number J:1935
decreased double-positive T cell number J:1935
decreased IgM level J:1935
increased granulocyte number J:1935
increased macrophage cell number J:1935
increased natural killer cell mediated cytotoxicity J:1935
increased susceptibility to infection J:1935
lymph node hypoplasia J:1935
spleen hypoplasia J:1935
thymus hypoplasia J:1935
Rag2tm1Fwa/Rag2tm1Mao
involves: 129S/SvEv * C57BL/6 		abnormal B cell number J:81837
abnormal gamma-delta T cell differentiation J:81837
arrested B cell differentiation J:81837
arrested T cell differentiation J:81837
decreased double-negative T cell number J:81837
decreased immature B cell number J:81837
decreased mature B cell number J:81837
decreased pre-B cell number J:81837
increased immature B cell number J:81837
thymus hypoplasia J:81837
Rag2tm1Libo/Rag2tm1Libo
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal B cell differentiation J:84563
abnormal B cell physiology J:84563
decreased B cell number J:84563
decreased bone marrow cell number J:84563
decreased monocyte cell number J:84563
decreased pre-B cell number J:84563
Rag2tm1Mao/Rag2tm1Mao
involves: 129 * C57BL/6 		abnormal B cell number J:81837
abnormal gamma-delta T cell differentiation J:81837
arrested B cell differentiation J:81837
arrested T cell differentiation J:81837
decreased double-negative T cell number J:81837
decreased immature B cell number J:81837
decreased mature B cell number J:81837
decreased pre-B cell number J:81837
increased immature B cell number J:81837
thymus hypoplasia J:81837
Rag2tm1Mao/Rag2tm1Mao
involves: 129S6/SvEvTac * C57BL/6 		abnormal immune system cell morphology J:81837
Rag2tm1Tgi/Rag2tm1Tgi
involves: 129S1/Sv * 129X1/SvJ 		abnormal Peyer's patch morphology J:113641
arrested B cell differentiation J:113641
arrested T cell differentiation J:113641
decreased B cell number J:113641
decreased double-positive T cell number J:113641
decreased thymocyte number J:113641
Rag2tm2Fwa/Rag2tm2Fwa
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:57268
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory