Rad51 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rad51
RAD51 recombinase
MGI:97890

23 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rad51^tm1Csha/Rad51^tm1Csha Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺ involves: 129S/Sv * C57BL/6J	abnormal double-strand DNA break repair	J:324159
	abnormal male meiosis	J:324159
	abnormal spermatocyte morphology	J:324159
	abnormal spermatogenesis	J:324159
	decreased male germ cell number	J:324159
	decreased testis weight	J:324159
	increased male germ cell apoptosis	J:324159
	small testis	J:324159
Rad51^tm1Csha/Rad51^tm1Csha Tg(Ddx4-cre)1Dcas/0 involves: C57BL/6J * FVB	abnormal male meiosis	J:324159
	abnormal seminiferous tubule morphology	J:324159
	abnormal spermatocyte morphology	J:324159
	abnormal spermatogenesis	J:324159
	abnormal spermatogonia morphology	J:324159
	decreased male germ cell number	J:324159
	decreased testis weight	J:324159
	increased Sertoli cell number	J:324159
	male infertility	J:324159
	small testis	J:324159
Rad51^tm1Hst/Rad51^tm1Hst involves: 129S7/SvEvBrd * C57BL/6	abnormal embryonic tissue morphology	J:36540
	absent amniotic cavity	J:36540
	absent inner cell mass proliferation	J:36540
	absent mesoderm	J:36540
	decreased cell proliferation	J:36540
	decreased embryo size	J:36540
	embryonic growth arrest	J:36540
	embryonic lethality between implantation and somite formation, complete penetrance	J:36540
	increased cellular sensitivity to gamma-irradiation	J:36540
	increased embryonic epiblast cell apoptosis	J:36540
Rad51^tm1Tkm/Rad51^tm1Tkm involves: 129S/SvEv	embryonic lethality before implantation, complete penetrance	J:33832

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24