Rad51 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rad51
RAD51 recombinase
MGI:97890

23 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rad51^tm1Csha/Rad51^tm1Csha Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺ involves: 129S/Sv * C57BL/6J	abnormal double-strand DNA break repair	J:324159
	abnormal male meiosis	J:324159
	abnormal spermatocyte morphology	J:324159
	abnormal spermatogenesis	J:324159
	decreased male germ cell number	J:324159
	decreased testis weight	J:324159
	increased male germ cell apoptosis	J:324159
	small testis	J:324159
Rad51^tm1Csha/Rad51^tm1Csha Tg(Ddx4-cre)1Dcas/0 involves: C57BL/6J * FVB	abnormal male meiosis	J:324159
	abnormal seminiferous tubule morphology	J:324159
	abnormal spermatocyte morphology	J:324159
	abnormal spermatogenesis	J:324159
	abnormal spermatogonia morphology	J:324159
	decreased male germ cell number	J:324159
	decreased testis weight	J:324159
	increased Sertoli cell number	J:324159
	male infertility	J:324159
	small testis	J:324159
Rad51^tm1Hst/Rad51^tm1Hst involves: 129S7/SvEvBrd * C57BL/6	abnormal embryonic tissue morphology	J:36540
	absent amniotic cavity	J:36540
	absent inner cell mass proliferation	J:36540
	absent mesoderm	J:36540
	decreased cell proliferation	J:36540
	decreased embryo size	J:36540
	embryonic growth arrest	J:36540
	embryonic lethality between implantation and somite formation, complete penetrance	J:36540
	increased cellular sensitivity to gamma-irradiation	J:36540
	increased embryonic epiblast cell apoptosis	J:36540
Rad51^tm1Tkm/Rad51^tm1Tkm involves: 129S/SvEv	embryonic lethality before implantation, complete penetrance	J:33832

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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