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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ren1
renin 1 structural
MGI:97898
69 phenotypes from 10 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ren1tm1.1Sig/Ren1tm1.1Sig
Tg(GFAP-cre)25Mes/0
involves: C57BL/6J * FVB/N 		normal cardiovascular system phenotype J:168753
normal homeostasis/metabolism phenotype J:168753
normal mortality/aging J:168753
normal renal/urinary system phenotype J:168753
Ren1tm1.1Sig/Ren1tm1.1Sig
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * C57BL/6J * SJL 		normal cardiovascular system phenotype J:168753
normal homeostasis/metabolism phenotype J:168753
normal mortality/aging J:168753
normal renal/urinary system phenotype J:168753
Ren1tm1.2Sig/Ren1tm1.2Sig
involves: C57BL/6J 		abnormal baroreceptor physiology J:169129
decreased hematocrit J:169129
decreased mean systemic arterial blood pressure J:169129
decreased physiological sensitivity to xenobiotic J:169129
decreased urine osmolality J:169129
decreased vasoconstriction J:169129
increased circulating aldosterone level J:169129
kidney atrophy J:169129
polyuria J:169129
postnatal lethality, complete penetrance J:169129
Ren1tm1Afu/Ren1tm1Afu
involves: C57BL/6 * CBA 		abnormal blood homeostasis J:59299
abnormal innervation J:59299
abnormal juxtaglomerular apparatus morphology J:59299
abnormal juxtaglomerular cell morphology J:59299
abnormal macula densa morphology J:59299
normal cardiovascular system phenotype J:59299
decreased circulating renin level J:59299
decreased systemic arterial blood pressure J:59299
decreased systemic arterial diastolic blood pressure J:59299
decreased systemic arterial systolic blood pressure J:59299
hydronephrosis J:59299
kidney atrophy J:59299
polydipsia J:59299
polyuria J:59299
postnatal lethality, complete penetrance J:59299
vascular smooth muscle hyperplasia J:59299
Ren1tm1Bjm/Ren1tm1Bjm
B6.Cg-Ren1tm1Bjm 		abnormal locomotor behavior J:117294
abnormal macula densa morphology J:117294
normal cardiovascular system phenotype J:117294
decreased mean systemic arterial blood pressure J:117294
decreased renal glomerular filtration rate J:117294
decreased systemic arterial diastolic blood pressure J:117294
decreased systemic arterial systolic blood pressure J:117294
hypotension J:117294
increased circulating creatinine level J:117294
increased heart rate J:117294
normal nervous system phenotype J:117294
Ren1tm1Gom/Ren1tm1Gom
involves: 129S6/SvEvTac 		abnormal juxtaglomerular cell morphology J:72077
decreased circulating renin level J:72077
decreased systemic arterial blood pressure J:72077
Ren1tm1Mgfs/Ren1tm1Mgfs
involves: 129P2/OlaHsd 		abnormal blood homeostasis J:41714
abnormal juxtaglomerular cell morphology J:41714
abnormal macula densa morphology J:41714
decreased circulating renin level J:41714
decreased systemic arterial blood pressure J:41714
Ren1tm1Tkh/Ren1+
C57BL/6-Ren1tm1Tkh 		no abnormal phenotype detected J:110082
Ren1tm1Tkh/Ren1tm1Tkh
C57BL/6-Ren1tm1Tkh 		abnormal kidney afferent arteriole morphology J:110082
abnormal kidney interlobular artery morphology J:110082
abnormal urine homeostasis J:110082
decreased body weight J:110082
decreased circulating angiotensin II level J:110082
decreased circulating renin level J:110082
decreased systemic arterial blood pressure J:110082
decreased urine osmolality J:110082
dehydration J:110082
glomerulosclerosis J:110082
granular kidney J:110082
hydronephrosis J:110082
increased blood urea nitrogen level J:110082
increased circulating creatinine level J:110082
kidney inflammation J:110082
kidney medulla atrophy J:110082
kidney papillary atrophy J:110082
kidney papillary hypoplasia J:110082
metabolic acidosis J:110082
polyuria J:110082
postnatal lethality, incomplete penetrance J:110082
renal interstitial fibrosis J:110082
normal reproductive system phenotype J:110082
small kidney J:110082
Ren1tm3Gom/Ren1+
129S6/SvEvTac-Ren1tm3Gom 		abnormal juxtaglomerular cell morphology J:95786
decreased circulating renin level J:95786
Ren1tm3Gom/Ren1tm3Gom
129S6/SvEvTac-Ren1tm3Gom 		abnormal juxtaglomerular cell morphology J:95786
abnormal kidney cortex morphology J:95786
abnormal kidney medulla morphology J:95786
abnormal renal glomerulus morphology J:95786
decreased circulating renin level J:95786
decreased kidney weight J:95786
decreased systemic arterial blood pressure J:95786
dilated renal tubule J:95786
granular kidney J:95786
increased blood urea nitrogen level J:95786
increased circulating potassium level J:95786
kidney atrophy J:95786
kidney cortex atrophy J:95786
proximal convoluted tubule brush border loss J:95786
renal glomerulus atrophy J:95786
renal glomerulus fibrosis J:95786
renal glomerulus hypertrophy J:95786
renal interstitial fibrosis J:95786
renal tubule atrophy J:95786
small kidney J:95786
Tg(Alb1-Ren)1Unc/0
involves: 129S6/SvEvTac * C57BL/6 		albuminuria J:89252
decreased urine osmolality J:89252
hypertension J:89252
increased circulating creatinine level J:89252
kidney inflammation J:89252
polydipsia J:89252
polyuria J:89252
Tg(Alb1-Ren)2Unc/?
129S6/SvEvTac-Tg(Alb1-Ren)2Unc 		increased systemic arterial blood pressure J:125933
Tg(Alb1-Ren)2Unc/0
involves: 129S6/SvEvTac * C57BL/6 		albuminuria J:89252
cardiac hypertrophy J:88650
decreased heart rate J:88650
decreased urine osmolality J:89252
hypertension J:88650, J:89252
increased circulating creatinine level J:89252
kidney inflammation J:89252
polydipsia J:89252
polyuria J:89252
premature death J:88650
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory