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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ret
ret proto-oncogene
MGI:97902
125 phenotypes from 32 alleles in 33 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mnx1tm4(cre)Tmj/Mnx1+
Rettm2(RET)Heno/Rettm2(RET)Heno
involves: 129S1/Sv * C57BL/6 * SJL 		normal nervous system phenotype J:132854
Mnx1tm4(cre)Tmj/Mnx1+
Rettm2(RET)Heno/Rettm2(RET)Heno
involves: C57BL/6 * SJL 		abnormal motor neuron innervation pattern J:132854
decreased motor neuron number J:132854
Nkx6-2tm2(cre)Ercs/Nkx6-2+
Rettm1.1Pern/Rettm1.1Pern
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal facial motor nucleus morphology J:131770
abnormal hypoglossal nucleus morphology J:131770
abnormal neuromuscular synapse morphology J:131770
normal renal/urinary system phenotype J:131770
Rettm1.1Ddg/Rettm1.1Ddg
involves: 129 		abnormal neuron morphology J:154926
Rettm1.1Kln/Rettm1.1Kln
involves: 129/Sv * BALB/c * C57BL/6 * CBA/J 		abnormal innervation pattern to muscle J:110955
Rettm1.1Pern/Rettm1.1Pern
involves: 129P2/OlaHsd * C57BL/6 * SJL 		no abnormal phenotype detected J:131770
Rettm1.1Vlcg/Rettm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac 		no abnormal phenotype detected J:200671
Rettm1.2Pern/Rettm1.2Pern
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL 		abnormal kidney development J:131770
abnormal neuromuscular synapse morphology J:131770
perinatal lethality, complete penetrance J:131770
Rettm1Cos/Ret+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ 		decreased renal glomerulus number J:117753
single kidney J:117753
Rettm1Cos/Ret+
involves: 129S/SvEv * C57BL/6 		abnormal enteric neuron morphology J:82456
abnormal neurotransmitter secretion J:82456
intestinal hypoperistalsis J:82456
Rettm1Cos/Rettm1Cos
involves: 129S/Sv * C57BL/6 		abnormal enteric ganglia morphology J:135153
abnormal enteric nervous system morphology J:135153
absent kidney J:135153
Rettm1Cos/Rettm1Cos
involves: 129S/SvEv 		normal endocrine/exocrine gland phenotype J:82111
Rettm1Cos/Rettm1Cos
involves: 129S/SvEv * MF1 		abnormal branching involved in ureteric bud morphogenesis J:84282
abnormal cardiac ganglion morphology J:64539
abnormal enteric neural crest cell migration J:30830
abnormal kidney collecting duct morphology J:23852
abnormal kidney mesenchyme morphology J:23852
abnormal kidney morphology J:23852, J:30389
abnormal lung development J:30389
abnormal mesonephros morphology J:84282
abnormal metanephric mesenchyme morphology J:84282
abnormal parasympathetic postganglionic fiber morphology J:64539
abnormal stellate ganglion morphology J:30830
abnormal ureter development J:23852
abnormal ureter morphology J:23852, J:30389
abnormal ureteric bud elongation J:84282
abnormal ureteric bud invasion J:84282
absent enteric neurons J:23852, J:30389, J:30830
absent kidney J:23852, J:30389
absent nephrogenic zone J:23852
absent superior cervical ganglion J:30830
absent ureter J:23852, J:30389
blind ureter J:23852, J:30389
normal cardiovascular system phenotype J:64539
dilated renal glomerular capsule J:30389
dilated renal tubule J:30389
increased metanephric mesenchyme apoptosis J:84282
intestinal hypoperistalsis J:23852, J:30389
neonatal lethality, complete penetrance J:23852, J:30389
oligohydramnios J:30389
small kidney J:30389
Rettm1Cos/Rettm2.1Cos
involves: 129S/SvEv * 129S1/Sv * C57BL/6J * FVB/N * MF1 		normal endocrine/exocrine gland phenotype J:60659
normal neoplasm J:60659
normal reproductive system phenotype J:60659
Rettm1Cti/Ret+
involves: 129S/SvEv * C57BL/6J 		abnormal enteric neuron morphology J:107335
abnormal large intestine morphology J:107335
abnormal small intestine morphology J:107335
Rettm1Cti/Rettm1Cti
involves: 129S/SvEv * C57BL/6J 		abnormal enteric ganglia morphology J:107335
abnormal urinary bladder morphology J:107335
absent enteric neurons J:107335
absent kidney J:107335
neonatal lethality, complete penetrance J:107335
Rettm1Ddg/Rettm1Ddg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129 * C57BL/6 * C57BL/6J * CBA/J 		abnormal jejunum morphology J:126484
abnormal neuron morphology J:126484
absent enteric neurons J:126484
aganglionic megacolon J:126484
distended abdomen J:126484
enlarged ileum J:126484
postnatal lethality, incomplete penetrance J:126484
small dorsal root ganglion J:126484
weakness J:126484
Rettm1Giro/Ret+
129.129P2-Rettm1Giro 		abnormal thyroid gland morphology J:141658
adrenal cortical hyperplasia J:141658
increased thyroid adenoma incidence J:141658
Rettm1Giro/Ret+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		adrenal cortical hyperplasia J:141658
Rettm1Giro/Rettm1Giro
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal enteric ganglia morphology J:141658
abnormal neuron differentiation J:141658
absent kidney J:141658
neonatal lethality, complete penetrance J:141658
normal nervous system phenotype J:141658
Rettm1Heno/Rettm1Heno
Not Specified 		abnormal gastrocnemius morphology J:132854
abnormal hypaxial muscle morphology J:132854
abnormal motor neuron innervation pattern J:132854
abnormal muscle spindle morphology J:132854
decreased motor neuron number J:132854
Rettm1Heno/Rettm2(RET)Heno
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal enteric neuron morphology J:159854
Rettm1Jmi/Ret+
involves: 129X1/SvJ 		impaired branching involved in ureteric bud morphogenesis J:213514
Rettm1Jmi/Rettm1Jmi
involves: 129X1/SvJ 		abnormal innervation J:106244
abnormal prevertebral ganglion morphology J:71881
abnormal submandibular gland morphology J:71881
abnormal sympathetic ganglion morphology J:71881
abnormal sympathetic neuron morphology J:71881
abnormal sympathetic postganglionic fiber morphology J:71881
absent enteric neurons J:71881
absent kidney J:71881
increased cell proliferation J:71881
increased neuron apoptosis J:71881
neonatal lethality, complete penetrance J:71881
small superior cervical ganglion J:71881
Rettm1Kln/Rettm1Kln
Slc6a3tm1(cre)Xz/Slc6a3+
involves: 129S1/Sv 		abnormal synaptic dopamine release J:188348
loss of dopaminergic neurons J:188348
Rettm1Kln/Rettm1Kln
Tg(Nes-cre)1Kln/0
involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL 		abnormal innervation pattern to muscle J:110955
clubfoot J:110955
Rettm1Mat/Rettm1Mat
involves: 129X1/SvJ * C57BL/6J 		abnormal colon morphology J:92802
abnormal enteric ganglia morphology J:92802
abnormal enteric nervous system morphology J:92802
abnormal small intestine morphology J:92802
abnormal ureteric bud morphology J:92802
decreased kidney weight J:92802
distended abdomen J:92802
kidney cyst J:92802
postnatal growth retardation J:92802
postnatal lethality, complete penetrance J:92802
Rettm2(cre/ERT2)Ddg/Ret+
Not Specified 		no abnormal phenotype detected J:157722
Rettm2(RET)Heno/Rettm1Cos
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S/Sv * C57BL/6 * CBA 		abnormal enteric ganglia morphology J:135153
Rettm2.1Cos/Ret+
involves: 129S1/Sv * C57BL/6J * FVB/N 		adrenergic chromaffin cell hyperplasia J:60659
thyroid gland hyperplasia J:60659
Rettm2.1Cos/Rettm2.1Cos
involves: 129S1/Sv 		normal immune system phenotype J:195828
Rettm2.1Cos/Rettm2.1Cos
involves: 129S1/Sv * C57BL/6J 		increased pheochromocytoma incidence J:148708
Rettm2.1Cos/Rettm2.1Cos
involves: 129S1/Sv * C57BL/6J * FVB/N 		abnormal adrenal gland morphology J:60659
abnormal adrenal medulla morphology J:60659
abnormal sympathetic ganglion morphology J:60659
adrenergic chromaffin cell hyperplasia J:60659
increased ganglioneuroma incidence J:60659
increased pheochromocytoma incidence J:60659
male infertility J:60659
thyroid gland hyperplasia J:60659
Rettm2.1Heno/Rettm2.1Heno
involves: 129S/Sv * C57BL/6 * FVB/N 		abnormal enteric nervous system morphology J:135153
absent kidney J:135153
increased neuron apoptosis J:135153
Rettm2.1Heno/Rettm2.1Heno
involves: C57BL/6 * FVB/N * SJL 		abnormal gastrocnemius morphology J:132854
abnormal hypaxial muscle morphology J:132854
abnormal motor neuron innervation pattern J:132854
abnormal muscle spindle morphology J:132854
decreased motor neuron number J:132854
muscular atrophy J:132854
Rettm2Cos/Rettm2Cos
involves: 129S1/Sv 		abnormal intestinal peristalsis J:60659
absent kidney J:60659
neonatal lethality, complete penetrance J:60659
Rettm3(RET)Jmi/Ret+
Not Specified 		no abnormal phenotype detected J:93262
Rettm3.1(RET)Jmi/Ret+
Not Specified 		abnormal colon morphology J:93262
abnormal enteric ganglia morphology J:93262
abnormal enteric nervous system morphology J:93262
abnormal kidney development J:93262
abnormal pterygopalatine ganglion morphology J:93262
abnormal spermatogenesis J:93262
arrest of spermatogenesis J:93262
decreased renal glomerulus number J:93262
distended ileum J:93262
kidney cyst J:93262
premature death J:93262
renal cast J:93262
renal hypoplasia J:93262
seminiferous tubule degeneration J:93262
Rettm3Cos/Rettm3Cos
involves: 129S1/Sv * FVB/N 		abnormal colon morphology J:116089
abnormal enteric ganglia morphology J:116089
abnormal enteric neural crest cell migration J:116089
abnormal enteric neural crest cell morphology J:116089
abnormal enteric neuron morphology J:116089
abnormal enzyme/coenzyme activity J:116089
absent enteric neurons J:116089
Rettm4(RET)Jmi/Rettm4(RET)Jmi
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 		dilated ureter J:105047
hydronephrosis J:105047
Rettm6.1Vpa/Rettm6.2Vpa
Tg(CD2-icre)4Kio/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca 		normal hematopoietic system phenotype J:195828
normal immune system phenotype J:195828
Rettm7(RET)Jmi/Rettm7(RET)Jmi
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 		large ureter J:105047
Rettm8(RET)Jmi/Rettm8(RET)Jmi
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 		abnormal kidney morphology J:105047
abnormal ureter morphology J:105047
abnormal ureteric bud morphology J:105047
abnormal vas deferens morphology J:105047
dilated ureter J:105047
ectopic ovary J:105047
ectopic testis J:105047
ectopic ureteric bud J:105047
impaired branching involved in ureteric bud morphogenesis J:105047
kidney cyst J:105047
large ureter J:105047
renal hypoplasia J:105047
Rettm9(RET)Jmi/Rettm9(RET)Jmi
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 		abnormal kidney development J:105047
abnormal kidney morphology J:105047
absent kidney J:105047
absent nephrogenic zone J:105047
decreased renal glomerulus number J:105047
kidney cyst J:105047
single kidney J:105047
Rettm9(RET)Jmi/Rettm12(RET)Jmi
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 		normal renal/urinary system phenotype J:105047
Rettm10(RET)Jmi/Rettm10(RET)Jmi
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 		normal renal/urinary system phenotype J:105047
Rettm11(RET)Jmi/Rettm11(RET)Jmi
involves: 129S1/Sv * 129X1/SvJ 		normal nervous system phenotype J:132854
Rettm11(RET)Jmi/Rettm11(RET)Jmi
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 		abnormal kidney development J:105047
abnormal kidney medulla development J:105047
abnormal kidney morphology J:105047
abnormal renal glomerulus morphology J:105047
abnormal ureter morphology J:105047
abnormal ureteric bud morphology J:105047
absent kidney cortex J:105047
absent kidney medulla J:105047
cryptorchism J:105047
decreased renal glomerulus number J:105047
dilated ureter J:105047
ectopic kidney J:105047
ectopic ovary J:105047
ectopic ureteric bud J:105047
glomerulosclerosis J:105047
hydronephrosis J:105047
impaired branching involved in ureteric bud morphogenesis J:105047
increased kidney apoptosis J:105047
kidney atrophy J:105047
kidney cyst J:105047
large ureter J:105047
premature death J:105047
renal hypoplasia J:105047
ureter obstruction J:105047
ureter stenosis J:105047
Rettm11(RET)Jmi/Rettm12(RET)Jmi
involves: 129S1/Sv * 129X1/SvJ 		abnormal hypaxial muscle morphology J:132854
abnormal motor neuron innervation pattern J:132854
abnormal muscle spindle morphology J:132854
decreased motor neuron number J:132854
muscular atrophy J:132854
Rettm12(RET)Jmi/Rettm12(RET)Jmi
involves: 129S1/Sv * 129X1/SvJ 		abnormal hypaxial muscle morphology J:132854
abnormal motor neuron innervation pattern J:132854
abnormal muscle spindle morphology J:132854
decreased motor neuron number J:132854
muscular atrophy J:132854
Rettm12(RET)Jmi/Rettm12(RET)Jmi
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 		dilated ureter J:105047
Rettm13.1Jmi/Rettm13.1Jmi
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal enteric neuron morphology J:114682
absent enteric neurons J:114682
absent kidney J:114682
normal nervous system phenotype J:114682
Rettm14(Gfra1)Jmi/Ret+
involves: 129X1/SvJ 		no abnormal phenotype detected J:130616
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory