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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rheb
Ras homolog enriched in brain
MGI:97912
39 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw/Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal cerebral cortex morphology J:168571
hypermyelination J:168571
increased brain size J:168571
increased brain weight J:168571
increased oligodendrocyte number J:168571
neuron hypertrophy J:168571
thickened cerebral cortex J:168571
Rhebtm1.1Otsu/Rhebtm1.1Otsu
involves: 129 * C57BL/6J 		no abnormal phenotype detected J:197831
Rhebtm1.1Otsu/Rhebtm1.1Otsu
Tg(Myh6-cre)2182Mds/0
involves: 129 * C57BL/6J * FVB/N 		abnormal heart left ventricle morphology J:197831
abnormal sarcomere morphology J:197831
cardiomyopathy J:197831
decreased cardiac muscle contractility J:197831
decreased heart weight J:197831
decreased myocardial fiber size J:197831
postnatal lethality, complete penetrance J:197831
thin interventricular septum J:197831
Rhebtm1.1Pfw/Rhebtm1.1Pfw
involves: C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:168571
Rhebtm1.1Yelg/Rhebtm1.1Yelg
B6.129P2-Rhebtm1.1Yelg 		abnormal heart development J:170999
decreased embryo size J:170999
decreased fibroblast proliferation J:170999
embryo tissue necrosis J:170999
embryonic growth retardation J:170999
embryonic lethality during organogenesis, complete penetrance J:170999
hemopericardium J:170999
increased embryonic tissue cell apoptosis J:170999
thin ventricular wall J:170999
Rhebtm1Pfw/Rhebtm1Pfw
Tg(Amh-cre)8815Reb/0
involves: 129S1/SvImJ * FVB/N 		abnormal seminiferous tubule morphology J:268375
decreased epididymis weight J:268375
decreased testis weight J:268375
oligozoospermia J:268375
normal reproductive system phenotype J:268375
Rhebtm1Pfw/Rhebtm1Pfw
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		normal immune system phenotype J:150108
Rhebtm1Pfw/Rhebtm1Pfw
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal brain development J:168571
abnormal myelin sheath morphology J:168571
decreased brain weight J:168571
decreased oligodendrocyte number J:168571
demyelination J:168571
postnatal growth retardation J:168571
premature death J:168571
thin cerebral cortex J:168571
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory