Rpe65 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rpe65
retinal pigment epithelium 65
MGI:98001

31 phenotypes from 8 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rpe65^450L/Rpe65^450L BALB/c	retina outer nuclear layer degeneration	J:154536
Rpe65^450L/Rpe65^450L BALB/c	thin retina outer nuclear layer	J:154536
Rpe65^450M/Rpe65^450M C57BL/6J-Tyr^c-2J	abnormal eye physiology	J:86186
Rpe65^rd12-2J/Rpe65^rd12-2J B6.Cg-Rpe65^rd12-2J/BocJ	abnormal cone electrophysiology	J:346129
	abnormal rod electrophysiology	J:346129
	decreased a-wave amplitude	J:346129
	decreased b-wave implicit time	J:346129
	retina degeneration	J:346129
	retina spots	J:346129
Rpe65^rd12/Rpe65^rd12 B6(A)-Rpe65^rd12/J	abnormal cone electrophysiology	J:94549
	abnormal eye electrophysiology	J:94549
	abnormal retina rod cell outer segment morphology	J:94549
	abnormal rod electrophysiology	J:94549
	increased susceptibility to age-related retinal degeneration	J:94549
	retina spots	J:348118
	thin retina outer nuclear layer	J:94549
Rpe65^{tm1a(EUCOMM)Hmgu}/Rpe65^{tm1a(EUCOMM)Hmgu} C57BL/6N-Rpe65^{tm1a(EUCOMM)Hmgu}/H	abnormal pupil morphology	J:165965
	abnormal retina morphology	J:165965
	decreased leukocyte cell number	J:165965
	decreased locomotor activity	J:165965
	hyperactivity	J:165965
	increased leukocyte cell number	J:165965
	limb grasping	J:165965
Rpe65^tm1Lrcb/Rpe65^tm1Lrcb 129S6/SvEvTac-Rpe65^tm1Lrcb	abnormal photoreceptor outer segment morphology	J:130076
	abnormal retina pigment epithelium morphology	J:130076
	abnormal rod electrophysiology	J:130076
	abnormal vitamin A metabolism	J:130076
	delayed dark adaptation	J:130076
	disorganized photoreceptor outer segment	J:130076
	photoreceptor outer segment degeneration	J:130076
	retina outer nuclear layer degeneration	J:130076
	short photoreceptor outer segment	J:130076
Rpe65^tm1Tmr/Rpe65^tm1Tmr B6.129-Rpe65^tm1Tmr/BocJ	retina spots	J:348118
Rpe65^tm1Tmr/Rpe65^tm1Tmr involves: 129S1/Sv * 129X1/SvJ	retina cone cell degeneration	J:136882
	retina photoreceptor degeneration	J:136882
	retina rod cell degeneration	J:136882
	short photoreceptor outer segment	J:136882
Rpe65^tm1Tmr/Rpe65^tm1Tmr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal eye physiology	J:51293, J:61889
	abnormal retina pigment epithelium morphology	J:130076
	abnormal retina rod cell outer segment morphology	J:51293
	abnormal rod electrophysiology	J:51293, J:71529, J:85796
	abnormal vitamin A metabolism	J:130076
	disorganized photoreceptor outer segment	J:130076
	photoreceptor outer segment degeneration	J:130076
	retina degeneration	J:51293
	retina outer nuclear layer degeneration	J:130076
	retina rod cell degeneration	J:81027
	short photoreceptor outer segment	J:130076
	thin retina outer nuclear layer	J:51293
Rpe65^tvrm148/Rpe65^tvrm148 C57BL/6J-Rpe65^tvrm148/J	abnormal cone electrophysiology	J:166679
	abnormal retina pigmentation	J:166679
	abnormal rod electrophysiology	J:166679
	retina photoreceptor degeneration	J:166679
	retina spots	J:166679
	short photoreceptor inner segment	J:166679
	short photoreceptor outer segment	J:166679

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24