Rpe65 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rpe65
retinal pigment epithelium 65
MGI:98001

31 phenotypes from 8 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rpe65^450L/Rpe65^450L BALB/c	retina outer nuclear layer degeneration	J:154536
Rpe65^450L/Rpe65^450L BALB/c	thin retina outer nuclear layer	J:154536
Rpe65^450M/Rpe65^450M C57BL/6J-Tyr^c-2J	abnormal eye physiology	J:86186
Rpe65^rd12-2J/Rpe65^rd12-2J B6.Cg-Rpe65^rd12-2J/BocJ	abnormal cone electrophysiology	J:346129
	abnormal rod electrophysiology	J:346129
	decreased a-wave amplitude	J:346129
	decreased b-wave implicit time	J:346129
	retina degeneration	J:346129
	retina spots	J:346129
Rpe65^rd12/Rpe65^rd12 B6(A)-Rpe65^rd12/J	abnormal cone electrophysiology	J:94549
	abnormal eye electrophysiology	J:94549
	abnormal retina rod cell outer segment morphology	J:94549
	abnormal rod electrophysiology	J:94549
	increased susceptibility to age-related retinal degeneration	J:94549
	retina spots	J:348118
	thin retina outer nuclear layer	J:94549
Rpe65^{tm1a(EUCOMM)Hmgu}/Rpe65^{tm1a(EUCOMM)Hmgu} C57BL/6N-Rpe65^{tm1a(EUCOMM)Hmgu}/H	abnormal pupil morphology	J:165965
	abnormal retina morphology	J:165965
	decreased leukocyte cell number	J:165965
	decreased locomotor activity	J:165965
	hyperactivity	J:165965
	increased leukocyte cell number	J:165965
	limb grasping	J:165965
Rpe65^tm1Lrcb/Rpe65^tm1Lrcb 129S6/SvEvTac-Rpe65^tm1Lrcb	abnormal photoreceptor outer segment morphology	J:130076
	abnormal retina pigment epithelium morphology	J:130076
	abnormal rod electrophysiology	J:130076
	abnormal vitamin A metabolism	J:130076
	delayed dark adaptation	J:130076
	disorganized photoreceptor outer segment	J:130076
	photoreceptor outer segment degeneration	J:130076
	retina outer nuclear layer degeneration	J:130076
	short photoreceptor outer segment	J:130076
Rpe65^tm1Tmr/Rpe65^tm1Tmr B6.129-Rpe65^tm1Tmr/BocJ	retina spots	J:348118
Rpe65^tm1Tmr/Rpe65^tm1Tmr involves: 129S1/Sv * 129X1/SvJ	retina cone cell degeneration	J:136882
	retina photoreceptor degeneration	J:136882
	retina rod cell degeneration	J:136882
	short photoreceptor outer segment	J:136882
Rpe65^tm1Tmr/Rpe65^tm1Tmr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal eye physiology	J:51293, J:61889
	abnormal retina pigment epithelium morphology	J:130076
	abnormal retina rod cell outer segment morphology	J:51293
	abnormal rod electrophysiology	J:51293, J:71529, J:85796
	abnormal vitamin A metabolism	J:130076
	disorganized photoreceptor outer segment	J:130076
	photoreceptor outer segment degeneration	J:130076
	retina degeneration	J:51293
	retina outer nuclear layer degeneration	J:130076
	retina rod cell degeneration	J:81027
	short photoreceptor outer segment	J:130076
	thin retina outer nuclear layer	J:51293
Rpe65^tvrm148/Rpe65^tvrm148 C57BL/6J-Rpe65^tvrm148/J	abnormal cone electrophysiology	J:166679
	abnormal retina pigmentation	J:166679
	abnormal rod electrophysiology	J:166679
	retina photoreceptor degeneration	J:166679
	retina spots	J:166679
	short photoreceptor inner segment	J:166679
	short photoreceptor outer segment	J:166679

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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