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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rxra
retinoid X receptor alpha
MGI:98214
165 phenotypes from 11 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myl2tm1(cre)Krc/Myl2+
Rxratm1Krc/Rxratm1Krc
involves: 129S4/SvJae * Black Swiss 		no abnormal phenotype detected J:48085
Rxrapke/Rxrapke
C57BL/6J-Rxrapke 		abnormal dendritic cell physiology J:103186
abnormal regulatory T cell physiology J:103186
abnormal T-helper 2 cell morphology J:103186
alopecia J:103186
cornea opacity J:103186
dermal cyst J:103186
diluted coat color J:103186
kyphosis J:103186
Rxratm1.1Krc/Rxratm1.1Krc
involves: 129S4/SvJae * Black Swiss 		congestive heart failure J:48085
lethality throughout fetal growth and development, complete penetrance J:48085
Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal conotruncus septation J:146761
abnormal cornea stroma morphology J:146761
abnormal eyelid morphology J:146761
abnormal ocular fundus morphology J:146761
abnormal optic disk morphology J:146761
abnormal pharyngeal arch artery morphology J:146761
abnormal placenta labyrinth morphology J:146761
abnormal placenta morphology J:146761
absent Harderian gland J:146761
absent sclera J:146761
absent sublingual duct J:146761
decreased fetal size J:146761
decreased ventral retina size J:146761
lethality throughout fetal growth and development, incomplete penetrance J:146761
perinatal lethality, complete penetrance J:146761
persistent hyperplastic primary vitreous J:146761
ventral rotation of lens J:146761
ventricular myocardium compact layer hypoplasia J:146761
Rxratm1Ipc/Rxratm1Ipc
involves: 129S2/SvPas 		abnormal epidermis stratum corneum morphology J:109090
abnormal keratinocyte morphology J:109090
abnormal skin condition J:109090
abnormal skin morphology J:109090
lethality throughout fetal growth and development, complete penetrance J:60351
ventricular hypoplasia J:60351
Rxratm1Ipc/Rxratm1Ipc
Tg(Myh6-Rxra)41Pcn/0
involves: 129S2/SvPas 		lethality throughout fetal growth and development, complete penetrance J:60351
ventricular hypoplasia J:60351
Rxratm1Ipc/Rxratm2Ipc
involves: 129S2/SvPas * C57BL/6 		abnormal eye development J:146761
Rxratm1Krc/Rxra+
Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 		abnormal prostate gland branching morphogenesis J:78553
increased prostate intraepithelial neoplasia incidence J:78553
prostate gland epithelial hyperplasia J:78553
Rxratm1Krc/Rxratm1Krc
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal kidney morphology J:168799
abnormal macrophage activation involved in immune response J:168799
abnormal nephron morphology J:168799
abnormal peritoneal macrophage morphology J:168799
abnormal podocyte foot process morphology J:168799
abnormal renal glomerulus morphology J:168799
albuminuria J:168799
enlarged kidney J:168799
expanded mesangial matrix J:168799
fused podocyte foot processes J:168799
glomerulonephritis J:168799
impaired macrophage phagocytosis J:168799
increased anti-double stranded DNA antibody level J:168799
increased anti-nuclear antigen antibody level J:168799
increased anti-single stranded DNA antibody level J:168799
increased autoantibody level J:168799
increased circulating creatine level J:168799
increased IgG level J:168799
increased IgM level J:168799
increased kidney weight J:168799
increased mesangial cell number J:168799
increased renal glomerulus apoptosis J:168799
increased renal glomerulus basement membrane thickness J:168799
increased urine protein level J:168799
renal glomerulus hypertrophy J:168799
Rxratm1Krc/Rxratm1Krc
Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 		abnormal prostate gland branching morphogenesis J:78553
abnormal prostate gland physiology J:78553
increased prostate intraepithelial neoplasia incidence J:78553
Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6 		abnormal atrioventricular valve morphology J:35363
abnormal heart development J:35363
abnormal heart ventricle morphology J:35363
abnormal interventricular septum morphology J:35363
abnormal mitral valve morphology J:35363
abnormal myocardial trabeculae morphology J:35363
abnormal myocardium compact layer morphology J:35363
abnormal myocardium layer morphology J:35363
abnormal tricuspid valve morphology J:35363
abnormal ventricle papillary muscle morphology J:35363
decreased heart left ventricle wall thickness J:35363
decreased heart right ventricle wall thickness J:35363
double outlet right ventricle J:35363
mitral valve stenosis J:35363
pulmonary artery stenosis J:35363
thin ventricular wall J:35363
Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6 		abnormal atrioventricular cushion morphology J:35363
abnormal conotruncal ridge morphology J:35363
abnormal heart left atrium morphology J:65904
abnormal heart morphology J:65904
abnormal heart ventricle shape J:18047, J:65904
abnormal mitral valve morphology J:35363
abnormal myocardial trabeculae morphology J:35363
abnormal myocardium compact layer morphology J:18047
abnormal myocardium layer morphology J:18047, J:35363
abnormal pericardial cavity morphology J:18047
abnormal pericardium morphology J:18047
abnormal tricuspid valve morphology J:35363
abnormal truncus arteriosus septation J:18047
abnormal ventricle papillary muscle morphology J:35363
aortopulmonary window J:35363
atrioventricular block J:65904
complete atrioventricular septal defect J:35363
congestive heart failure J:18047, J:65904
decreased cardiac output J:65904
decreased heart left ventricle muscle contractility J:65904
decreased heart rate J:65904
decreased hepatocyte proliferation J:18047
delayed hepatic development J:18047
dilated heart right atrium J:18047
dilated heart right ventricle J:18047
double outlet right ventricle J:35363
failure of atrioventricular cushion closure J:35363
heart block J:65904
lethality throughout fetal growth and development, complete penetrance J:18047
mitral valve atresia J:18047
muscular ventricular septal defect J:18047, J:35363, J:65904
persistent truncus arteriosus J:35363
skin edema J:18047
small liver J:18047
thin ventricular wall J:18047, J:35363
trabecula carnea hypoplasia J:18047
translucent skin J:18047
ventricular hypoplasia J:18047
ventricular myocardium compact layer hypoplasia J:35363
Rxratm2Ipc/Rxra+
involves: 129 		abnormal postnatal growth/weight/body size J:20550
Rxratm2Ipc/Rxratm2Ipc
involves: 129 		abnormal cardiovascular system morphology J:20550
abnormal cricoid cartilage morphology J:42773
abnormal extraembryonic tissue morphology J:44230
abnormal eye morphology J:20550
prenatal lethality J:20550
Rxratm2Ipc/Rxratm4.1Ipc
involves: 129 		abnormal eye development J:67149
abnormal vasculogenesis J:67149
edema J:67149
lethality throughout fetal growth and development, complete penetrance J:67149
pallor J:67149
Rxratm2Ipc/Rxratm4Ipc
Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal hair cycle anagen phase J:67149
abnormal hair cycle telogen phase J:67149
abnormal hair follicle melanin granule distribution J:67149
abnormal hair follicle morphology J:67149
abnormal hair growth J:67149
abnormal Langerhans cell morphology J:67149
abnormal melanosome morphology J:67149
abnormal piliary canal morphology J:67149
abnormal skin morphology J:67149
alopecia J:67149
delayed hair appearance J:67149
dermal cyst J:67149
dilated piliary canal J:67149
diluted coat color J:67149
disorganized outer root sheath cells J:67149
distorted hair follicle pattern J:67149
hair follicle degeneration J:67149
hyperkeratosis J:67149
increased keratinocyte proliferation J:67149
scaly skin J:67149
skin inflammation J:67149
skin lesions J:67149
thick dermal layer J:67149
thick epidermis suprabasal layer J:67149
thin hypodermis J:67149
Rxratm3Ipc/Rxratm3Ipc
involves: 129 * C57BL/6 		abnormal axial skeleton morphology J:69853
abnormal cardiovascular system morphology J:69853
abnormal digit morphology J:69853
abnormal eye morphology J:69853
abnormal postnatal growth/weight/body size J:69853
abnormal skeleton development J:69853
normal behavior/neurological phenotype J:69853
postnatal lethality, incomplete penetrance J:69853
Rxratm4.1Ipc/Rxratm4.1Ipc
involves: 129S2/SvPas 		abnormal eye development J:67149
abnormal vasculogenesis J:67149
edema J:67149
lethality throughout fetal growth and development, complete penetrance J:67149
pallor J:67149
Rxratm4Ipc/Rxratm4Ipc
Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal epidermis stratum corneum morphology J:109090
abnormal keratinocyte morphology J:109090
shiny skin J:109090
Rxratm4Ipc/Rxratm4Ipc
Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas 		abnormal cone electrophysiology J:88451
abnormal photoreceptor outer segment morphology J:88451
abnormal retina outer nuclear layer morphology J:88451
abnormal retina pigment epithelium morphology J:88451
abnormal retina pigmentation J:88451
abnormal rod electrophysiology J:88451
decreased retina photoreceptor cell number J:88451
delayed dark adaptation J:88451
disorganized photoreceptor outer segment J:88451
retina pigment epithelium atrophy J:88451
short photoreceptor outer segment J:88451
Tg(Myh6-Rxra)41Pcn/0
Not Specified 		abnormal cardiac thrombosis J:60351
abnormal M line morphology J:60351
abnormal myocardial fiber morphology J:60351
abnormal respiratory electron transport chain J:60351
abnormal sarcomere morphology J:60351
abnormal Z line morphology J:60351
dilated cardiomyopathy J:60351
enlarged heart J:60351
myocardial fiber degeneration J:60351
pleural effusion J:60351
premature death J:60351
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory