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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Scn1a
sodium channel, voltage-gated, type I, alpha
MGI:98246
86 phenotypes from 11 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Emx1tm1.1(cre)Ito/Emx1+
Scn1atm2.1Kzy/Scn1atm2.1Kzy
involves: 129P2/OlaHsd * C57BL/6 		abnormal neocortex morphology J:202863
normal behavior/neurological phenotype J:202863
Emx1tm1.1(cre)Ito/Emx1+
Scn1atm2.1Kzy/Scn1atm2.1Kzy
Tg(Slc32a1-cre)65Kzy/0
involves: 129P2/OlaHsd * C57BL/6 		convulsive seizures J:202863
premature death J:202863
Scn1aem1Anord/Scn1a+
C57BL/6N-Scn1aem1Anord 		abnormal spike wave discharge J:333350
normal behavior/neurological phenotype J:333350
environmentally induced seizures J:333350
normal growth/size/body region phenotype J:333350
increased susceptibility to pharmacologically induced seizures J:333350
Scn1aem1Anord/Scn1aem1Anord
C57BL/6N-Scn1aem1Anord 		abnormal response to novel object J:333350
abnormal spatial working memory J:333350
normal behavior/neurological phenotype J:333350
decreased birth body size J:333350
environmentally induced seizures J:333350
hyperactivity J:333350
lethality throughout fetal growth and development, incomplete penetrance J:333350
normal muscle phenotype J:333350
neonatal lethality J:333350
postnatal growth retardation J:333350
preweaning lethality, incomplete penetrance J:333350
Scn1atm1.1Aesc/Scn1a+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J 		increased susceptibility to pharmacologically induced seizures J:170734
Scn1atm1.1Aesc/Scn1a+
involves: 129X1/SvJ * C57BL/6J * SJL 		abnormal GABA-mediated receptor currents J:161191
abnormal spike wave discharge J:161191
environmentally induced seizures J:161191
increased susceptibility to pharmacologically induced seizures J:161191
seizures J:161191
tonic seizures J:161191
tonic-clonic seizures J:161191
Scn1atm1.1Aesc/Scn1atm1.1Aesc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J 		postnatal lethality, complete penetrance J:170734
Scn1atm1.1Aesc/Scn1atm1.1Aesc
involves: 129X1/SvJ * C57BL/6J * SJL 		abnormal GABA-mediated receptor currents J:161191
clonic seizures J:161191
decreased body weight J:161191
environmentally induced seizures J:161191
impaired ability to fire action potentials J:161191
maximal tonic hindlimb extension seizures J:161191
normal nervous system phenotype J:161191
postnatal lethality, complete penetrance J:161191
seizures J:161191
tonic seizures J:161191
weight loss J:161191
Scn1atm1.1Kzy/Scn1a+
involves: 129P2/OlaHsd * C3HeB/FeJ 		apnea J:260796
decreased heart rate J:260796
environmentally induced seizures J:260796
increased susceptibility to induced morbidity/mortality J:260796
premature death J:260796
seizures J:260796
Scn1atm1.1Kzy/Scn1a+
involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J 		abnormal cardiovascular system physiology J:209093
abnormal heart electrocardiography waveform feature J:209093
abnormal myocardial fiber physiology J:209093
abnormal RR interval J:209093
bundle branch block J:209093
convulsive seizures J:209093
decreased heart rate J:209093
increased susceptibility to pharmacologically induced seizures J:209093
irregular heartbeat J:209093
premature death J:209093
prolonged QT interval J:209093
ventricular fibrillation J:209093
ventricular premature beat J:209093
Scn1atm1.1Kzy/Scn1a+
involves: 129P2/OlaHsd * C57BL/6 		premature death J:121969
seizures J:121969
Scn1atm1.1Swl/Scn1a+
involves: 129S1/Sv * 129S2/SvPasCrl * 129X1/SvJ 		premature death J:221045
Scn1atm1.1Swl/Scn1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6JNarl 		abnormal dendrite morphology J:221045
abnormal dendritic spine morphology J:221045
abnormal hippocampus granule cell morphology J:221045
abnormal miniature excitatory postsynaptic currents J:221045
abnormal miniature inhibitory postsynaptic currents J:221045
abnormal synaptic transmission J:221045
decreased paired-pulse ratio J:221045
environmentally induced seizures J:221045
premature death J:221045
tonic-clonic seizures J:221045
Scn1atm1.1Swl/Scn1atm1.1Swl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6JNarl 		abnormal gait J:221045
decreased body weight J:221045
postnatal lethality, complete penetrance J:221045
tonic-clonic seizures J:221045
Scn1atm1Kea/Scn1a+
129S6/SvEvTac-Scn1atm1Kea 		no abnormal phenotype detected J:203040
Scn1atm1Kea/Scn1a+
(C57BL/6J x 129S6/SvEvTac-Scn1atm1Kea)F1 		premature death J:203040
seizures J:203040
Scn1atm1Kzy/Scn1a+
involves: 129P2/OlaHsd * C57BL/6 		premature death J:121969
seizures J:121969
Scn1atm1Kzy/Scn1atm1Kzy
involves: 129P2/OlaHsd * C57BL/6 		abnormal gait J:121969
abnormal involuntary movement J:121969
decreased body weight J:121969
decreased brain size J:121969
decreased brain weight J:121969
jerky movement J:121969
postnatal lethality, complete penetrance J:121969
seizures J:121969
tonic seizures J:121969
tonic-clonic seizures J:121969
weight loss J:121969
Scn1atm1Wac/Scn1a+
129-Scn1atm1Wac 		premature death J:113149
Scn1atm1Wac/Scn1a+
B6.129-Scn1atm1Wac 		abnormal action potential J:113149
abnormal brain wave pattern J:113149
abnormal habituation to a novel odor J:188126
abnormal long-term spatial reference memory J:188126
abnormal nervous system electrophysiology J:113149
abnormal nest building behavior J:188126
abnormal olfactory behavior J:188126
abnormal response to novel odor J:188126
abnormal response to social novelty J:188126
abnormal social investigation J:188126
circling J:188126
head bobbing J:113149
impaired contextual conditioning behavior J:188126
impaired spatial learning J:188126
increased anxiety-related response J:188126
increased grooming behavior J:188126
increased locomotor activity J:188126
increased thigmotaxis J:188126
premature death J:113149
seizures J:113149
Scn1atm1Wac/Scn1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		premature death J:113149
reduced fertility J:113149
Scn1atm1Wac/Scn1a+
involves: 129S1/Sv * 129X1/SvJ * FVB/NJ 		abnormal spike wave discharge J:129998
increased susceptibility to pharmacologically induced seizures J:129998
premature death J:129998
tonic-clonic seizures J:129998
Scn1atm1Wac/Scn1a+
Tg(Scn1a*)RH9Aesc/0
involves: 129S1/Sv * 129X1/SvJ * FVB/NJ 		premature death J:150454
Scn1atm1Wac/Scn1atm1Wac
B6.129-Scn1atm1Wac 		abnormal action potential J:113149
abnormal nervous system electrophysiology J:113149
abnormal postural reflex J:113149
abnormal posture J:113149
akinesia J:113149
ataxia J:113149
clonic seizures J:113149
convulsive seizures J:113149
impaired righting response J:113149
postnatal lethality, complete penetrance J:113149
seizures J:113149
tremors J:113149
Scn1atm1Wac/Scn1atm1Wac
involves: 129S1/Sv * 129X1/SvJ * FVB/NJ 		postnatal lethality, complete penetrance J:129998
Scn1atm1Wac/Scn1atm1Wac
Tg(Scn1a*)RH9Aesc/0
involves: 129S1/Sv * 129X1/SvJ * FVB/NJ 		postnatal lethality J:150454
premature death J:150454
Scn1atm2.1Kzy/Scn1a+
Tg(Pvalb-cre)1Tama/0
involves: 129P2/OlaHsd * C57BL/6 * DBA 		convulsive seizures J:202863
postnatal lethality J:202863
Scn1atm2.1Kzy/Scn1a+
Tg(Slc32a1-cre)65Kzy/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal brain wave pattern J:202863
convulsive seizures J:202863
postnatal lethality J:202863
premature death J:202863
Scn1atm2.1Kzy/Scn1atm2.1Kzy
Tg(Pvalb-cre)1Tama/0
involves: 129P2/OlaHsd * C57BL/6 * DBA 		ataxia J:202863
convulsive seizures J:202863
premature death J:202863
Scn1atm2.1Kzy/Scn1atm2.1Kzy
Tg(Slc32a1-cre)65Kzy/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal cerebellar molecular layer J:202863
abnormal hippocampus neuron morphology J:202863
abnormal neocortex morphology J:202863
convulsive seizures J:202863
decreased locomotor activity J:202863
postnatal lethality, complete penetrance J:202863
Scn1atm2.1Wac/Scn1a+
Tg(I12b-cre)1Jlr/0
involves: 129X1/SvJ * C57BL/6J 		abnormal inhibitory postsynaptic currents J:188126
abnormal social investigation J:188126
circling J:188126
impaired contextual conditioning behavior J:188126
increased anxiety-related response J:188126
increased excitatory postsynaptic current frequency J:188126
increased locomotor activity J:188126
increased thigmotaxis J:188126
Scn1atm2.1Wac/Scn1a+
Tg(I12b-cre)1Jlr/0
involves: C57BL/6J * CD-1 		clonic seizures J:189897
environmentally induced seizures J:189897
postnatal lethality, incomplete penetrance J:189897
premature death J:189897
seizures J:189897
tonic-clonic seizures J:189897
Scn1atm2.2Kzy/Scn1a+
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		convulsive seizures J:202863
premature death J:202863
Scn1atm2.2Kzy/Scn1atm2.2Kzy
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		ataxia J:202863
convulsive seizures J:202863
postnatal lethality, complete penetrance J:202863
weight loss J:202863
Tg(Scn1a*)RH9Aesc/0
involves: FVB/NJ 		abnormal neuron physiology J:150454
increased susceptibility to pharmacologically induced seizures J:150454
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory