Scn2a Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Scn2a
sodium channel, voltage-gated, type II, alpha
MGI:98248

18 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Scn2a^em1Gsp/Scn2a⁺ involves: C57BL/6J * SJL/J	abnormal action potential	J:311772
	abnormal channel response	J:311772
	abnormal CNS synaptic transmission	J:311772
	abnormal response to social novelty	J:311772
	abnormal social investigation	J:311772
	decreased anxiety-related response	J:311772
	decreased excitatory postsynaptic current frequency	J:311772
	increased locomotor activity	J:311772
Scn2a^em1Gsp/Scn2a^em1Gsp involves: C57BL/6J * SJL/J	perinatal lethality, complete penetrance	J:311772
Scn2a^tm1Mml/Scn2a^tm1Mml involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal brainstem morphology	J:76457
	abnormal hemoglobin	J:76457
	abnormal nervous system electrophysiology	J:76457
	absent gastric milk in neonates	J:76457
	cyanosis	J:76457
	hypoxia	J:76457
	postnatal lethality, complete penetrance	J:76457
	respiratory distress	J:76457
	weight loss	J:76457

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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