Scn5a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Scn5a
sodium channel, voltage-gated, type V, alpha
MGI:98251

49 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Scn5a^em1Coop/Scn5a⁺ involves: FVB/NJ	abnormal impulse conducting system conduction	J:279087
	abnormal QT interval	J:279087
	abnormal sinoatrial node conduction	J:279087
	atrioventricular block	J:279087
	irregular heartbeat	J:279087
	prolonged QRS complex duration	J:279087
Scn5a^em1Coop/Scn5a^em1Coop involves: C57BL/6NJ * FVB/NJ	abnormal heart electrocardiography waveform feature	J:279087
Scn5a^em1Coop/Scn5a^em1Coop involves: FVB/NJ	abnormal heart electrocardiography waveform feature	J:279087
	abnormal impulse conducting system conduction	J:279087
	abnormal QT interval	J:279087
	abnormal sinoatrial node conduction	J:279087
	atrioventricular block	J:279087
	decreased heart rate	J:279087
	irregular heartbeat	J:279087
	prolonged PR interval	J:279087
	prolonged QRS complex duration	J:279087
	sinus bradycardia	J:279087
	ventricular tachycardia	J:279087
Scn5a^tm1.1Iba/Scn5a⁺ involves: 129 * C57BL/6	abnormal action potential	J:266290
	abnormal heart atrium morphology	J:266290
	abnormal heart echocardiography feature	J:266290
	abnormal heart morphology	J:266290
	abnormal myocardial fiber physiology	J:266290
	abnormal myocardial fiber sodium currents	J:266290
	atrioventricular block	J:266290
	cardiac fibrosis	J:266290
	congestive heart failure	J:266290
	decreased body weight	J:266290
	increased heart weight	J:266290
	increased lung weight	J:266290
	increased myocardial fiber size	J:266290
	irregular heartbeat	J:266290
	liver vascular congestion	J:266290
	premature death	J:266290
	prolonged QRS complex duration	J:266290
	prolonged QT interval	J:266290
	thick ventricular wall	J:266290
	ventricular fibrillation	J:266290
	ventricular premature beat	J:266290
	ventricular tachycardia	J:266290
Scn5a^tm1Agrc/Scn5a⁺ involves: 129	abnormal impulse conducting system conduction	J:109689
	cardiac fibrosis	J:109689
	decreased heart rate	J:109689
	prolonged P wave	J:109689
	prolonged PR interval	J:109689
	prolonged QRS complex duration	J:109689
	prolonged QT interval	J:109689
	ventricular tachycardia	J:166438
Scn5a^tm1Agrc/Scn5a⁺ involves: 129 * C57BL/6J	abnormal heart rate	J:76331
	abnormal impulse conducting system conduction	J:76331
	abnormal myocardial fiber physiology	J:76331
	prolonged P wave	J:76331
	prolonged PR interval	J:76331
	ventricular tachycardia	J:76331
Scn5a^tm1Agrc/Scn5a^tm1Agrc involves: 129 * C57BL/6J	abnormal cardiac muscle contractility	J:76331
	abnormal heart ventricle morphology	J:76331
	abnormal trabecula carnea morphology	J:76331
	decreased embryo size	J:76331
	decreased myocardial fiber number	J:76331
	embryonic lethality during organogenesis, complete penetrance	J:76331
Scn5a^tm1Care/Scn5a⁺ FVB.129P2-Scn5a^tm1Care/Care	abnormal impulse conducting system conduction	J:128657
	abnormal myocardial fiber physiology	J:128657
	abnormal sinoatrial node conduction	J:128657
	decreased heart rate	J:128657
	normal mortality/aging	J:128657
	prolonged PQ interval	J:128657
	prolonged QRS complex duration	J:128657
	prolonged QT interval	J:128657
Scn5a^tm1Care/Scn5a^tm1Care FVB.129P2-Scn5a^tm1Care/Care	prenatal lethality, complete penetrance	J:128657
Scn5a^tm1Clhh/Scn5a⁺ involves: 129 * 129S/SvEv * C57BL/6J	abnormal impulse conducting system conduction	J:127879
	abnormal myocardial fiber physiology	J:127879
	increased susceptibility to induced morbidity/mortality	J:127879
	irregular heartbeat	J:127879
	postnatal lethality, incomplete penetrance	J:127879
	seizures	J:127879
	ventricular tachycardia	J:127879
Scn5a^tm1Clhh/Scn5a⁺ involves: 129/SvEv	abnormal atrioventricular node conduction	J:186583
	abnormal impulse conducting system conduction	J:186583
	abnormal sinoatrial node conduction	J:186583
	atrioventricular block	J:186583
	prolonged PR interval	J:186583
	prolonged QRS complex duration	J:186583
	prolonged QT interval	J:186583
	sinus bradycardia	J:186583
Scn5a^tm1Clhh/Scn5a^tm1Clhh involves: 129 * 129S/SvEv * C57BL/6J	decreased embryo size	J:127879
	embryo tissue necrosis	J:127879
	irregular heartbeat	J:127879
	prenatal lethality, complete penetrance	J:127879
Scn5a^tm1Pec/Scn5a⁺ involves: Swiss	abnormal impulse conducting system conduction	J:71542
	abnormal T wave	J:71542
	decreased heart rate	J:71542
	irregular heartbeat	J:71542
	premature death	J:71542
	prolonged QT interval	J:71542
Scn5a^tm1Pec/Scn5a^tm1Pec involves: Swiss	abnormal cardiovascular system physiology	J:71542
Scn5a^tm1Pec/Scn5a^tm1Pec involves: Swiss	embryonic lethality during organogenesis, complete penetrance	J:71542
Scn5a^tm2.1Care/Scn5a^tm2.1Care B6J.129P2(Cg)-Scn5a^tm2.1Care	abnormal atrioventricular bundle conduction	J:224433
	abnormal impulse conducting system conduction	J:224433
	abnormal myocardial fiber physiology	J:224433
	normal cardiovascular system phenotype	J:224433
	normal mortality/aging	J:224433
	prolonged P wave	J:224433
	prolonged PR interval	J:224433
	prolonged QRS complex duration	J:224433

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