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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ccl2
C-C motif chemokine ligand 2
MGI:98259
102 phenotypes from 7 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:171379
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * DBA 		normal immune system phenotype J:171379
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal leukocyte migration J:171379
increased susceptibility to bacterial infection J:171379
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 		abnormal leukocyte migration J:171379
increased susceptibility to bacterial infection J:171379
Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
involves: 129S1/Sv 		abnormal dendritic cell chemotaxis J:199611
abnormal dendritic cell physiology J:199611
decreased dendritic cell number J:199611
Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
involves: 129S1/Sv * C57BL/6 		abnormal chemokine level J:151874
abnormal chemokine secretion J:151874
abnormal neutrophil physiology J:151874
impaired macrophage chemotaxis J:151874
Ccl2tm1.2Tyos/Ccl2tm1.2Tyos
B6N.129S1(FVB)-Ccl2tm1.2Tyos/J 		no abnormal phenotype detected J:137887
Ccl2tm1Lex/Ccl2tm1Lex
involves: 129S5/SvEvBrd * C57BL/6 		normal impaired macrophage chemotaxis J:191510
Ccl2tm1Rol/Ccl2tm1Rol
(129S4/SvJae x C57BL/6)F1 		abnormal response to injury J:119615
decreased macrophage cell number J:119615
Ccl2tm1Rol/Ccl2tm1Rol
B6.129S4-Ccl2tm1Rol 		abnormal blood circulation J:118606
abnormal Bruch membrane morphology J:147328
abnormal chemokine level J:118606, J:151874
abnormal chemokine secretion J:151874
abnormal choriocapillaris morphology J:147328
abnormal conditioned taste aversion behavior J:102583
abnormal cytokine secretion J:68145
abnormal macrophage chemotaxis J:109290
abnormal neutrophil physiology J:151874
abnormal optic choroid morphology J:147328
abnormal response to injury J:118606
abnormal retina pigment epithelium morphology J:147328
abnormal skeletal muscle morphology J:118606
alcohol aversion J:102583
alcohol preference J:102583
choroidal neovascularization J:147328
decreased alcohol consumption J:102583
decreased interferon-gamma secretion J:68145
decreased leukocyte cell number J:68145
decreased macrophage cell number J:147328
decreased physiological sensitivity to xenobiotic J:110695
decreased susceptibility to experimental autoimmune encephalomyelitis J:68145
impaired macrophage chemotaxis J:68145, J:118606, J:151874
impaired righting response J:102583
impaired skeletal muscle regeneration J:118606
increased alcohol consumption J:102583
increased CD4-positive, alpha-beta T cell number J:68145
increased fluid intake J:102583
increased IgG1 level J:68145
increased IgG level J:147328
increased interleukin-10 secretion J:68145
increased muscle weight J:118606
increased neutrophil cell number J:118606
increased osteoclast cell number J:109290
increased susceptibility to age-related retinal degeneration J:147328
lipofuscinosis J:147328
premature tooth eruption J:109290
retina deposits J:147328
retina outer nuclear layer degeneration J:147328
retina photoreceptor degeneration J:147328
skeletal muscle necrosis J:118606
Ccl2tm1Rol/Ccl2tm1Rol
B6.129S4-Ccl2tm1Rol/J 		abnormal action potential J:326871
abnormal epididymal fat pad morphology J:110277
abnormal gluconeogenesis J:110277
abnormal glucose homeostasis J:126512
abnormal gonadal fat pad morphology J:126512
abnormal microglial cell physiology J:141739
abnormal neuron physiology J:326871
abnormal touch/ nociception J:326871
decreased adiponectin level J:126512
decreased body weight J:126512
decreased circulating free fatty acids level J:110277
decreased circulating insulin level J:110277
decreased fat cell size J:110277
decreased susceptibility to diet-induced hepatic steatosis J:110277
decreased susceptibility to neuronal excitotoxicity J:141739
impaired glucose tolerance J:126512
improved glucose tolerance J:110277
increased adiponectin level J:110277
increased circulating glucose level J:126512
increased circulating insulin level J:126512
increased circulating leptin level J:126512
increased insulin sensitivity J:110277
increased percent body fat/body weight J:126512
increased susceptibility to diet-induced obesity J:126512
increased total fat pad weight J:126512
Ccl2tm1Rol/Ccl2tm1Rol
involves: 129S4/SvJae 		abnormal macrophage physiology J:155025
abnormal monocyte morphology J:121281
abnormal posture J:155025
decreased inflammatory response J:155025
decreased lymphocyte cell number J:147697
decreased macrophage cell number J:147697
decreased physiological sensitivity to xenobiotic J:147697
impaired macrophage chemotaxis J:147697
increased circulating interferon-gamma level J:155025
increased circulating interleukin-10 level J:155025
increased circulating tumor necrosis factor level J:155025
increased susceptibility to infection induced morbidity/mortality J:155025
increased susceptibility to parasitic infection J:155025
increased vasodilation J:155025
Ccl2tm1Rol/Ccl2tm1Rol
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal monocyte morphology J:45920
decreased interferon-gamma secretion J:45920
decreased interleukin-4 secretion J:45920
decreased interleukin-5 secretion J:45920
decreased susceptibility to type IV hypersensitivity reaction J:45920
impaired macrophage chemotaxis J:45920
Ccl2tm1Rol/Ccl2tm1Rol
involves: 129S4/SvJae * C57BL/6 		abnormal heart left ventricle morphology J:108533
abnormal macrophage chemotaxis J:116878
abnormal physiological neovascularization J:107646
abnormal response to cardiac infarction J:108533
abnormal T cell physiology J:116878
decreased incidence of tumors by chemical induction J:56068
decreased interferon-gamma secretion J:116878
decreased interleukin-1 beta secretion J:116878
decreased interleukin-12b secretion J:116878
decreased susceptibility to induced colitis J:116878
decreased susceptibility to xenobiotic induced morbidity/mortality J:116878
impaired macrophage chemotaxis J:108533
Ccl2tm1Rol/Ccl2tm1Rol
involves: 129S4/SvJae * C57BL/6 * SJL 		decreased angiogenesis J:70862
delayed wound healing J:70862
Ccl2tm1Rol/Ccl2tm1Rol
SJL.129S4-Ccl2tm1Rol 		decreased susceptibility to experimental autoimmune encephalomyelitis J:68145
Ccl2tm1Rol/Ccl2tm1Rol
Tg(Ccr2-EGFP)8Pame/0
involves: 129S4/SvJae * C57BL/6J 		abnormal leukocyte migration J:171379
Ccl2tm1Tyos/Ccl2tm1Tyos
involves: 129S1/Sv * C57BL/6 		abnormal chemokine level J:151874
abnormal chemokine secretion J:151874
Tg(Fabp4-Ccl2)BYt/0
involves: C57BL/6N 		abnormal epididymal fat pad morphology J:110277
abnormal gluconeogenesis J:110277
abnormal glucose homeostasis J:110277
impaired glucose tolerance J:110277
increased circulating free fatty acids level J:110277
increased circulating glucose level J:110277
increased liver triglyceride level J:110277
insulin resistance J:110277
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory