About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ccl2
C-C motif chemokine ligand 2
MGI:98259
102 phenotypes from 7 alleles in 18 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:171379
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * DBA 		normal immune system phenotype J:171379
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal leukocyte migration J:171379
increased susceptibility to bacterial infection J:171379
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 		abnormal leukocyte migration J:171379
increased susceptibility to bacterial infection J:171379
Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
involves: 129S1/Sv 		abnormal dendritic cell chemotaxis J:199611
abnormal dendritic cell physiology J:199611
decreased dendritic cell number J:199611
Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
involves: 129S1/Sv * C57BL/6 		abnormal chemokine level J:151874
abnormal chemokine secretion J:151874
abnormal neutrophil physiology J:151874
impaired macrophage chemotaxis J:151874
Ccl2tm1.2Tyos/Ccl2tm1.2Tyos
B6N.129S1(FVB)-Ccl2tm1.2Tyos/J 		no abnormal phenotype detected J:137887
Ccl2tm1Lex/Ccl2tm1Lex
involves: 129S5/SvEvBrd * C57BL/6 		normal impaired macrophage chemotaxis J:191510
Ccl2tm1Rol/Ccl2tm1Rol
(129S4/SvJae x C57BL/6)F1 		abnormal response to injury J:119615
decreased macrophage cell number J:119615
Ccl2tm1Rol/Ccl2tm1Rol
B6.129S4-Ccl2tm1Rol 		abnormal blood circulation J:118606
abnormal Bruch membrane morphology J:147328
abnormal chemokine level J:118606, J:151874
abnormal chemokine secretion J:151874
abnormal choriocapillaris morphology J:147328
abnormal conditioned taste aversion behavior J:102583
abnormal cytokine secretion J:68145
abnormal macrophage chemotaxis J:109290
abnormal neutrophil physiology J:151874
abnormal optic choroid morphology J:147328
abnormal response to injury J:118606
abnormal retina pigment epithelium morphology J:147328
abnormal skeletal muscle morphology J:118606
alcohol aversion J:102583
alcohol preference J:102583
choroidal neovascularization J:147328
decreased alcohol consumption J:102583
decreased interferon-gamma secretion J:68145
decreased leukocyte cell number J:68145
decreased macrophage cell number J:147328
decreased physiological sensitivity to xenobiotic J:110695
decreased susceptibility to experimental autoimmune encephalomyelitis J:68145
impaired macrophage chemotaxis J:68145, J:118606, J:151874
impaired righting response J:102583
impaired skeletal muscle regeneration J:118606
increased alcohol consumption J:102583
increased CD4-positive, alpha-beta T cell number J:68145
increased fluid intake J:102583
increased IgG1 level J:68145
increased IgG level J:147328
increased interleukin-10 secretion J:68145
increased muscle weight J:118606
increased neutrophil cell number J:118606
increased osteoclast cell number J:109290
increased susceptibility to age-related retinal degeneration J:147328
lipofuscinosis J:147328
premature tooth eruption J:109290
retina deposits J:147328
retina outer nuclear layer degeneration J:147328
retina photoreceptor degeneration J:147328
skeletal muscle necrosis J:118606
Ccl2tm1Rol/Ccl2tm1Rol
B6.129S4-Ccl2tm1Rol/J 		abnormal action potential J:326871
abnormal epididymal fat pad morphology J:110277
abnormal gluconeogenesis J:110277
abnormal glucose homeostasis J:126512
abnormal gonadal fat pad morphology J:126512
abnormal microglial cell physiology J:141739
abnormal neuron physiology J:326871
abnormal touch/ nociception J:326871
decreased adiponectin level J:126512
decreased body weight J:126512
decreased circulating free fatty acids level J:110277
decreased circulating insulin level J:110277
decreased fat cell size J:110277
decreased susceptibility to diet-induced hepatic steatosis J:110277
decreased susceptibility to neuronal excitotoxicity J:141739
impaired glucose tolerance J:126512
improved glucose tolerance J:110277
increased adiponectin level J:110277
increased circulating glucose level J:126512
increased circulating insulin level J:126512
increased circulating leptin level J:126512
increased insulin sensitivity J:110277
increased percent body fat/body weight J:126512
increased susceptibility to diet-induced obesity J:126512
increased total fat pad weight J:126512
Ccl2tm1Rol/Ccl2tm1Rol
involves: 129S4/SvJae 		abnormal macrophage physiology J:155025
abnormal monocyte morphology J:121281
abnormal posture J:155025
decreased inflammatory response J:155025
decreased lymphocyte cell number J:147697
decreased macrophage cell number J:147697
decreased physiological sensitivity to xenobiotic J:147697
impaired macrophage chemotaxis J:147697
increased circulating interferon-gamma level J:155025
increased circulating interleukin-10 level J:155025
increased circulating tumor necrosis factor level J:155025
increased susceptibility to infection induced morbidity/mortality J:155025
increased susceptibility to parasitic infection J:155025
increased vasodilation J:155025
Ccl2tm1Rol/Ccl2tm1Rol
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal monocyte morphology J:45920
decreased interferon-gamma secretion J:45920
decreased interleukin-4 secretion J:45920
decreased interleukin-5 secretion J:45920
decreased susceptibility to type IV hypersensitivity reaction J:45920
impaired macrophage chemotaxis J:45920
Ccl2tm1Rol/Ccl2tm1Rol
involves: 129S4/SvJae * C57BL/6 		abnormal heart left ventricle morphology J:108533
abnormal macrophage chemotaxis J:116878
abnormal physiological neovascularization J:107646
abnormal response to cardiac infarction J:108533
abnormal T cell physiology J:116878
decreased incidence of tumors by chemical induction J:56068
decreased interferon-gamma secretion J:116878
decreased interleukin-1 beta secretion J:116878
decreased interleukin-12b secretion J:116878
decreased susceptibility to induced colitis J:116878
decreased susceptibility to xenobiotic induced morbidity/mortality J:116878
impaired macrophage chemotaxis J:108533
Ccl2tm1Rol/Ccl2tm1Rol
involves: 129S4/SvJae * C57BL/6 * SJL 		decreased angiogenesis J:70862
delayed wound healing J:70862
Ccl2tm1Rol/Ccl2tm1Rol
SJL.129S4-Ccl2tm1Rol 		decreased susceptibility to experimental autoimmune encephalomyelitis J:68145
Ccl2tm1Rol/Ccl2tm1Rol
Tg(Ccr2-EGFP)8Pame/0
involves: 129S4/SvJae * C57BL/6J 		abnormal leukocyte migration J:171379
Ccl2tm1Tyos/Ccl2tm1Tyos
involves: 129S1/Sv * C57BL/6 		abnormal chemokine level J:151874
abnormal chemokine secretion J:151874
Tg(Fabp4-Ccl2)BYt/0
involves: C57BL/6N 		abnormal epididymal fat pad morphology J:110277
abnormal gluconeogenesis J:110277
abnormal glucose homeostasis J:110277
impaired glucose tolerance J:110277
increased circulating free fatty acids level J:110277
increased circulating glucose level J:110277
increased liver triglyceride level J:110277
insulin resistance J:110277
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory