Ccl2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ccl2
C-C motif chemokine ligand 2
MGI:98259

35 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ccl2^tm1Rol/Ccl2⁺ Mpz^tm1Msch/Mpz⁺ involves: 129S4/SvJae * 129S7/SvEvBrd	abnormal macrophage derived foam cell morphology	J:133028
	decreased macrophage cell number	J:133028
	demyelination	J:133028
	neuron degeneration	J:133028
Ccl2^tm1Rol/Ccl2⁺ Tg(PMP22)C61Clh/0 involves: 129S4/SvJae * C57BL/6J * CBA/Ca	decreased grip strength	J:158350
	demyelination	J:158350
	increased macrophage cell number	J:158350
Ccl2^tm1Rol/Ccl2^tm1Rol Ccr2^tm1Mae/Ccr2^tm1Mae B6.129-Ccr2^tm1Mae Ccl2^tm1Rol	alcohol aversion	J:102583
	alcohol preference	J:102583
	decreased alcohol consumption	J:102583
Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J	abnormal amacrine cell morphology	J:200877
	abnormal Bruch membrane morphology	J:200877
	abnormal macrophage physiology	J:200877
	abnormal microglial cell morphology	J:200877
	abnormal Muller cell morphology	J:200877
	abnormal photoreceptor inner segment morphology	J:200877
	abnormal retina morphology	J:200877
	abnormal retina pigmentation	J:200877
	disorganized photoreceptor outer segment	J:200877
	increased microglial cell activation	J:200877
	increased susceptibility to age-related retinal degeneration	J:200877
	retina photoreceptor degeneration	J:200877
	retina pigment epithelium atrophy	J:200877
Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Zm/Cx3cr1^tm1Zm involves: 129 * 129S4/SvJae	abnormal Bruch membrane morphology	J:126935
	abnormal retina morphology	J:126935
	abnormal retina pigment epithelium morphology	J:126935
	abnormal retina pigmentation	J:126935
	choroidal neovascularization	J:126935
	decreased litter size	J:126935
	disorganized photoreceptor outer segment	J:126935
	retina deposits	J:126935
	retina photoreceptor degeneration	J:126935
	retina pigment epithelium atrophy	J:126935
	retina pigment epithelium hyperplasia	J:126935
	variable depigmentation	J:126935
Ccl2^tm1Rol/Ccl2^tm1Rol Ldlr^tm1Her/Ldlr^tm1Her involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	decreased susceptibility to atherosclerosis	J:75837
	increased circulating triglyceride level	J:75837
	increased circulating VLDL cholesterol level	J:75837
Ccl2^tm1Rol/Ccl2^tm1Rol Mpz^tm1Msch/Mpz⁺ involves: 129S4/SvJae * 129S7/SvEvBrd	abnormal cytokine level	J:133028
	decreased macrophage cell number	J:133028
	demyelination	J:133028
	increased macrophage cell number	J:133028
	neuron degeneration	J:133028
Ccl2^tm1Rol/Ccl2^tm1Rol Tg(PMP22)C61Clh/0 involves: 129S4/SvJae * C57BL/6J * CBA/Ca	abnormal action potential	J:158350
	abnormal grip strength	J:158350
	decreased nerve conduction velocity	J:158350
	demyelination	J:158350
	increased macrophage cell number	J:158350

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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