Selp Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Selp
selectin, platelet
MGI:98280

75 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fas^lpr/Fas^lpr Selp^tm1Bay/Selp^tm1Bay MRL.Cg-Selp^tm1Bay Fas^lpr	abnormal chemokine secretion	J:127199
	abnormal glomerular capillary endothelium morphology	J:127199
	abnormal leukocyte adhesion	J:126009
	abnormal renal glomerular capsule morphology	J:127199
	abnormal renal glomerulus morphology	J:127199
	dermatitis	J:127199
	expanded mesangial matrix	J:127199
	fused podocyte foot processes	J:127199
	glomerular crescent	J:127199
	glomerulonephritis	J:127199
	impaired leukocyte tethering or rolling	J:126009
	increased mesangial cell number	J:127199
	increased neutrophil cell number	J:127199
	kidney failure	J:127199
	podocyte foot process effacement	J:127199
	premature death	J:127199
	renal glomerular synechia	J:127199
	renal glomerulus fibrosis	J:127199
	renal necrosis	J:127199
	renal tubule atrophy	J:127199
	vascular inflammation	J:127199
Icam1^tm1Bay/Icam1^tm1Bay Sele^tm2Alb/Sele^tm2Alb Selp^tm1Bay/Selp^tm1Bay involves: 129S7/SvEvBrd * C57BL/6	decreased acute inflammation	J:112286
	impaired neutrophil chemotaxis	J:112286
	increased neutrophil cell number	J:112286
	normal integument phenotype	J:112286
	skin edema	J:112286
Icam1^tm1Bay/Icam1^tm1Bay Selp^tm1Bay/Selp^tm1Bay B6.129S7-Icam1^tm1Bay Selp^tm1Bay/J	edema	J:119906
	normal immune system phenotype	J:119906
	normal nervous system phenotype	J:119906
Icam1^tm1Bay/Icam1^tm1Bay Selp^tm1Bay/Selp^tm1Bay either: B6.129S7-Selp^tm1Bay Icam1^tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)	impaired leukocyte tethering or rolling	J:31374
Icam1^tm1Bay/Icam1^tm1Bay Selp^tm1Bay/Selp^tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal leukocyte migration	J:24239
	increased neutrophil cell number	J:24239
Sele^tm1Hyn/Sele^tm1Hyn Sell^tm1Hyn/Sell^tm1Hyn Selp^tm1Hyn/Selp^tm1Hyn involves: 129S2/SvPas * C57BL/6	impaired eosinophil recruitment	J:57973
	impaired leukocyte tethering or rolling	J:57973
	impaired neutrophil recruitment	J:57973
	increased eosinophil cell number	J:57973
	increased leukocyte cell number	J:57973
	increased monocyte cell number	J:57973
	increased neutrophil cell number	J:57973
Sele^tm1Hyn/Sele^tm1Hyn Selp^tm1Hyn/Selp^tm1Hyn involves: 129S2/SvPas	abnormal common myeloid progenitor cell morphology	J:31626
	abnormal cytokine level	J:31626
	abnormal definitive hematopoiesis	J:31626
	abnormal erythropoiesis	J:31626
	abnormal granulocyte differentiation	J:31626
	abnormal myelopoiesis	J:31626
	extramedullary hematopoiesis	J:31626
	impaired hematopoiesis	J:31626
	impaired leukocyte tethering or rolling	J:31626
	impaired neutrophil recruitment	J:31626
	increased circulating interleukin-3 level	J:31626
	increased eosinophil cell number	J:31626
	increased erythroid progenitor cell number	J:31626
	increased leukocyte cell number	J:31626
	increased lymphocyte cell number	J:31626
	increased monocyte cell number	J:31626
	increased neutrophil cell number	J:31626
	increased spleen red pulp amount	J:31626
	increased spleen weight	J:31626
	increased susceptibility to bacterial infection	J:31626
	premature death	J:31626
	spleen hyperplasia	J:31626
Sele^tm1Hyn/Sele^tm1Hyn Selp^tm1Hyn/Selp^tm1Hyn involves: 129S2/SvPas * C57BL/6	impaired eosinophil recruitment	J:57973
	impaired leukocyte tethering or rolling	J:57973
	impaired neutrophil recruitment	J:57973
	increased eosinophil cell number	J:57973
	increased leukocyte cell number	J:57973
	increased monocyte cell number	J:57973
	increased neutrophil cell number	J:57973
Sele^tm2Alb/Sele^tm2Alb Sell^tm2Alb/Sell^tm2Alb Selp^tm1Bay/Selp^tm1Bay involves: 129S7/SvEvBrd * C57BL/6	abnormal cellular extravasation	J:70682
	abnormal cervical lymph node morphology	J:70682
	abnormal liver physiology	J:106550
	abnormal lung morphology	J:70682
	abnormal lung vasculature morphology	J:70682
	abnormal spleen B cell follicle morphology	J:70682
	abnormal spleen B cell follicle shape	J:106550
	abnormal spleen morphology	J:70682
	decreased circulating alanine transaminase level	J:106550
	decreased spleen B cell follicle number	J:106550
	enlarged lymph nodes	J:70682
	extramedullary hematopoiesis	J:70682
	hepatic necrosis	J:106550
	normal immune system phenotype	J:70682
	impaired leukocyte tethering or rolling	J:70682
	increased eosinophil cell number	J:70682
	increased leukocyte cell number	J:70682
	increased monocyte cell number	J:70682
	increased neutrophil cell number	J:70682, J:106550
	normal integument phenotype	J:70682
	lung inflammation	J:70682
Sele^tm2Alb/Sele^tm2Alb Selp^tm1Bay/Selp^tm1Bay involves: 129S7/SvEvBrd * C57BL/6	abnormal cytokine secretion	J:70682
	abnormal lung morphology	J:70682
	abnormal lung vasculature morphology	J:70682
	abnormal lymph node germinal center morphology	J:70682
	abnormal lymph node secondary follicle morphology	J:70682
	abnormal neutrophil physiology	J:112286
	abnormal spleen B cell follicle morphology	J:70682
	decreased acute inflammation	J:112286
	decreased spleen B cell follicle number	J:70682
	enlarged lymph nodes	J:70682
	extramedullary hematopoiesis	J:70682
	impaired leukocyte tethering or rolling	J:70682
	increased eosinophil cell number	J:70682
	increased leukocyte cell number	J:70682
	increased monocyte cell number	J:70682
	increased neutrophil cell number	J:70682, J:112286
	spontaneous skin ulceration	J:70682, J:112286
Sele^tm2Alb/Sele^tm2Alb Selp^tm1Bay/Selp^tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal leukocyte cell number	J:101979
	abnormal pilomotor reflex	J:101979
	decreased locomotor activity	J:101979
	eye inflammation	J:101979
	head tilt	J:101979
	increased neutrophil cell number	J:101979
	increased susceptibility to bacterial infection	J:101979
	spinning	J:101979
	tremors	J:101979
	weight loss	J:101979
Sell^tm3Hyn/Sell^tm3Hyn Selp^tm1Hyn/Selp^tm1Hyn involves: 129S2/SvPas * C57BL/6	impaired eosinophil recruitment	J:57973
	impaired leukocyte tethering or rolling	J:57973
	impaired neutrophil recruitment	J:57973
	increased eosinophil cell number	J:57973
	increased leukocyte cell number	J:57973
	increased neutrophil cell number	J:57973
Sell^tm4Hyn/Sell^tm4Hyn Selp^tm1Hyn/Selp^tm1Hyn involves: 129S2/SvPas * C57BL/6	impaired leukocyte tethering or rolling	J:57973
	impaired neutrophil recruitment	J:57973
	increased eosinophil cell number	J:57973

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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