Spi1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spi1
Spi-1 proto-oncogene
MGI:98282

97 phenotypes from 17 alleles in 21 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Spi1^tm2Dgt/Spi1^tm2Dgt involves: 129P2/OlaHsd * C57BL/6	normal hematopoietic system phenotype	J:114150
Spi1^tm1.1Dgt/Spi1^tm1.1Dgt involves: 129S1/Sv * 129X1/SvJ	abnormal bone marrow morphology	J:90331
	abnormal definitive hematopoiesis	J:90331
	abnormal erythrocyte cell number	J:90331
	abnormal spleen morphology	J:90331
	decreased B cell number	J:90331
	enlarged liver	J:90331
	enlarged spleen	J:90331
	increased leukemia incidence	J:90331
	increased T cell derived lymphoma incidence	J:90331
	increased tumor incidence	J:90331
	premature death	J:90331
	spleen hyperplasia	J:90331
Spi1^tm1.1Nutt/Spi1^tm1.1Nutt involves: C57BL/6 * BALB/cJ	absent common myeloid progenitor cells	J:98188
Spi1^tm1.1Rpd/Spi1^tm1.1Rpd involves: 129/Sv * Black Swiss * FVB/N	abnormal common myeloid progenitor cell morphology	J:138501
	postnatal lethality, complete penetrance	J:138501
Spi1^tm1.2Dgt/Spi1^tm1.2Dgt involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:106788
Spi1^tm1.2Nutt/Spi1^tm1.2Nutt Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal bone marrow cell morphology/development	J:98188
	abnormal granulocyte differentiation	J:98188
	abnormal spleen morphology	J:98188
	absent common myeloid progenitor cells	J:98188
	absent erythrocytes	J:98188
	decreased B cell number	J:98188
	extramedullary hematopoiesis	J:98188
	increased granulocyte number	J:98188
Spi1^tm1.3Dgt/Spi1^tm1.3Dgt involves: 129 * BALB/c * C57BL/6	abnormal chromosome number	J:90331
	abnormal definitive hematopoiesis	J:90331
	abnormal liver morphology	J:90331
	abnormal proerythroblast morphology	J:90331
	abnormal spleen morphology	J:90331
	decreased B cell number	J:90331
	enlarged spleen	J:90331
	increased leukemia incidence	J:90331
	increased liver weight	J:90331
	increased neutrophil cell number	J:90331
	increased spleen weight	J:90331
	increased T cell derived lymphoma incidence	J:90331
	liver hyperplasia	J:90331
	premature death	J:90331
	spleen hyperplasia	J:90331
Spi1^tm1.3Dgt/Spi1^tm1.3Dgt involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	abnormal double-negative T cell morphology	J:106040
	abnormal T cell subpopulation ratio	J:106040
	arrested B cell differentiation	J:106040
	decreased B-1a cell number	J:106040
	decreased granulocyte number	J:106040
	decreased mature B cell number	J:106040
	decreased pre-B cell number	J:106040
	decreased pro-B cell number	J:106040
	decreased T cell number	J:106040
	decreased thymocyte number	J:106040
	increased B-1 B cell number	J:106040
	increased B-1b cell number	J:106040
	increased IgM level	J:106040
	increased leukemia incidence	J:106040
	increased lymphocyte cell number	J:106040
	increased T cell derived lymphoma incidence	J:106040
	increased T cell number	J:106040
	premature death	J:106040
	small thymus	J:106040
Spi1^tm1.3Nutt/Spi1^tm1.3Nutt C57BL/6-Sfpi1^tm1.3Nutt	absent common myeloid progenitor cells	J:98188
Spi1^tm1.3Nutt/Spi1^tm1.3Nutt C57BL/6-Sfpi1^tm1.3Nutt	neonatal lethality, complete penetrance	J:98188
Spi1^tm1Kast/Spi1⁺ B6.129S2-Spi1^tm1Kast	abnormal erythropoiesis	J:90543
	increased bone marrow cell number	J:196609
	increased hematopoietic stem cell number	J:196609
Spi1^tm1Kast/Spi1^tm1Kast B6.129S2-Spi1^tm1Kast	abnormal erythropoiesis	J:90543
	abnormal fetal derived definitive erythrocyte cell number	J:90543
	absent B cells	J:90543
	failure of myelopoiesis	J:90543
	neonatal lethality, complete penetrance	J:90543
Spi1^tm1Nutt/Spi1^tm1Nutt involves: C57BL/6	no abnormal phenotype detected	J:95651
Spi1^tm1Ram/Spi1⁺ involves: 129S2/SvPas	abnormal eye development	J:101493
Spi1^tm1Ram/Spi1⁺ involves: 129S2/SvPas	persistence of hyaloid vascular system	J:101493
Spi1^tm1Ram/Spi1^tm1Ram involves: 129S2/SvPas	abnormal eye development	J:101493
	decreased macrophage cell number	J:101493
	normal homeostasis/metabolism phenotype	J:95801
	persistence of hyaloid vascular system	J:101493
Spi1^tm1Ram/Spi1^tm1Ram involves: 129S2/SvPas * C57BL/6	abnormal astrocyte morphology	J:116087
	abnormal B cell number	J:36473
	abnormal liver morphology	J:36473
	abnormal macrophage differentiation	J:36473
	abnormal microglial cell morphology	J:116087
	abnormal neutrophil differentiation	J:36473
	abnormal T cell differentiation	J:36473
	abnormal T cell number	J:36473
	absent mature B cells	J:36473
	decreased CD4-positive, alpha-beta T cell number	J:36473
	decreased CD8-positive, alpha-beta T cell number	J:36473
	decreased double-positive T cell number	J:36473
	decreased macrophage cell number	J:36473
	decreased neutrophil cell number	J:36473
	decreased spleen red pulp amount	J:36473
	decreased thymocyte number	J:36473
	neonatal lethality, complete penetrance	J:36473
	postnatal growth retardation	J:116087
	premature death	J:116087
	sepsis	J:36473
Spi1^tm1Rpd/Spi1^tm1Rpd involves: 129	abnormal common myeloid progenitor cell morphology	J:138501
Spi1^tm1Rpd/Spi1^tm1Rpd involves: 129	postnatal lethality, incomplete penetrance	J:138501
Spi1^tm1Rpd/Spi1^tm1Rpd involves: 129/Sv * C57BL/6 * Black Swiss	abnormal common myeloid progenitor cell morphology	J:123079
	abnormal myelopoiesis	J:123079
	arrested B cell differentiation	J:123079
	decreased body size	J:123079
	enlarged spleen	J:123079
	failure of tooth eruption	J:123079
	impaired myelopoiesis	J:123079
	liver hyperplasia	J:123079
	osteopetrosis	J:123079
	postnatal lethality, incomplete penetrance	J:123079
Spi1^tm1Sing/Spi1^tm1Sing involves: 129S/SvEv	abnormal B cell differentiation	J:20348
	abnormal common myeloid progenitor cell morphology	J:138501
	abnormal erythropoiesis	J:20348
	abnormal granulocyte morphology	J:20348
	abnormal leukopoiesis	J:20348
	abnormal monocyte morphology	J:20348
	abnormal T cell differentiation	J:20348
	anemia	J:20348
	decreased hematocrit	J:20348
	lethality throughout fetal growth and development, complete penetrance	J:20348, J:138501
Spi1^tm2.1Dgt/Spi1^tm2.1Dgt B6.Cg-Spi1^tm2.1Dgt	abnormal blood cell morphology/development	J:114150
	abnormal hematopoietic system physiology	J:114150
	decreased hematopoietic stem cell number	J:114150
	prenatal lethality, complete penetrance	J:114150
Spi1^tm2.1Dgt/Spi1^tm2Dgt Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal blood cell morphology/development	J:114150
Spi1^{tm2b(EUCOMM)Wtsi}/Spi1⁺ C57BL/6N-Spi1^{tm2b(EUCOMM)Wtsi}/J	decreased erythrocyte cell number	J:211773
	increased mean corpuscular volume	J:211773
Spi1^{tm2b(EUCOMM)Wtsi}/Spi1^{tm2b(EUCOMM)Wtsi} C57BL/6N-Spi1^{tm2b(EUCOMM)Wtsi}/J	hemorrhage	J:211773
	preweaning lethality, complete penetrance	J:211773
Spi1^tm2Dgt/Spi1^tm2Dgt B6.Cg-Spi1^tm2Dgt	abnormal blood cell morphology/development	J:114150
Spi1^tm2Dgt/Spi1^tm2Dgt Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal blood cell morphology/development	J:114150
Spi1^tm3Dgt/Spi1^tm3Dgt involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased B cell number	J:131217
	decreased double-negative T cell number	J:131217
	increased double-negative T cell number	J:131217
	increased granulocyte number	J:131217
Spi1^tm4.1Dgt/Spi1^tm4.1Dgt B6.129(Cg)-Spi1^tm4.1Dgt	abnormal cell cycle	J:196609
	abnormal hematopoietic stem cell physiology	J:196609
	normal hematopoietic system phenotype	J:196609
	increased bone marrow cell number	J:196609
	increased hematopoietic stem cell number	J:196609
	increased hematopoietic stem cell proliferation	J:196609

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