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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spi1
Spi-1 proto-oncogene
MGI:98282
97 phenotypes from 17 alleles in 21 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Spi1tm2Dgt/Spi1tm2Dgt
involves: 129P2/OlaHsd * C57BL/6 		normal hematopoietic system phenotype J:114150
Spi1tm1.1Dgt/Spi1tm1.1Dgt
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone marrow morphology J:90331
abnormal definitive hematopoiesis J:90331
abnormal erythrocyte cell number J:90331
abnormal spleen morphology J:90331
decreased B cell number J:90331
enlarged liver J:90331
enlarged spleen J:90331
increased leukemia incidence J:90331
increased T cell derived lymphoma incidence J:90331
increased tumor incidence J:90331
premature death J:90331
spleen hyperplasia J:90331
Spi1tm1.1Nutt/Spi1tm1.1Nutt
involves: C57BL/6 * BALB/cJ 		absent common myeloid progenitor cells J:98188
Spi1tm1.1Rpd/Spi1tm1.1Rpd
involves: 129/Sv * Black Swiss * FVB/N 		abnormal common myeloid progenitor cell morphology J:138501
postnatal lethality, complete penetrance J:138501
Spi1tm1.2Dgt/Spi1tm1.2Dgt
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:106788
Spi1tm1.2Nutt/Spi1tm1.2Nutt
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal bone marrow cell morphology/development J:98188
abnormal granulocyte differentiation J:98188
abnormal spleen morphology J:98188
absent common myeloid progenitor cells J:98188
absent erythrocytes J:98188
decreased B cell number J:98188
extramedullary hematopoiesis J:98188
increased granulocyte number J:98188
Spi1tm1.3Dgt/Spi1tm1.3Dgt
involves: 129 * BALB/c * C57BL/6 		abnormal chromosome number J:90331
abnormal definitive hematopoiesis J:90331
abnormal liver morphology J:90331
abnormal proerythroblast morphology J:90331
abnormal spleen morphology J:90331
decreased B cell number J:90331
enlarged spleen J:90331
increased leukemia incidence J:90331
increased liver weight J:90331
increased neutrophil cell number J:90331
increased spleen weight J:90331
increased T cell derived lymphoma incidence J:90331
liver hyperplasia J:90331
premature death J:90331
spleen hyperplasia J:90331
Spi1tm1.3Dgt/Spi1tm1.3Dgt
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		abnormal double-negative T cell morphology J:106040
abnormal T cell subpopulation ratio J:106040
arrested B cell differentiation J:106040
decreased B-1a cell number J:106040
decreased granulocyte number J:106040
decreased mature B cell number J:106040
decreased pre-B cell number J:106040
decreased pro-B cell number J:106040
decreased T cell number J:106040
decreased thymocyte number J:106040
increased B-1 B cell number J:106040
increased B-1b cell number J:106040
increased IgM level J:106040
increased leukemia incidence J:106040
increased lymphocyte cell number J:106040
increased T cell derived lymphoma incidence J:106040
increased T cell number J:106040
premature death J:106040
small thymus J:106040
Spi1tm1.3Nutt/Spi1tm1.3Nutt
C57BL/6-Sfpi1tm1.3Nutt 		absent common myeloid progenitor cells J:98188
neonatal lethality, complete penetrance J:98188
Spi1tm1Kast/Spi1+
B6.129S2-Spi1tm1Kast 		abnormal erythropoiesis J:90543
increased bone marrow cell number J:196609
increased hematopoietic stem cell number J:196609
Spi1tm1Kast/Spi1tm1Kast
B6.129S2-Spi1tm1Kast 		abnormal erythropoiesis J:90543
abnormal fetal derived definitive erythrocyte cell number J:90543
absent B cells J:90543
failure of myelopoiesis J:90543
neonatal lethality, complete penetrance J:90543
Spi1tm1Nutt/Spi1tm1Nutt
involves: C57BL/6 		no abnormal phenotype detected J:95651
Spi1tm1Ram/Spi1+
involves: 129S2/SvPas 		abnormal eye development J:101493
persistence of hyaloid vascular system J:101493
Spi1tm1Ram/Spi1tm1Ram
involves: 129S2/SvPas 		abnormal eye development J:101493
decreased macrophage cell number J:101493
normal homeostasis/metabolism phenotype J:95801
persistence of hyaloid vascular system J:101493
Spi1tm1Ram/Spi1tm1Ram
involves: 129S2/SvPas * C57BL/6 		abnormal astrocyte morphology J:116087
abnormal B cell number J:36473
abnormal liver morphology J:36473
abnormal macrophage differentiation J:36473
abnormal microglial cell morphology J:116087
abnormal neutrophil differentiation J:36473
abnormal T cell differentiation J:36473
abnormal T cell number J:36473
absent mature B cells J:36473
decreased CD4-positive, alpha-beta T cell number J:36473
decreased CD8-positive, alpha-beta T cell number J:36473
decreased double-positive T cell number J:36473
decreased macrophage cell number J:36473
decreased neutrophil cell number J:36473
decreased spleen red pulp amount J:36473
decreased thymocyte number J:36473
neonatal lethality, complete penetrance J:36473
postnatal growth retardation J:116087
premature death J:116087
sepsis J:36473
Spi1tm1Rpd/Spi1tm1Rpd
involves: 129 		abnormal common myeloid progenitor cell morphology J:138501
postnatal lethality, incomplete penetrance J:138501
Spi1tm1Rpd/Spi1tm1Rpd
involves: 129/Sv * C57BL/6 * Black Swiss 		abnormal common myeloid progenitor cell morphology J:123079
abnormal myelopoiesis J:123079
arrested B cell differentiation J:123079
decreased body size J:123079
enlarged spleen J:123079
failure of tooth eruption J:123079
impaired myelopoiesis J:123079
liver hyperplasia J:123079
osteopetrosis J:123079
postnatal lethality, incomplete penetrance J:123079
Spi1tm1Sing/Spi1tm1Sing
involves: 129S/SvEv 		abnormal B cell differentiation J:20348
abnormal common myeloid progenitor cell morphology J:138501
abnormal erythropoiesis J:20348
abnormal granulocyte morphology J:20348
abnormal leukopoiesis J:20348
abnormal monocyte morphology J:20348
abnormal T cell differentiation J:20348
anemia J:20348
decreased hematocrit J:20348
lethality throughout fetal growth and development, complete penetrance J:20348, J:138501
Spi1tm2.1Dgt/Spi1tm2.1Dgt
B6.Cg-Spi1tm2.1Dgt 		abnormal blood cell morphology/development J:114150
abnormal hematopoietic system physiology J:114150
decreased hematopoietic stem cell number J:114150
prenatal lethality, complete penetrance J:114150
Spi1tm2.1Dgt/Spi1tm2Dgt
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal blood cell morphology/development J:114150
Spi1tm2b(EUCOMM)Wtsi/Spi1+
C57BL/6N-Spi1tm2b(EUCOMM)Wtsi/J 		decreased erythrocyte cell number J:211773
increased mean corpuscular volume J:211773
Spi1tm2b(EUCOMM)Wtsi/Spi1tm2b(EUCOMM)Wtsi
C57BL/6N-Spi1tm2b(EUCOMM)Wtsi/J 		hemorrhage J:211773
preweaning lethality, complete penetrance J:211773
Spi1tm2Dgt/Spi1tm2Dgt
B6.Cg-Spi1tm2Dgt 		abnormal blood cell morphology/development J:114150
Spi1tm2Dgt/Spi1tm2Dgt
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal blood cell morphology/development J:114150
Spi1tm3Dgt/Spi1tm3Dgt
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased B cell number J:131217
decreased double-negative T cell number J:131217
increased double-negative T cell number J:131217
increased granulocyte number J:131217
Spi1tm4.1Dgt/Spi1tm4.1Dgt
B6.129(Cg)-Spi1tm4.1Dgt 		abnormal cell cycle J:196609
abnormal hematopoietic stem cell physiology J:196609
normal hematopoietic system phenotype J:196609
increased bone marrow cell number J:196609
increased hematopoietic stem cell number J:196609
increased hematopoietic stem cell proliferation J:196609
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory