Srsf2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Srsf2
serine and arginine-rich splicing factor 2
MGI:98284

30 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myl2^tm1(cre)Krc/Myl2⁺ Srsf2^tm1Xdfu/Srsf2^tm1Xdfu involves: 129S4/SvJae	cardiac interstitial fibrosis	J:88432
	normal cardiovascular system phenotype	J:88432
	decreased heart left ventricle muscle contractility	J:88432
	decreased heart ventricle muscle contractility	J:88432
	dilated cardiomyopathy	J:88432
	pregnancy-related premature death	J:88432
Srsf2^tm1.1Oaw/Srsf2⁺ Tg(Mx1-cre)1Cgn/? B6.Cg-Tg(Mx1-cre)1Cgn Srsf2^tm1.1Oaw	abnormal cell cycle	J:221404
	abnormal erythroid progenitor cell morphology	J:221404
	abnormal erythropoiesis	J:221404
	abnormal hematopoietic stem cell physiology	J:221404
	abnormal hematopoietic system physiology	J:221404
	abnormal myelopoiesis	J:221404
	abnormal neutrophil morphology	J:221404
	decreased B cell number	J:221404
	failure of myelopoiesis	J:221404
	impaired hematopoiesis	J:221404
	increased apoptosis	J:221404
	increased hematopoietic stem cell number	J:221404
	macrocytic anemia	J:221404
Srsf2^tm1.1Xdfu/Srsf2^tm1.1Xdfu involves: 129S4/SvJae * FVB/N	embryonic lethality between implantation and somite formation, complete penetrance	J:88432
Srsf2^tm1Xdfu/Srsf2⁺ Tg(Lck-cre)I57Jxm/? involves: 129S4/SvJae * 129X1/SvJ * ICR	decreased thymocyte number	J:88668
	decreased thymus weight	J:88668
Srsf2^tm1Xdfu/Srsf2^tm1Xdfu Tg(Lck-cre)I57Jxm/? involves: 129S4/SvJae * 129X1/SvJ * ICR	abnormal spleen white pulp morphology	J:88668
	abnormal T cell differentiation	J:88668
	absent thymus corticomedullary boundary	J:88668
	decreased double-positive T cell number	J:88668
	decreased T cell number	J:88668
	decreased thymocyte number	J:88668
	increased double-negative T cell number	J:88668
	small thymus	J:88668
Srsf2^tm1Xdfu/Srsf2^tm1Xdfu Tg(Mx1-cre)1Cgn/? involves: 129S4/SvJae * C57BL/6J * CBA/J	abnormal hematopoietic system physiology	J:221404
	bone marrow failure	J:221404
	impaired hematopoiesis	J:221404

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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