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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Srsf3
serine and arginine-rich splicing factor 3
MGI:98285
89 phenotypes from 2 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Srsf3tm1Pjln/Srsf3tm1Pjln
involves: 129P2/OlaHsd * BALB/c 		decreased B cell number J:113645
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Srsf3tm1Pjln/Srsf3tm1Pjln
involves: BALB/c * C57BL/6J * CBA/J 		abnormal cartilage morphology J:308882
abnormal face development J:308882
abnormal facial morphology J:308882
abnormal forebrain morphology J:308882
abnormal hyoid bone greater horn morphology J:308882
abnormal hyoid bone lesser horn morphology J:308882
abnormal hyoid bone morphology J:308882
abnormal maxillary frontal process morphology J:308882
abnormal nasal pit morphology J:308882
abnormal neurocranium morphology J:308882
abnormal palate bone morphology J:308882
abnormal retrotympanic process morphology J:308882
abnormal styloid process morphology J:308882
abnormal temporal bone zygomatic process morphology J:308882
abnormal tracheal cartilage morphology J:308882
absent frontal bone J:308882
absent maxillary shelf J:308882
absent nasal bone J:308882
absent palatine bone horizontal plate J:308882
absent tympanic ring J:308882
basisphenoid bone hypoplasia J:308882
cricoid cartilage hypoplasia J:308882
decreased midbrain size J:308882
enlarged lateral ventricles J:308882
exencephaly J:308882
facial bone hypoplasia J:308882
facial cleft J:308882
increased forebrain size J:308882
internal hemorrhage J:308882
interparietal bone hypoplasia J:308882
lethality throughout fetal growth and development J:308882
mandible hypoplasia J:308882
mandibular coronoid process hypoplasia J:308882
maxilla hypoplasia J:308882
maxillary zygomatic process hypoplasia J:308882
Meckel's cartilage hypoplasia J:308882
microcephaly J:308882
midbrain hypoplasia J:308882
palatal shelf hypoplasia J:308882
parietal bone hypoplasia J:308882
premaxilla hypoplasia J:308882
prenatal lethality, complete penetrance J:308882
pterygoid bone hypoplasia J:308882
small supraoccipital bone J:308882
temporal bone hypoplasia J:308882
thyroid cartilage hypoplasia J:308882
tongue hypoplasia J:308882
wavy neural tube J:308882
zygomatic bone hypoplasia J:308882
Srsf3tm1.1Pjln/Srsf3tm1.1Pjln
involves: BALB/c 		abnormal preimplantation embryo development J:57047
embryonic lethality before implantation, complete penetrance J:57047
failure of blastocyst formation J:57047
Srsf3tm1Pjln/Srsf3tm1Pjln
involves: BALB/c 		no abnormal phenotype detected J:57047
Srsf3tm1Pjln/Srsf3tm1Pjln
Cd79atm1(cre)Reth/Cd79a+
involves: 129P2/OlaHsd * BALB/c 		decreased B cell number J:113645
decreased pre-B cell number J:113645
decreased pro-B cell number J:113645
Srsf3tm1Pjln/Srsf3tm1Pjln
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: BALB/c * C57BL/6 * DBA 		abnormal bile canaliculus morphology J:205756
abnormal endoplasmic reticulum morphology J:205756
abnormal glucose tolerance J:205756
abnormal hepatobiliary system development J:205756
abnormal hepatocyte morphology J:205756
abnormal kidney development J:205756
abnormal liver morphology J:205756
abnormal liver sinusoid morphology J:205756
abnormal thymus development J:205756
decreased body size J:205756
decreased brown adipose tissue amount J:205756
decreased circulating cholesterol level J:205756
decreased circulating HDL cholesterol level J:205756
decreased circulating insulin-like growth factor I level J:205756
decreased circulating serum albumin level J:205756
decreased circulating triglyceride level J:205756
decreased fatty acid oxidation J:205756
decreased liver cholesterol level J:205756
decreased liver glycogen level J:205756
decreased liver triglyceride level J:205756
decreased susceptibility to diet-induced obesity J:205756
hypoglycemia J:205756
increased circulating alanine transaminase level J:205756
increased circulating alkaline phosphatase level J:205756
increased circulating aspartate transaminase level J:205756
increased circulating bilirubin level J:205756
increased circulating growth hormone level J:205756
increased hepatocyte apoptosis J:205756
increased insulin sensitivity J:205756
pale liver J:205756
perinatal lethality, incomplete penetrance J:205756
postnatal lethality, incomplete penetrance J:205756
small liver J:205756
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory