Shc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296

46 phenotypes from 8 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9.1Paw involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:122927
Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9Paw involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:122927
Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm9Paw/Shc1^tm9Paw involves: 129S1/Sv * 129X1/SvJ	abnormal locomotor coordination	J:122927
	ataxia	J:122927
	decreased muscle spindle number	J:122927
	impaired limb coordination	J:122927
Shc1^tm1Lex/Shc1^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:103485
Shc1^tm1Paw/Shc1^tm1Paw either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	abnormal actin cytoskeleton morphology	J:62182
	abnormal atrioventricular cushion morphology	J:62182
	abnormal blood vessel morphology	J:62182
	abnormal carotid artery morphology	J:62182
	abnormal cell adhesion	J:62182
	abnormal cell morphology	J:62182
	abnormal cell physiology	J:62182
	abnormal heart left ventricle morphology	J:62182
	abnormal vascular endothelial cell morphology	J:62182
	abnormal vascular smooth muscle morphology	J:62182
	abnormal vein morphology	J:62182
	abnormal vitelline vasculature morphology	J:62182
	atrioventricular cushion hypoplasia	J:62182
	decreased angiogenesis	J:62182
	decreased cardiac muscle contractility	J:62182
	decreased heart left ventricle wall thickness	J:62182
	embryonic lethality during organogenesis, complete penetrance	J:62182
	enlarged pericardium	J:62182
	heart vascular congestion	J:62182
	pale yolk sac	J:62182
	thin myocardium	J:62182
	trabecula carnea hypoplasia	J:62182
	vascular smooth muscle hypoplasia	J:62182
Shc1^tm1Pgp/Shc1^tm1Pgp involves: 129	atherosclerotic lesions	J:81977
	decreased cellular sensitivity to hydrogen peroxide	J:58535, J:81977
	decreased cellular sensitivity to oxidative stress	J:58535
	decreased cellular sensitivity to ultraviolet irradiation	J:58535, J:81977
	decreased susceptibility to atherosclerosis	J:81977
	extended life span	J:58535
	normal growth/size/body region phenotype	J:58535
	normal homeostasis/metabolism phenotype	J:81977
	increased vasodilation	J:81977
	oxidative stress	J:81977
Shc1^tm1Ravi/Shc1^tm1Ravi Tg(Lck-cre)1Cwi/? involves: 129 * C57BL/6	abnormal double-negative T cell morphology	J:78180
	decreased double-positive T cell number	J:78180
	decreased single-positive T cell number	J:78180
	thymus hypoplasia	J:78180
Shc1^tm1Ravi/Shc1^tm1Ravi Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6 * SJL	decreased body weight	J:111058
	decreased brain size	J:111058
Shc1^tm2Paw/Shc1^tm2Paw involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:122927
Shc1^tm8Paw/Shc1^tm9.1Paw involves: 129S1/Sv * 129X1/SvJ	embryonic lethality during organogenesis, complete penetrance	J:122927
Shc1^tm8Paw/Shc1^tm9.1Paw Tg(Myh6-cre)2182Mds/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	embryonic lethality during organogenesis, incomplete penetrance	J:122927

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24