Shc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296

46 phenotypes from 8 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9.1Paw involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:122927
Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9Paw involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:122927
Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm9Paw/Shc1^tm9Paw involves: 129S1/Sv * 129X1/SvJ	abnormal locomotor coordination	J:122927
	ataxia	J:122927
	decreased muscle spindle number	J:122927
	impaired limb coordination	J:122927
Shc1^tm1Lex/Shc1^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:103485
Shc1^tm1Paw/Shc1^tm1Paw either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	abnormal actin cytoskeleton morphology	J:62182
	abnormal atrioventricular cushion morphology	J:62182
	abnormal blood vessel morphology	J:62182
	abnormal carotid artery morphology	J:62182
	abnormal cell adhesion	J:62182
	abnormal cell morphology	J:62182
	abnormal cell physiology	J:62182
	abnormal heart left ventricle morphology	J:62182
	abnormal vascular endothelial cell morphology	J:62182
	abnormal vascular smooth muscle morphology	J:62182
	abnormal vein morphology	J:62182
	abnormal vitelline vasculature morphology	J:62182
	atrioventricular cushion hypoplasia	J:62182
	decreased angiogenesis	J:62182
	decreased cardiac muscle contractility	J:62182
	decreased heart left ventricle wall thickness	J:62182
	embryonic lethality during organogenesis, complete penetrance	J:62182
	enlarged pericardium	J:62182
	heart vascular congestion	J:62182
	pale yolk sac	J:62182
	thin myocardium	J:62182
	trabecula carnea hypoplasia	J:62182
	vascular smooth muscle hypoplasia	J:62182
Shc1^tm1Pgp/Shc1^tm1Pgp involves: 129	atherosclerotic lesions	J:81977
	decreased cellular sensitivity to hydrogen peroxide	J:58535, J:81977
	decreased cellular sensitivity to oxidative stress	J:58535
	decreased cellular sensitivity to ultraviolet irradiation	J:58535, J:81977
	decreased susceptibility to atherosclerosis	J:81977
	extended life span	J:58535
	normal growth/size/body region phenotype	J:58535
	normal homeostasis/metabolism phenotype	J:81977
	increased vasodilation	J:81977
	oxidative stress	J:81977
Shc1^tm1Ravi/Shc1^tm1Ravi Tg(Lck-cre)1Cwi/? involves: 129 * C57BL/6	abnormal double-negative T cell morphology	J:78180
	decreased double-positive T cell number	J:78180
	decreased single-positive T cell number	J:78180
	thymus hypoplasia	J:78180
Shc1^tm1Ravi/Shc1^tm1Ravi Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6 * SJL	decreased body weight	J:111058
	decreased brain size	J:111058
Shc1^tm2Paw/Shc1^tm2Paw involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:122927
Shc1^tm8Paw/Shc1^tm9.1Paw involves: 129S1/Sv * 129X1/SvJ	embryonic lethality during organogenesis, complete penetrance	J:122927
Shc1^tm8Paw/Shc1^tm9.1Paw Tg(Myh6-cre)2182Mds/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	embryonic lethality during organogenesis, incomplete penetrance	J:122927

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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