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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myl1tm1(cre)Sjb/Myl1+
Shc1tm3Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
decreased muscle spindle number J:122927
impaired limb coordination J:122927
Myl1tm1(cre)Sjb/Myl1+
Shc1tm4Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
abnormal muscle spindle morphology J:122927
ataxia J:122927
Myl1tm1(cre)Sjb/Myl1+
Shc1tm7Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
ataxia J:122927
decreased muscle spindle number J:122927
impaired limb coordination J:122927
Shc1tm3Paw/Shc1tm3Paw
involves: 129S1/Sv * 129X1/SvJ 		prenatal lethality, incomplete penetrance J:122927
Shc1tm3Paw/Shc1tm4Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
decreased muscle spindle number J:122927
Shc1tm3Paw/Shc1tm7Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
decreased muscle spindle number J:122927
Shc1tm4Paw/Shc1tm4Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal cardiovascular system physiology J:122927
abnormal excitatory postsynaptic potential J:122927
abnormal muscle spindle morphology J:122927
abnormal myocardial trabeculae morphology J:122927
abnormal nerve conduction J:122927
ataxia J:122927
embryonic lethality during organogenesis, complete penetrance J:122927
Shc1tm5Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm5Paw/Shc1tm5Paw
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:122927
Shc1tm5Paw/Shc1tm5Paw
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm6Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm6Paw/Shc1tm6Paw
involves: 129S1/Sv * 129X1/SvJ 		prenatal lethality, incomplete penetrance J:122927
Shc1tm6Paw/Shc1tm6Paw
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm7Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm7Paw/Shc1tm7Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal excitatory postsynaptic potential J:122927
abnormal locomotor coordination J:122927
abnormal motor neuron morphology J:122927
abnormal muscle spindle morphology J:122927
abnormal nerve conduction J:122927
ataxia J:122927
impaired limb coordination J:122927
prenatal lethality J:122927
Shc1tm9Paw/Shc1tm9Paw
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
normal neoplasm J:133325
normal reproductive system phenotype J:133325
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory