About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296
20 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Myl1tm1(cre)Sjb/Myl1+
Shc1tm3Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
decreased muscle spindle number J:122927
impaired limb coordination J:122927
Myl1tm1(cre)Sjb/Myl1+
Shc1tm4Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
abnormal muscle spindle morphology J:122927
ataxia J:122927
Myl1tm1(cre)Sjb/Myl1+
Shc1tm7Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
ataxia J:122927
decreased muscle spindle number J:122927
impaired limb coordination J:122927
Shc1tm3Paw/Shc1tm3Paw
involves: 129S1/Sv * 129X1/SvJ 		prenatal lethality, incomplete penetrance J:122927
Shc1tm3Paw/Shc1tm4Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
decreased muscle spindle number J:122927
Shc1tm3Paw/Shc1tm7Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
decreased muscle spindle number J:122927
Shc1tm4Paw/Shc1tm4Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal cardiovascular system physiology J:122927
abnormal excitatory postsynaptic potential J:122927
abnormal muscle spindle morphology J:122927
abnormal myocardial trabeculae morphology J:122927
abnormal nerve conduction J:122927
ataxia J:122927
embryonic lethality during organogenesis, complete penetrance J:122927
Shc1tm5Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm5Paw/Shc1tm5Paw
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:122927
Shc1tm5Paw/Shc1tm5Paw
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm6Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm6Paw/Shc1tm6Paw
involves: 129S1/Sv * 129X1/SvJ 		prenatal lethality, incomplete penetrance J:122927
Shc1tm6Paw/Shc1tm6Paw
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm7Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
decreased metastatic potential J:133325
increased mammary gland tumor incidence J:133325
increased tumor latency J:133325
Shc1tm7Paw/Shc1tm7Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal excitatory postsynaptic potential J:122927
abnormal locomotor coordination J:122927
abnormal motor neuron morphology J:122927
abnormal muscle spindle morphology J:122927
abnormal nerve conduction J:122927
ataxia J:122927
impaired limb coordination J:122927
prenatal lethality J:122927
Shc1tm9Paw/Shc1tm9Paw
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
normal neoplasm J:133325
normal reproductive system phenotype J:133325
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory