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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Shh
sonic hedgehog
MGI:98297
278 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Shh+/Shhtm1Chg
Zic2Ku/Zic2+
involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH 		no abnormal phenotype detected J:138862
Artm2Ska/Y
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S6/SvEvTac * C57BL/6 * CBA 		normal reproductive system phenotype J:148515
Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr
Shhtm1(EGFP/cre)Cjt/?
involves: 129S7/SvEvBrd 		preweaning lethality, complete penetrance J:166768
Ccd/Ccd+
ShhDsh/Shh+
involves: 101 * C3H * C57BL * C57BL/10Rl * SEC 		abnormal clavicle morphology J:16170
abnormal cranium morphology J:16170
abnormal hindlimb morphology J:16170
abnormal humerus morphology J:16170
abnormal interparietal bone morphology J:16170
abnormal ischium morphology J:16170
abnormal maxilla morphology J:16170
abnormal neurocranium morphology J:16170
abnormal orbit morphology J:16170
abnormal pectoral girdle bone morphology J:16170
abnormal pelvic girdle bone morphology J:16170
abnormal pubis morphology J:16170
abnormal scapula morphology J:16170
abnormal temporal bone squamous part morphology J:16170
abnormal ventral tubercle of atlas morphology J:16170
abnormal vertebrae morphology J:16170
abnormal xiphoid process morphology J:16170
absent deltoid tuberosity J:16170
absent nasal bone J:16170
brachydactyly J:16170
fusion of atlas and odontoid process J:16170
occipital bone foramen J:16170
premature death J:16170
syndactyly J:16170
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/SvlmJ * 129S6/SvEvTac * C57BL/6J * SJL/J 		normal hearing/vestibular/ear phenotype J:310063
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129X1/SvJ 		abnormal lung development J:204743
abnormal lung vasculature morphology J:204743
abnormal pulmonary artery morphology J:204743
abnormal pulmonary vein morphology J:204743
absent lungs J:204743
normal cardiovascular system phenotype J:204743
tracheoesophageal fistula J:153098
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal reproductive system development J:223057
abnormal tail development J:223057
normal reproductive system phenotype J:223057
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal lung development J:153098
absent lung buds J:153098
absent lungs J:153098
Dicer1tm1Bdh/Dicer1+
Yy1tm2.1Yshi/Yy1+
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129 * 129S4/SvJae * C57BL/6 		normal respiratory system phenotype J:239777
Dicer1tm1Bdh/Dicer1tm1Bdh
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129 		abnormal lung development J:106072
abnormal lung epithelium morphology J:106072
perinatal lethality, complete penetrance J:106072
small lung lobe J:106072
Dicer1tm1Mmk/Dicer1tm1Mmk
Fgf9tm1.1Fwan/Fgf9+
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129 * 129S4/SvJaeSor * C57BL/6J 		normal respiratory system phenotype J:224791
Dicer1tm1Mmk/Dicer1tm1Mmk
Fgf9tm1.1Fwan/Fgf9tm1.1Fwan
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129 * 129S4/SvJaeSor * C57BL/6J 		normal respiratory system phenotype J:224791
Dicer1tm1Mmk/Dicer1tm1Mmk
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129 * C57BL/6J 		abnormal branching involved in lung morphogenesis J:224791
abnormal lung epithelium morphology J:224791
abnormal lung-associated mesenchyme development J:224791
enlarged lung J:224791
increased mesenchymal cell proliferation involved in lung development J:224791
lung cyst J:224791
Disp1icb/Disp1icb
Shhtm1Amc/Shhtm5Amc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129/Sv * C57BL/6J * SWR 		abnormal frontonasal prominence morphology J:94270
perinatal lethality, complete penetrance J:94270
Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129X1/SvJ * C57BL/6J 		oligodactyly J:92504
Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
involves: 129X1/SvJ * C57BL/6J 		abnormal neuron specification J:92058
failure of heart looping J:92058
holoprosencephaly J:92058
proboscis J:92058
Disp1icb/Disp1tm2Amc
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129/Sv * C57BL/6J * SWR 		abnormal facial morphology J:94270
abnormal nasal pit morphology J:94270
abnormal neuron differentiation J:94270
absent floor plate J:94270
absent parietal bone J:94270
absent premaxilla J:94270
neonatal lethality J:94270
Disp1tm1Pab/Disp1tm1Pab
Shhtm2Chg/Shh+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal digit morphology J:109101
perinatal lethality, complete penetrance J:109101
preaxial polydactyly J:109101
Disp1tm2.1Amc/Disp1tm2.1Amc
Shhtm1Amc/Shh+
involves: 129/Sv * C57BL/6J * SWR 		abnormal neuron differentiation J:94270
absent floor plate J:94270
Disp1tm2.1Amc/Disp1tm2Amc
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129/Sv * C57BL/6J * SWR 		abnormal facial morphology J:94270
abnormal nasal pit morphology J:94270
abnormal neuron differentiation J:94270
abnormal parietal bone morphology J:94270
absent premaxilla J:94270
neonatal lethality J:94270
E2f4tm2.1Lees/E2f4tm2.1Lees
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 		abnormal respiratory motile cilium morphology J:241925
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal urethra urothelium morphology J:223057
normal reproductive system phenotype J:223057
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S6/SvEvTac 		abnormal embryonic autopod plate morphology J:101736
oligodactyly J:101736
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S6/SvEvTac 		abnormal embryonic autopod plate morphology J:101736
oligodactyly J:101736
Fkbp8tm1Tili/Fkbp8tm1Tili
Shhtm1Chg/Shhtm1Chg
involves: C57BL/6 		abnormal dorsal-ventral axis patterning J:89364
abnormal limb morphology J:89364
abnormal neural tube morphology J:89364
abnormal somite shape J:89364
absent notochord J:89364
decreased somite size J:89364
microphthalmia J:89364
Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal respiratory system development J:185603
decreased club cell number J:185603
neonatal lethality, complete penetrance J:185603
respiratory distress J:185603
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal mortality/aging J:185603
Gas1tm1Fan/Gas1tm1Fan
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal basisphenoid bone morphology J:122159
abnormal craniofacial bone morphology J:122159
abnormal incisor morphology J:122159
abnormal lower incisor morphology J:122159
abnormal mandible morphology J:122159
abnormal Meckel's cartilage morphology J:122159
abnormal middle ear morphology J:122159
abnormal molar morphology J:122159
abnormal nasal capsule morphology J:122159
abnormal neurocranium morphology J:122159
abnormal premaxilla morphology J:122159
abnormal stapes morphology J:122159
abnormal temporal bone morphology J:122159
absent gonial bone J:122159
absent incus J:122159
absent malleus J:122159
absent mandibular symphysis J:122159
absent tympanic ring J:122159
alisphenoid bone hypoplasia J:122159
cleft secondary palate J:122159
holoprosencephaly J:122159
perinatal lethality, complete penetrance J:122159
premature coronal suture closure J:122159
premaxilla hypoplasia J:122159
short Meckel's cartilage J:122159
single external naris J:122159
small cranium J:122159
synostosis J:122159
Gas1tm1Fan/Gas1tm1Fan
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal craniofacial morphology J:122159
embryonic lethality, complete penetrance J:122159
Gas1tm2Fan/Gas1+
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		increased neuronal precursor cell number J:121553
Gas1tm2Fan/Gas1tm2Fan
Shhtm1Chg/Shh+
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J 		holoprosencephaly J:121554
oligodactyly J:121554
single external naris J:121554
Gas1tm2Fan/Gas1tm2Fan
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal craniofacial morphology J:121553
abnormal floor plate morphology J:121553
abnormal innervation J:121553
abnormal intervertebral disk morphology J:121553
abnormal nose morphology J:121553
abnormal vertebral body morphology J:121553
decreased fetal size J:121553
decreased neuronal precursor cell number J:121553
forelimb oligodactyly J:121553
short mandible J:121553
Gas1tm2Fan/Gas1tm2Fan
Shhtm1Chg/Shhtm1Chg
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal embryo turning J:121554
abnormal heart tube morphology J:121554
abnormal rostral-caudal body axis extension J:121554
cardiac edema J:121554
decreased embryo size J:121554
embryonic growth arrest J:121554
embryonic lethality during organogenesis, complete penetrance J:121554
enlarged pericardium J:121554
Gata6tm2.1Sad/Gata6tm2.1Sad
Shhtm2Amc/Shhtm2Amc
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J 		hindlimb oligodactyly J:205405
Gli1tm1Alj/Gli1tm1Alj
Tg(Shh)#Dje/0
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		abnormal cell proliferation J:94461
abnormal cerebellar granule layer morphology J:94461
abnormal cerebellar lobule formation J:94461
abnormal cerebellum external granule cell layer morphology J:94461
abnormal cerebellum morphology J:94461
Gli2tm1Blnw/Gli2tm1Blnw
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal cellular phenotype J:145182
normal nervous system phenotype J:145182
Gli2tm2.1Alj/Gli2+
Shhtm1Chg/Shhtm1Chg
either: (involves: 129) or (involves: 129 * Black Swiss) 		abnormal spinal cord morphology J:73074
abnormal telencephalon development J:73074
decreased embryo size J:73074
Gli2tm2.1Alj/Gli2tm2.1Alj
Shhtm1Chg/Shhtm1Chg
either: (involves: 129) or (involves: 129 * Black Swiss) 		abnormal spinal cord interneuron morphology J:73074
absent floor plate J:73074
cyclopia J:73074
decreased motor neuron number J:73074
Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj
Shhtm1Chg/Shhtm1Chg
either: (involves: 129) or (involves: 129 * Black Swiss) 		abnormal diencephalon morphology J:73074
abnormal ventral interneuron 3 morphology J:73074
absent floor plate J:73074
decreased motor neuron number J:73074
megacephaly J:73074
Gli3tm2Blnw/Gli3+
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal autopod morphology J:121609
abnormal digit morphology J:121609
abnormal limb morphology J:121609
abnormal phalanx morphology J:121609
absent tibia J:121609
polydactyly J:121609
short tibia J:121609
synostosis J:121609
Gt(ROSA)26Sortm1(CAG-Bmpr1a)Que/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/?
Not Specified 		abnormal esophageal epithelium morphology J:166768
abnormal forestomach morphology J:166768
preweaning lethality, complete penetrance J:166768
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S6/SvEvTac 		abnormal genital tubercle morphology J:223057
abnormal reproductive system physiology J:223057
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt
involves: 129S6/SvEvTac 		abnormal genital tubercle morphology J:223057
Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt
Tg(Msx2-cre)5Rem/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal limb development J:223057
Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/0
involves: 129S1/Sv 		polyphalangy J:214075
postaxial polydactyly J:214075
preaxial polydactyly J:214075
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		normal vision/eye phenotype J:118372
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S6/SvEvTac * 129X1/SvJ 		normal neoplasm J:139574
Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal lung morphology J:202984
lung cyst J:202984
small lung J:202984
Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
Not Specified 		normal limbs/digits/tail phenotype J:223057
Gt(ROSA)26Sortm4(CAG-lacZ,-EGFP)Dym/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
involves: C57BL/6 		abnormal skin morphology J:132568
thin epidermis J:132568
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Shhtm1Amc/Shhtm2Amc
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster 		abnormal digit morphology J:149478
HhatTg(TFAP2A-cre)1Will/Hhat+
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial morphology J:190013
Ift88tm1Bky/Ift88tm1Bky
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129P2/OlaHsd 		abnormal palatal rugae morphology J:281425
Ift122sopb/Ift122sopb
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J 		abnormal neural tube morphology J:168317
exencephaly J:168317
open neural tube J:168317
Ihhtm1Amc/Ihhtm1Amc
Shhtm1Amc/Shhtm1Amc
involves: 129/Sv * C57BL/6J * CBA/J 		embryonic growth arrest J:62158
Ihhtm1Amc/Ihhtm1Amc
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal visceral yolk sac mesenchyme morphology J:128367
abnormal visceral yolk sac morphology J:128367
absent vitelline blood vessels J:128367
failure of initiation of embryo turning J:128367
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac 		normal integument phenotype J:172048
Krastm4Tyj/Kras+
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S4/SvJae * 129S6/SvEvTac 		normal integument phenotype J:172048
Ndst1tm1.1Grob/Ndst1+
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal eye development J:100425
abnormal maxillary prominence morphology J:100425
absent olfactory epithelium J:100425
absent tongue J:100425
aphakia J:100425
frontonasal prominence hypoplasia J:100425
mandible hypoplasia J:100425
microphthalmia J:100425
small snout J:100425
Ndst1tm1.1Grob/Ndst1tm1.1Grob
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal forebrain morphology J:100425
abnormal maxillary prominence morphology J:100425
abnormal midbrain morphology J:100425
frontonasal prominence hypoplasia J:100425
prenatal lethality J:100425
Nr5a1tm1.1Hain/Nr5a1tm1.1Hain
Shhtm1Amc/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal aldosterone level J:175843
Pofut1tm2Pst/Pofut1tm1Pst
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL 		abnormal bronchiole epithelium morphology J:150051
abnormal respiratory epithelium morphology J:150051
absent club cells J:150051
decreased birth body size J:150051
decreased body size J:150051
increased solitary pulmonary neuroendocrine cell number J:150051
lung inflammation J:150051
postnatal lethality, incomplete penetrance J:150051
premature death J:150051
normal respiratory system phenotype J:150051
Ptch1tm1Mps/Ptch1+
Tg(Shh)#Dje/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:108507
abnormal cerebellum development J:108507
abnormal cerebellum morphology J:108507
Ptch1tm1Mps/Ptch1+
Shhtm6Amc/Shhtm6Amc
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:132152
Rbpjtm1Hon/Rbpjtm1.1Hon
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal respiratory epithelium morphology J:150051
absent club cells J:150051
Robo1tm1Matl/Robo1tm1Matl
Robo2tm1Rilm/Robo2tm1Rilm
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129 		no abnormal phenotype detected J:193400
Rr26tm1Svok/Rr26tm1Svok
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ 		normal limbs/digits/tail phenotype J:207959
Rr29tm1.1Bobh/Rr29+
Shhtm1Chg/Shh+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal limb morphology J:208849
oligodactyly J:208849
Rr45tm1.1Tshir/Rr45+
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/JNCrlj 		abnormal arytenoid cartilage morphology J:148018
epiglottis hypoplasia J:148018
Rr115em1Bobh/Rr115+
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal adenohypophysis development J:306254
abnormal hypothalamus morphology J:306254
abnormal magnocellular neurosecretory cell morphology J:306254
abnormal maxilla morphology J:306254
abnormal nasal cavity morphology J:306254
abnormal neurohypophysis development J:306254
abnormal parvocellular neurosecretory cell morphology J:306254
abnormal pterygoid bone morphology J:306254
abnormal Rathke's pouch development J:306254
basisphenoid bone hypoplasia J:306254
ectopic neurohypophysis J:306254
perinatal lethality, complete penetrance J:306254
round head J:306254
vomer bone hypoplasia J:306254
Rr117tm1.1Dje/Rr117+
Shhtm1Amc/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N 		normal behavior/neurological phenotype J:170540
normal homeostasis/metabolism phenotype J:170540
postnatal lethality, incomplete penetrance J:170540
slow postnatal weight gain J:170540
ShhDsh/Shh+
B10Rl.Cg-ShhDsh 		abnormal cartilage development J:97323
abnormal cartilage morphology J:97323
abnormal chondrocyte differentiation J:97323
abnormal cranium morphology J:16170
abnormal frontal bone morphology J:14105, J:16170
abnormal hindlimb morphology J:16170
abnormal joint morphology J:97323
abnormal maxilla morphology J:16170
abnormal neurocranium morphology J:16170
abnormal phalanx morphology J:14105, J:97323
abnormal rib morphology J:14105, J:16170
abnormal vertebrae morphology J:16170
brachydactyly J:14105, J:16170, J:97323
brachyphalangia J:14105, J:97323
cervical vertebral fusion J:14105
decreased chondrocyte proliferation J:97323
fused joints J:97323
fusion of atlas and odontoid process J:16170
occipital bone foramen J:16170
short metacarpal bones J:97323
syndactyly J:14105, J:16170, J:97323
thin interparietal bone J:16170
ShhDsh/Shh+
involves: 101 * C3H * C57BL * SEC 		brachydactyly J:14105
ShhDsh/ShhDsh
B10Rl.Cg-ShhDsh 		decreased embryo size J:16170
prenatal lethality, incomplete penetrance J:16170
short limbs J:16170
ShhDsh/ShhDsh
involves: 101 * C3H * C57BL * SEC 		abnormal ear morphology J:14105, J:16170
abnormal embryo size J:14105, J:16170
absent external female genitalia J:14105, J:16170
absent external male genitalia J:14105, J:16170
absent mouth J:14105, J:16170
anophthalmia J:14105
brachydactyly J:16170
cyclopia J:16170
embryonic lethality during organogenesis, incomplete penetrance J:14105, J:16170
microcephaly J:14105, J:16170
neonatal lethality, complete penetrance J:16170
short limbs J:14105, J:16170
ShhDsh/Shhtm1Chg
involves: 101 * 129S1/Sv * 129X1/SvJ * C3H * C57BL/10Rl 		abnormal dorsal-ventral axis patterning J:97323
abnormal limb morphology J:97323
Shhtm1(EGFP/cre)Cjt/Shh+
Sox17tm1Ysk/Sox17+
involves: 129S1/Sv * C57BL/6 		abnormal gallbladder smooth muscle morphology J:241569
Shhtm1(EGFP/cre)Cjt/Shh+
Sox9tm2Crm/Sox9tm2Crm
B6.Cg-Shhtm1(EGFP/cre)Cjt Sox9tm2Crm 		abnormal primitive urogenital sinus morphology J:281428
Shhtm1Amc/Shhtm1Amc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-Shh)1Jaw/0
involves: FVB/N 		abnormal lung lobe morphology J:91723
absent tracheal cartilage rings J:91723
neonatal lethality, complete penetrance J:91723
Shhtm1Chg/Shh+
Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg
Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 		abnormal craniofacial morphology J:130163
absent mandible J:130163
anophthalmia J:130163
microphthalmia J:130163
short mandible J:130163
Shhtm1Chg/Shh+
Vps25m1Lis/Vps25m1Lis
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J 		abnormal outer ear morphology J:223082
mandible hypoplasia J:223082
polydactyly J:223082
short snout J:223082
Shhtm1Chg/Shhtm1Chg
Tg(Prrx1-Sox9,-lacZ)1Haak/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal limb bud morphology J:121946
Shhtm1Chg/Shhtm1Chg
Tmem107schlei/Tmem107schlei
involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J 		abnormal floor plate morphology J:186552
exencephaly J:186552
normal limbs/digits/tail phenotype J:186552
oligodactyly J:186552
Shhtm1Chg/Shhtm1Chg
Tulp3hhkr/Tulp3hhkr
involves: 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL/6 		abnormal neural tube morphology J:147584
edema J:147584
exencephaly J:147584
oligodactyly J:147584
spina bifida J:147584
Shhtm1Chg/Shhtm1Chg
Zic2Ku/Zic2Ku
involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH 		abnormal forebrain morphology J:138862
abnormal heart morphology J:138862
decreased embryo size J:138862
failure of initiation of embryo turning J:138862
Six3tm3.1Gco/Six3+
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cerebral hemisphere morphology J:140315
abnormal medial nasal prominence morphology J:140315
abnormal optic stalk morphology J:140315
abnormal palatal shelf fusion at midline J:140315
abnormal telencephalon morphology J:140315
absent corpus callosum J:140315
absent nasal septum J:140315
absent philtrum J:140315
holoprosencephaly J:140315
microcephaly J:140315
ocular hypotelorism J:140315
olfactory bulb hypoplasia J:140315
Sox9tm1Gsr/Sox9tm1Gsr
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129P2/OlaHsd 		abnormal branching involved in lung morphogenesis J:202984
abnormal cell differentiation J:202984
abnormal lung epithelium morphology J:202984
decreased cell migration J:202984
decreased cell proliferation J:202984
lung cyst J:202984
perinatal lethality, incomplete penetrance J:202984
postnatal lethality, complete penetrance J:202984
respiratory distress J:202984
small lung J:202984
Sp8tm1Smb/Sp8tm1Smb
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial development J:200761
normal craniofacial phenotype J:200761
ocular hypertelorism J:200761
Tctn1Gt(KST296)Byg/Tctn1Gt(KST296)Byg
Shhtm1Chg/Shhtm1Chg
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		increased forebrain size J:103820
Tg(UAS-Shh)1Rth/0
Tg(Wnt1-GAL4)1Rth/0
involves: C57BL/6J * CBA/J 		abnormal blood vessel morphology J:57948
abnormal epaxial muscle morphology J:57948
abnormal midbrain morphology J:57948
abnormal neurocranium morphology J:57948
abnormal spinal cord morphology J:57948
absent vertebral arch J:57948
hemorrhage J:57948
hydromyelia J:57948
increased cell proliferation J:57948
increased spinal cord size J:57948
midbrain hyperplasia J:57948
Wnt1tm1.1Mze/Wnt1tm1.1Mze
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S6/SvEvTac * C57BL/6N 		abnormal midbrain morphology J:194842
decreased neuron number J:194842
premature neuronal precursor differentiation J:194842
Yy1tm2.1Yshi/Yy1tm2.1Yshi
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S4/SvJae * C57BL/6J 		abnormal airway basal cell morphology J:239777
abnormal branching involved in lung morphogenesis J:239777
abnormal lung development J:239777
abnormal lung epithelium morphology J:239777
abnormal lung morphology J:239777
abnormal lung-associated mesenchyme development J:239777
abnormal respiratory epithelium physiology J:239777
abnormal trachea morphology J:239777
abnormal tracheal cartilage morphology J:239777
abnormal tracheal ciliated epithelium morphology J:239777
decreased club cell number J:239777
decreased respiratory mucosa goblet cell number J:239777
impaired myofibroblast differentiation J:239777
increased lung apoptosis J:239777
left pulmonary isomerism J:239777
lung cyst J:239777
neonatal lethality, complete penetrance J:239777
respiratory failure J:239777
trachea stenosis J:239777
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory