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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
MGI:98325
36 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hprt1tm1.1(CAG-Smpd1)Jhkh/Hprt1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal ceramide level J:199833
abnormal depression-related behavior J:199833
abnormal neuron differentiation J:199833
abnormal physiological response to xenobiotic J:199833
Smpd1tm1Esc/Smpd1+
involves: 129S1/Sv * C57BL/6J 		abnormal immune system cell morphology J:70489
Smpd1tm1Esc/Smpd1tm1Esc
involves: 129S1/Sv 		abnormal ceramide level J:199833
abnormal depression-related behavior J:199833
abnormal neuron differentiation J:199833
abnormal physiological response to xenobiotic J:199833
Smpd1tm1Esc/Smpd1tm1Esc
involves: 129S1/Sv * C57BL/6J 		abnormal apoptosis J:35076
abnormal granulocyte physiology J:81982
abnormal lipid homeostasis J:26732
abnormal male germ cell morphology J:78875
asthenozoospermia J:78875
ataxia J:26732
cerebellum atrophy J:26732
decreased body weight J:26732
decreased brain size J:26732
hunched posture J:26732
normal immune system phenotype J:44401
impaired sperm capacitation J:78875
increased circulating HDL cholesterol level J:26732
increased macrophage derived foam cell number J:81982
increased susceptibility to bacterial infection J:81982
lethargy J:26732
midbrain atrophy J:26732
premature death J:26732
Purkinje cell degeneration J:26732
normal reproductive system phenotype J:78875
teratozoospermia J:78875
tremors J:26732
Smpd1tm1Wst/Smpd1tm1Wst
involves: 129P2/OlaHsd * C57BL/6 		abnormal cerebral cortex morphology J:26748
abnormal choroid plexus morphology J:26748
abnormal lipid homeostasis J:26748
abnormal pulmonary alveolus morphology J:26748
ataxia J:26748
enlarged liver J:26748
enlarged spleen J:26748
gliosis J:26748
hepatosplenomegaly J:26748
impaired coordination J:26748
increased macrophage derived foam cell number J:26748
premature death J:26748
Purkinje cell degeneration J:26748
respiratory distress J:26748
tremors J:26748
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory