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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Snap25
synaptosomal-associated protein 25
MGI:98331
73 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Snap25Bdr/Snap25+
involves: BALB/cAnNCrl 		abnormal miniature excitatory postsynaptic currents J:119733
abnormal pancreatic beta cell physiology J:119733
ataxia J:119733
normal behavior/neurological phenotype J:119733
decreased glucagon secretion J:119733
decreased insulin secretion J:119733
decreased prepulse inhibition J:119733
decreased synaptic glutamate release J:119733
impaired coordination J:119733
normal taste/olfaction phenotype J:119733
Snap25Bdr/Snap25+
involves: BALB/cAnNCrl * C3H/HeN 		abnormal motor capabilities/coordination/movement J:63816
Snap25tm1.1Bark/Snap25tm1.1Bark
B6.Cg-Snap25tm1.1Bark 		abnormal hippocampus CA3 region morphology J:142096
abnormal spatial learning J:142096
decreased body weight J:142096
decreased locomotor activity J:142096
decreased paired-pulse facilitation J:142096
increased anxiety-related response J:142096
increased thigmotaxis J:142096
seizures J:142096
Snap25tm1.1Bark/Snap25tm1.1Bark
Not Specified 		abnormal insulin secretion J:226064
decreased circulating ghrelin level J:226064
decreased food intake J:226064
hepatic steatosis J:226064
hyperglycemia J:226064
improved glucose tolerance J:226064
increased body mass index J:226064
increased body weight J:226064
increased circulating cholesterol level J:226064
increased circulating insulin level J:226064
increased circulating leptin level J:226064
increased circulating triglyceride level J:226064
increased food intake J:226064
increased susceptibility to diet-induced obesity J:226064
increased white adipose tissue amount J:226064
increased white fat cell size J:226064
insulin resistance J:226064
Snap25tm1.1Hze/Snap25+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr 		no abnormal phenotype detected J:101977
Snap25tm1Bark/Snap25tm1Bark
B6.Cg-Snap25tm1Bark 		decreased body size J:142096
decreased body weight J:142096
decreased paired-pulse facilitation J:142096
decreased width of hypertrophic chondrocyte zone J:142096
delayed eyelid opening J:142096
hyperactivity J:142096
impaired hearing J:142096
seizures J:142096
tremors J:142096
Snap25tm1Mcw/Snap25+
B6N.Cg-Snap25tm1Mcw 		abnormal object recognition memory J:227349
Snap25tm1Mcw/Snap25tm1Mcw
involves: C57BL/6 		abnormal blood vessel morphology J:73755
abnormal brain morphology J:80415
abnormal cerebral cortex morphology J:80415
abnormal CNS synaptic transmission J:73755
abnormal endplate potential J:73755
abnormal intercostal muscle morphology J:73755
abnormal miniature excitatory postsynaptic currents J:73755
abnormal PNS synaptic transmission J:73755
abnormal skin condition J:73755
blotchy skin J:73755
decreased embryo size J:73755
neonatal lethality, complete penetrance J:73755
no spontaneous movement J:73755
respiratory failure J:73755
thin diaphragm muscle J:73755
unresponsive to tactile stimuli J:73755
Snap25tm1Mtaka/Snap25tm1Mtaka
B6N.129P2-Snap25tm1Mtaka 		abnormal dopamine level J:177870
abnormal impulsive behavior control J:177870
abnormal locomotor behavior J:177870
abnormal serotonin level J:177870
convulsive seizures J:177870
decreased vertical activity J:177870
increased anxiety-related response J:177870
increased locomotor activity J:177870
increased thigmotaxis J:177870
postnatal lethality, incomplete penetrance J:177870
Snap25tm2.1(cre)Hze/Snap25+
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr 		no abnormal phenotype detected J:146821
Snap25tm2Mcw/Snap25tm2Mcw
involves: C57BL/6J 		akinesia J:94005
decreased body weight J:94005
disheveled coat J:94005
enhanced paired-pulse facilitation J:94005
infertility J:94005
myoclonus J:94005
postnatal lethality, incomplete penetrance J:94005
premature death J:94005
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory