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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sod1
superoxide dismutase 1, soluble
MGI:98351
142 phenotypes from 9 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sod1m1H/Sod1+
involves: C3H/HeH * C57BL/6J 		abnormal locomotor activation J:219360
abnormal mitochondrial physiology J:219360
abnormal neuron physiology J:219360
decreased locomotor activity J:219360
Sod1m1H/Sod1m1H
involves: C3H/HeH * C57BL/6J 		abnormal body fat mass J:219360
abnormal corticospinal tract morphology J:219360
abnormal gait J:219360
abnormal liver morphology J:219360
abnormal motor neuron innervation pattern J:219360
abnormal muscle fiber morphology J:219360
astrocytosis J:219360
decreased body weight J:219360
decreased grip strength J:219360
decreased motor neuron number J:219360
hyporesponsive to tactile stimuli J:219360
impaired coordination J:219360
increased hepatocellular carcinoma incidence J:219360
increased liver tumor incidence J:219360
increased thermal nociceptive threshold J:219360
kyphosis J:219360
lethality, incomplete penetrance J:219360
liver inflammation J:219360
microgliosis J:219360
motor neuron degeneration J:219360
positive geotaxis J:219360
premature death J:219360
progressive muscle weakness J:219360
tremors J:219360
Sod1tm1Cep/Sod1+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal auditory brainstem response waveform shape J:118910
cochlear inner hair cell degeneration J:118910
cochlear outer hair cell degeneration J:118910
increased or absent threshold for auditory brainstem response J:118910
increased susceptibility to age-related hearing loss J:118910
Sod1tm1Cep/Sod1tm1Cep
involves: 129S1/Sv * 129X1/SvJ 		abnormal common lymphocyte progenitor cell morphology J:71134
decreased common myeloid progenitor cell number J:71134
decreased erythrocyte cell number J:71134
decreased hemoglobin content J:71134
hepatic steatosis J:71134
Sod1tm1Cep/Sod1tm1Cep
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal auditory brainstem response waveform shape J:118910
abnormal cochlear nerve morphology J:118910
cochlear ganglion degeneration J:118910
cochlear hair cell degeneration J:57435
cochlear inner hair cell degeneration J:57435, J:118910
cochlear outer hair cell degeneration J:57435, J:118910
increased or absent threshold for auditory brainstem response J:56971, J:118910
increased susceptibility to age-related hearing loss J:118910
increased susceptibility to noise-induced hearing loss J:56971
organ of Corti degeneration J:118910
pillar cell degeneration J:57435
Sod1tm1Cje/Sod1tm1Cje
involves: C57BL/6J * CD-1 		decreased fibroblast proliferation J:42265
increased fibroblast apoptosis J:42265
Sod1tm1Dkd/Sod1tm1Dkd
involves: 129S1/Sv * 129X1/SvJ 		abnormal cardiovascular system physiology J:60470
abnormal enzyme/coenzyme level J:60470
decreased cardiac muscle contractility J:60470
increased myocardial infarct size J:60470
myocardium necrosis J:60470, J:89952
oxidative stress J:60470
Sod1tm1Leb/Sod1+
B6;129S-Sod1tm1Leb/J 		cochlear ganglion degeneration J:102419
Sod1tm1Leb/Sod1tm1Leb
B6;129S-Sod1tm1Leb/J 		abnormal eye electrophysiology J:181434
abnormal retina ganglion layer morphology J:181434
abnormal retina nerve fiber layer morphology J:181434
cochlear ganglion degeneration J:102419
deafness J:102419
decreased retina ganglion cell number J:181434
increased or absent threshold for auditory brainstem response J:102419
thin stria vascularis J:102419
Sod1tm1Leb/Sod1tm1Leb
involves: 129S7/SvEvBrd * C57BL/6 		abnormal cornea epithelium morphology J:219024
abnormal Meibomian gland acinus morphology J:219024
abnormal Meibomian gland morphology J:219024
abnormal Meibomian gland physiology J:219024
abnormal mitochondrial morphology J:219024
abnormal ovary morphology J:64299
abnormal tear production J:219024
blepharitis J:219024
decreased circulating luteinizing hormone level J:64299
decreased corpora lutea number J:64299
decreased litter size J:64299
decreased mature ovarian follicle number J:64299
decreased tear production J:219024
dilated mitochondrion J:219024
disorganized mitochondrial cristae J:219024
female infertility J:64299
impaired ovarian folliculogenesis J:64299
increased circulating interleukin-6 level J:219024
increased circulating tumor necrosis factor level J:219024
increased interleukin-6 secretion J:219024
increased tumor necrosis factor secretion J:219024
Meibomian gland inflammation J:219024
oxidative stress J:219024
reduced female fertility J:64299
small ovary J:64299
suppressed circulating follicle stimulating hormone level J:64299
Sod1tm1Leb/Sod1tm1Leb
involves: 129S7/SvEvBrd-Hprtb-m2 * C57BL/6 		decreased a-wave amplitude J:134267
decreased b-wave amplitude J:134267
disorganized retina inner nuclear layer J:134267
disorganized retina outer nuclear layer J:134267
thin retina inner nuclear layer J:134267
thin retina outer nuclear layer J:134267
Sod1tm1Svb/Sod1tm1Svb
Tg(ACTA1-cre)79Jme/0
involves: C57BL/6J * SJL 		abnormal muscle physiology J:201098
abnormal muscle regeneration J:201098
normal behavior/neurological phenotype J:201098
centrally nucleated skeletal muscle fibers J:201098
normal homeostasis/metabolism phenotype J:201098
increased extensor digitorum longus weight J:201098
increased gastrocnemius weight J:201098
increased quadriceps weight J:201098
increased skeletal muscle mass J:201098
increased soleus weight J:201098
increased tibialis anterior weight J:201098
normal muscle phenotype J:201098
muscle weakness J:201098
normal nervous system phenotype J:201098
Sod1tm1Ysh/Sod1tm1Ysh
involves: 129X1/SvJ * C57BL/6 		decreased litter size J:46672
enhanced behavioral response to xenobiotic J:46672
increased susceptibility to xenobiotic induced morbidity/mortality J:46672
reduced female fertility J:46672
Tg(Sod1*G86R)M1Jwg/0
involves: C57BL/6 * FVB/N 		abnormal eye electrophysiology J:59356
paralysis J:59356
premature death J:59356
retina photoreceptor degeneration J:59356
short retina rod cell outer segment J:59356
thin retina outer nuclear layer J:59356
Tg(Sod1*G86R)M1Jwg/0
involves: FVB/N 		abnormal adipose tissue morphology J:91800
abnormal circulating hormone level J:91800
abnormal cranial nerve morphology J:22628
abnormal energy expenditure J:91800
abnormal facial motor nucleus morphology J:58733
abnormal fat pad morphology J:91800
abnormal gas homeostasis J:91800
abnormal glucose homeostasis J:91800
abnormal glycerol level J:91800
abnormal hypoglossal nucleus morphology J:58733
abnormal lipid homeostasis J:91800
abnormal motor capabilities/coordination/movement J:22628
abnormal muscle physiology J:91800
abnormal oculomotor nucleus morphology J:58733
abnormal spinal cord dorsal horn morphology J:22628
abnormal spinal cord ventral horn morphology J:22628
abnormal trigeminal motor nucleus morphology J:58733
aphagia J:22628
decreased body weight J:91800
decreased circulating insulin level J:91800
decreased circulating leptin level J:91800
decreased circulating triiodothyronine level J:91800
decreased grip strength J:131028
decreased respiratory quotient J:91800
decreased white adipose tissue amount J:91800
enhanced lipolysis J:91800
impaired adaptive thermogenesis J:91800
impaired balance J:131028
impaired coordination J:131028
increased circulating corticosterone level J:91800
increased circulating glucose level J:91800
increased circulating ketone body level J:91800
increased oxygen consumption J:91800
motor neuron degeneration J:22628
muscle degeneration J:22628
neurodegeneration J:22628
paralysis J:22628
premature death J:22628, J:91800
weakness J:22628
weight loss J:131028
Tg(SOD1*G86R)M3Jwg/0
involves: FVB/N 		abnormal motor capabilities/coordination/movement J:22628
abnormal spinal cord ventral horn morphology J:22628
aphagia J:22628
hindlimb paralysis J:22628
motor neuron degeneration J:22628
weakness J:22628
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory