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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sod2
superoxide dismutase 2, mitochondrial
MGI:98352
159 phenotypes from 6 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sod2tm1.1Kskk/Sod2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal myocardial fiber morphology J:98289
increased cardiomyocyte apoptosis J:98289
oxidative stress J:98289
Sod2tm1.1Kskk/Sod2tm1.1Kskk
involves: 129P2/OlaHsd * C57BL/6 		abnormal myocardial fiber morphology J:98289
fatigue J:98289
oxidative stress J:98289
postnatal growth retardation J:98289
postnatal lethality, complete penetrance J:98289
Sod2tm1Cje/Sod2+
B6.Cg-Sod2tm1Cje/Mmmh 		abnormal mitochondrial physiology J:108637
abnormal respiratory electron transport chain J:108637
increased lymphoma incidence J:87514
increased tumor incidence J:87514
normal mortality/aging J:87514
oxidative stress J:87514, J:108637
Sod2tm1Cje/Sod2+
D2.Cg-Sod2tm1Cje 		abnormal mitochondrial physiology J:73998
Sod2tm1Cje/Sod2+
involves: C57BL/6J * CD-1 		abnormal mitochondrial physiology J:67874
abnormal respiratory electron transport chain J:67874
increased hepatocyte apoptosis J:67874
oxidative stress J:67874
Sod2tm1Cje/Sod2+
involves: C57BL/6J * DBA/2J 		abnormal tricarboxylic acid cycle J:73998
Sod2tm1Cje/Sod2tm1Cje
B6.Cg-Sod2tm1Cje/Mmmh 		decreased fetal size J:73998
dilated cardiomyopathy J:73998
dilated heart left ventricle J:73998
dilated heart right ventricle J:73998
enlarged heart J:73998
lethality throughout fetal growth and development, incomplete penetrance J:73998
oxidative stress J:108637
perinatal lethality, complete penetrance J:73998
thin ventricular wall J:73998
Sod2tm1Cje/Sod2tm1Cje
D2.Cg-Sod2tm1Cje 		abnormal blood gas level J:73998
abnormal blood homeostasis J:73998
abnormal enzyme/coenzyme level J:73998
abnormal mitochondrial physiology J:73998
abnormal urine homeostasis J:73998
cardiac hypertrophy J:73998
decreased body weight J:73998
decreased circulating glucose level J:73998
hepatic steatosis J:73998
hyperoxia J:73998
hypocapnia J:73998
increased blood urea nitrogen level J:73998
increased circulating alkaline phosphatase level J:73998
increased circulating aspartate transaminase level J:73998
increased circulating ketone body level J:73998
increased heart weight J:73998
metabolic acidosis J:73998
postnatal lethality, complete penetrance J:73998
Sod2tm1Cje/Sod2tm1Cje
involves: C57BL/6J 		abnormal brainstem morphology J:45913
abnormal cerebellum morphology J:45913
abnormal cerebral cortex morphology J:45913
abnormal gait J:45913
abnormal optic nerve morphology J:71457
abnormal retina morphology J:71457
abnormal retina photoreceptor layer morphology J:71457
abnormal retina pigment epithelium morphology J:71457
ataxia J:45913
brain vacuoles J:45913
dilated cardiomyopathy J:45913
hepatic steatosis J:45913
impaired righting response J:45913
postnatal growth retardation J:45913
postnatal lethality, complete penetrance J:45913
spongiform encephalopathy J:45913
thin retina inner nuclear layer J:71457
tremors J:45913
Sod2tm1Cje/Sod2tm1Cje
involves: C57BL/6J * CD-1 		abnormal aerobic respiration J:52592
abnormal cell physiology J:52592
abnormal liver physiology J:29899
abnormal skeletal muscle morphology J:29899
abnormal tricarboxylic acid cycle J:29899, J:52592
calcinosis J:29899
cardiac fibrosis J:29899
cardiac hypertrophy J:29899
decreased body surface temperature J:29899
decreased circulating lactate level J:29899
decreased hematocrit J:29899
dilated cardiomyopathy J:29899
fatigue J:29899
hepatic steatosis J:29899
hypotonia J:29899
increased circulating ketone body level J:29899
increased liver weight J:29899
metabolic acidosis J:29899
organic aciduria J:52592
pallor J:29899
postnatal growth retardation J:29899
postnatal lethality, complete penetrance J:29899
Sod2tm1Cje/Sod2tm1Cje
involves: C57BL/6J * DBA/2J 		abnormal blood homeostasis J:73998
abnormal blood pH regulation J:73998
abnormal brain morphology J:98007
abnormal brainstem morphology J:98007
abnormal enzyme/coenzyme level J:73998
abnormal forebrain morphology J:98007
abnormal frontal lobe morphology J:98007
abnormal gait J:98007
abnormal hippocampus morphology J:98007
abnormal skeletal muscle fiber morphology J:98007
abnormal thalamus morphology J:98007
abnormal tricarboxylic acid cycle J:73998, J:98007
abnormal trigeminal motor nucleus morphology J:98007
abnormal trigeminal V mesencephalic nucleus morphology J:98007
abnormal urine homeostasis J:73998
acidosis J:73998
ataxia J:73998, J:98007
axon degeneration J:98007
cardiac hypertrophy J:73998
decreased body weight J:73998
decreased circulating glucose level J:73998
decreased skeletal muscle fiber size J:98007
hyperoxia J:73998
hypocapnia J:73998
increased blood urea nitrogen level J:73998
increased circulating ketone body level J:73998
increased heart weight J:73998
normal liver/biliary system phenotype J:73998
neuron degeneration J:98007
postnatal lethality, complete penetrance J:73998
seizures J:73998, J:98007
tremors J:98007
Sod2tm1Kskk/Sod2tm1Kskk
Tg(BEST1-rtTA,tetO-cre)1Yzl/0
B6.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl 		decreased a-wave amplitude J:282248
decreased b-wave amplitude J:282248
retina degeneration J:282248
retina pigment epithelium atrophy J:282248
thin retina outer nuclear layer J:282248
Sod2tm1Kskk/Sod2tm1Kskk
Tg(BEST1-rtTA,tetO-cre)1Yzl/0
B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl 		abnormal Bruch membrane morphology J:230153
abnormal cone electrophysiology J:230153
abnormal ocular fundus morphology J:230153
abnormal optic choroid morphology J:230153
abnormal retina photoreceptor layer morphology J:230153
abnormal retina pigment epithelium morphology J:230153
abnormal retina pigmentation J:230153
abnormal retina rod cell outer segment morphology J:230153
abnormal retina vasculature morphology J:230153
abnormal rod electrophysiology J:230153
oxidative stress J:230153
retina hemorrhage J:230153
retina photoreceptor degeneration J:230153
retina pigment epithelium atrophy J:230153
short photoreceptor inner segment J:230153
short photoreceptor outer segment J:230153
thin retina outer nuclear layer J:230153
Sod2tm1Leb/Sod2+
B6.129S7-Sod2tm1Leb/J 		normal hearing/vestibular/ear phenotype J:119972
Sod2tm1Leb/Sod2tm1Leb
B6.129S7-Sod2tm1Leb/J 		abnormal hepatocyte morphology J:36148
abnormal lipid homeostasis J:36148
abnormal mitochondrial physiology J:36148
abnormal motor capabilities/coordination/movement J:36148
anemia J:36148
circling J:36148
decreased body length J:36148
decreased body size J:36148
decreased body weight J:36148
decreased bone marrow cell number J:36148
decreased skeletal muscle mass J:36148
decreased total body fat amount J:36148
dilated cardiomyopathy J:36148
fatigue J:36148
impaired myelopoiesis J:36148
neurodegeneration J:36148
pallor J:36148
postnatal growth retardation J:36148
postnatal lethality, complete penetrance J:36148
normal reproductive system phenotype J:64299
thin ventricular wall J:36148
weakness J:36148
Sod2tm1Shs/Sod2+
Tg(Cdh16-cre)91Igr/0
involves: C57BL/6 * C57BL/6CrSlc 		abnormal renal tubule epithelium morphology J:174099
oxidative stress J:174099
Sod2tm1Shs/Sod2tm1Shs
involves: C57BL/6 * DBA 		normal liver/biliary system phenotype J:78889
Sod2tm1Shs/Sod2tm1Shs
Tg(CAG-cre)13Miya/0
involves: C57BL/6 * C57BL/6CrSlc 		perinatal lethality, complete penetrance J:78889
Sod2tm1Shs/Sod2tm1Shs
Tg(Cdh16-cre)91Igr/0
involves: C57BL/6 * C57BL/6CrSlc 		abnormal renal tubule epithelium morphology J:174099
normal cardiovascular system phenotype J:174099
decreased body weight J:174099
dilated distal convoluted tubule J:174099
normal homeostasis/metabolism phenotype J:174099
normal mortality/aging J:174099
oxidative stress J:174099
renal cast J:174099
normal renal/urinary system phenotype J:174099
Sod2tm1Shs/Sod2tm1Shs
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6CrSlc * FVB 		abnormal cardiac muscle tissue morphology J:117386
abnormal heart echocardiography feature J:117386
abnormal heart left ventricle morphology J:117386
abnormal mitochondrial ATP synthesis coupled electron transport J:117386
abnormal mitochondrial crista morphology J:117386
abnormal myocardium layer morphology J:117386
abnormal oxidative phosphorylation J:117386
abnormal skeletal muscle morphology J:117386
cardiac interstitial fibrosis J:117386
cardiac muscle necrosis J:117386
congestive heart failure J:117386
decreased body weight J:117386
decreased cardiac muscle contractility J:117386
decreased food intake J:117386
decreased locomotor activity J:117386
decreased mitochondrial size J:117386
dilated cardiomyopathy J:117386
dilated heart left ventricle J:117386
dilated heart ventricle J:117386
enlarged heart J:117386
fatigue J:117386
increased cardiac muscle glycogen level J:117386
increased heart weight J:117386
myocardial fiber degeneration J:117386
oxidative stress J:117386
postnatal growth retardation J:117386
premature death J:117386
Sod2tm1Shs/Sod2tm1Shs
Tg(Ckmm-cre)5Khn/0
involves: FVB 		abnormal enzyme/coenzyme activity J:171017
abnormal heart echocardiography feature J:171017
cardiac interstitial fibrosis J:171017
dilated cardiomyopathy J:171017
dilated heart J:171017
dilated heart left ventricle J:171017
increased heart weight J:171017
myocardial fiber degeneration J:171017
myocardial fiber disarray J:171017
oxidative stress J:171017
Sod2tm1Shs/Sod2tm1Shs
Tg(TNNI2-icre)1Vrmn/0
involves: C57BL/6 		abnormal enzyme/coenzyme activity J:155917
abnormal enzyme/coenzyme level J:155917
abnormal mitochondrial physiology J:155917
abnormal muscle contractility J:155917
abnormal muscle physiology J:155917
abnormal skeletal muscle fiber mitochondrial morphology J:155917
abnormal skeletal muscle morphology J:155917
abnormal tibialis anterior morphology J:155917
normal adipose tissue phenotype J:155917
decreased aerobic running capacity J:155917
normal growth/size/body region phenotype J:155917
normal homeostasis/metabolism phenotype J:155917
impaired exercise endurance J:155917
increased muscle cell glucose uptake J:155917
increased muscle fatigability J:155917
normal muscle phenotype J:155917
Sod2tm1Smel/Sod2tm1Smel
Tg(KRT14-cre/ERT)20Efu/0
involves: C57BL/6J * CD-1 		abnormal epidermis stratum corneum morphology J:226565
abnormal keratinocyte differentiation J:226565
abnormal mitochondrial ATP synthesis coupled electron transport J:226565
decreased epidermal stem cell number J:226565
decreased keratinocyte proliferation J:226565
delayed wound healing J:226565
early cellular replicative senescence J:226565
enhanced wound healing J:226565
skin lesions J:226565
thick epidermis J:226565
thin epidermis J:226565
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory