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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sod2
superoxide dismutase 2, mitochondrial
MGI:98352
24 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sod2tm1(rtTA*M2,tetO)Jsg/Sod2tm1(rtTA*M2,tetO)Jsg
involves: 129S6/SvEvTac * C57BL/6 		abnormal double-strand DNA break repair J:209713
abnormal redox activity J:209713
increased cell death J:209713
increased cellular sensitivity to gamma-irradiation J:209713
Sod2tm1(tetO-Sod2)Evbo/Sod2+
involves: 129S4/SvJae * C57BL/6 		abnormal heart left ventricle morphology J:162190
cardiac fibrosis J:162190
decreased heart left ventricle muscle contractility J:162190
increased cardiomyocyte apoptosis J:162190
increased myocardial fiber size J:162190
increased physiological sensitivity to xenobiotic J:162190
myocardium necrosis J:162190
Sod2tm1(tetO-Sod2)Evbo/Sod2tm1(tetO-Sod2)Evbo
involves: 129S4/SvJae * C57BL/6 		decreased body size J:162190
decreased locomotor activity J:162190
impaired balance J:162190
increased cardiomyocyte apoptosis J:162190
oxidative stress J:162190
postnatal lethality, complete penetrance J:162190
Sod2tm1Cje/Sod2+
Tg(SOD1*G93A)1Gur/0
involves: C57BL/6 * CD-1 * SJL 		abnormal motor neuron morphology J:62381
decreased neuron number J:62381
decreased spinal cord size J:62381
decreased spinal cord ventral horn cell number J:62381
decreased substantia nigra size J:62381
impaired coordination J:62381
premature death J:62381
Sod2tm1Cje/Sod2tm1Cje
SvtmsC57BL/6J/SvtmsC57BL/6J
involves: C57BL/6J * DBA/2J 		postnatal lethality, complete penetrance J:108213
Sod2tm1Cje/Sod2tm1Cje
SvtmsC57BL/6J/SvtmsDBA/2J
involves: C57BL/6J * DBA/2J 		normal mortality/aging J:108213
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory