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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
MGI:98354
64 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sos1tm1.1Les/Sos1tm1.1Les
Tg(Lck-cre)1Cwi/0
involves: 129 * C57BL/6 		decreased CD4-positive, alpha-beta T cell number J:174536
decreased CD8-positive, alpha-beta T cell number J:174536
decreased DN4 thymocyte number J:174536
decreased double-negative T cell number J:174536
decreased double-positive T cell number J:174536
decreased gamma-delta T cell number J:174536
decreased T cell proliferation J:174536
decreased thymocyte number J:174536
Sos1tm1.2Rak/Sos1+
involves: 129S/Sv * C57BL/6 * FVB/N * SJL 		abnormal cardiovascular system physiology J:171873
abnormal common myeloid progenitor cell morphology J:171873
abnormal craniofacial morphology J:171873
abnormal erythropoiesis J:171873
abnormal fetal cardiomyocyte proliferation J:171873
abnormal frontal bone morphology J:171873
abnormal heart left ventricle morphology J:171873
abnormal heart morphology J:171873
abnormal myocardial fiber morphology J:171873
aortic valve stenosis J:171873
cardiac fibrosis J:171873
cardiac interstitial fibrosis J:171873
normal cardiovascular system phenotype J:171873
decreased body length J:171873
decreased body size J:171873
decreased body weight J:171873
decreased cranium height J:171873
enlarged spleen J:171873
extramedullary hematopoiesis J:171873
heart left ventricle hypertrophy J:171873
hemorrhage J:171873
increased cardiomyocyte apoptosis J:171873
increased leukocyte cell number J:171873
increased megakaryocyte cell number J:171873
increased myocardial fiber size J:171873
increased neutrophil cell number J:171873
increased spleen red pulp amount J:171873
ocular hypertelorism J:171873
pericardial effusion J:171873
skin edema J:171873
thick aortic valve cusps J:171873
thick interventricular septum J:171873
Sos1tm1.2Rak/Sos1tm1.2Rak
involves: 129S/Sv * C57BL/6 * FVB/N * SJL 		abnormal cardiovascular system physiology J:171873
abnormal craniofacial morphology J:171873
abnormal fetal cardiomyocyte proliferation J:171873
abnormal frontal bone morphology J:171873
abnormal heart morphology J:171873
aortic valve stenosis J:171873
cardiac fibrosis J:171873
decreased body length J:171873
decreased body size J:171873
decreased body weight J:171873
decreased cranium height J:171873
embryonic lethality during organogenesis, incomplete penetrance J:171873
heart right ventricle hypertrophy J:171873
hemorrhage J:171873
lethality throughout fetal growth and development, incomplete penetrance J:171873
myocardial fiber degeneration J:171873
ocular hypertelorism J:171873
ostium secundum atrial septal defect J:171873
pericardial effusion J:171873
premature death J:171873
skin edema J:171873
thick aortic valve cusps J:171873
thick interventricular septum J:171873
ventricular septal defect J:171873
Sos1tm1Dlb/Sos1tm1Dlb
involves: 129S1/Sv * 129X1/SvJ 		abnormal blood vessel morphology J:38321
abnormal cardiovascular system morphology J:38321
abnormal heart atrium morphology J:38321
abnormal heart position or orientation J:38321
abnormal heart ventricle morphology J:38321
abnormal midbrain morphology J:38321
abnormal myocardial trabeculae morphology J:38321
blood vessel congestion J:38321
cleft palate J:38321
decreased embryo size J:38321
distended pericardium J:38321
enlarged heart J:38321
hemorrhage J:38321
pale yolk sac J:38321
prenatal lethality, complete penetrance J:38321
Sos1tm1Dlb/Sos1tm1Dlb
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal blood vessel morphology J:38321
abnormal heart atrium morphology J:38321
abnormal heart position or orientation J:38321
abnormal heart ventricle morphology J:38321
abnormal midbrain morphology J:38321
abnormal myocardial trabeculae morphology J:38321
blood vessel congestion J:38321
cleft palate J:38321
decreased embryo size J:38321
enlarged heart J:38321
enlarged pericardium J:38321
hemorrhage J:38321
pale yolk sac J:38321
prenatal lethality, complete penetrance J:38321
Sos1tm1Lowy/Sos1tm1Lowy
involves: 129S4/SvJae * C57BL/6N 		abnormal extraembryonic tissue morphology J:60649
embryonic lethality during organogenesis, complete penetrance J:60649
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory