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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox10
SRY (sex determining region Y)-box 10
MGI:98358
100 phenotypes from 14 alleles in 24 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sox10Dal/Sox10+
C57BL/6J-Sox10Dal 		variable body spotting J:132358
Sox10df8R/Sox10+
involves: 129X1/SvJ * C57BL/6J 		belly spot J:102039
Sox10Dom/Sox10+
C3Fe.B6JLe-Sox10Dom 		abnormal enteric ganglia morphology J:165146
abnormal enteric nervous system morphology J:165146
abnormal enteric neural crest cell morphology J:165146
abnormal neural crest cell physiology J:165146
Sox10Dom/Sox10+
C57BL/6J-Sox10Dom 		abnormal enteric ganglia morphology J:165146
abnormal enteric nervous system morphology J:165146
abnormal enteric neural crest cell morphology J:165146
abnormal neural crest cell physiology J:165146
aganglionic megacolon J:165146
Sox10Dom/Sox10+
involves: C3HeB/FeJLe * C57BL/6JLe 		abnormal enteric neuron morphology J:45117
abnormal neural crest cell migration J:45117
Sox10Dom/Sox10+
involves: C57BL/6JLe 		lethality at weaning, incomplete penetrance J:7688
megacolon J:7688
variable body spotting J:7688
Sox10Dom/Sox10+
Tg(DBHn-lacZ)8Rpk/0
involves: C3HeB/FeJLe * C57BL/6JLe * SJL 		abnormal colon morphology J:32868
abnormal intestine morphology J:32868
abnormal parasympathetic ganglion morphology J:32868
abnormal rectum morphology J:32868
abnormal vagal neural crest cell migration J:32868
white spotting J:32868
Sox10Dom/Sox10Dom
involves: C3HeB/FeJLe * C57BL/6JLe 		abnormal cranial ganglia morphology J:67383
abnormal dorsal root ganglion morphology J:67383
abnormal melanocyte differentiation J:45117
abnormal neural crest cell migration J:45117
abnormal nodose ganglion morphology J:67383
abnormal PNS glial cell morphology J:67383
abnormal Schwann cell morphology J:67383
abnormal sensory neuron morphology J:67383
abnormal spinal nerve morphology J:67383
abnormal superior cervical ganglion morphology J:67383
abnormal sympathetic ganglion morphology J:67383
abnormal ventral spinal root morphology J:67383
absent enteric neural crest cell J:67383
dorsal root ganglion degeneration J:67383
motor neuron degeneration J:67383
small dorsal root ganglion J:45117
Sox10Dom/Sox10Dom
involves: C57BL/6JLe 		embryonic lethality, complete penetrance J:7688
Sox10gt/Sox10+
GT/Le 		brain vacuoles J:216967
Sox10gt/Sox10+
involves: HYIII/LeJ 		spongiform encephalopathy J:7723
Sox10gt/Sox10gt
GT/Le 		belly spot J:216967
brain vacuoles J:216967
decreased foot pigmentation J:216967
diluted coat color J:216967
dysmyelination J:216967
gliosis J:216967
head blaze J:216967
megacolon J:216967
non-pigmented tail tip J:216967
premature death J:216967
spongiform encephalopathy J:216967
tremors J:216967
Sox10gt/Sox10gt
involves: C57BL/6 * GT/Le 		abnormal myelination J:216967
head blaze J:216967
premature death J:216967
seizures J:216967
Sox10gt/Sox10gt
involves: HYIII/LeJ 		abnormal digestive system physiology J:7723
absent skin pigmentation J:7723
belly spot J:7723
darkened coat color J:7723
demyelination J:7723
head blaze J:7723
premature death J:7723
spongiform encephalopathy J:7723
sporadic seizures J:7723
tremors J:7723
Sox10gt/Sox10tm1Weg
involves: 129S1/Sv * 129X1/SvJ * GT/Le 		absent coat pigmentation J:216967
brain vacuoles J:216967
decreased melanocyte number J:216967
megacolon J:216967
postnatal lethality, complete penetrance J:216967
Sox10M2Btlr/?
C57BL/6J-Sox10M2Btlr 		belly spot J:200817
decreased foot pigmentation J:200817
Sox10M2J/Sox10+
B6Ei.Cg-Sox10M2J/GrsrJ 		decreased foot pigmentation J:181083
decreased tail pigmentation J:181083
variable body spotting J:181083
Sox10tm1.1Sout/Sox10tm1.1Sout
involves: C57BL/6N 		no abnormal phenotype detected J:200671
Sox10tm1Ngan/Sox10+
involves: 129S/SvEv * C57BL/6 		dilated cochlea J:332093
Sox10tm1Ngan/Sox10tm1Ngan
involves: 129S/SvEv * C57BL/6 		dilated cochlea J:332093
Sox10tm1Weg/Sox10+
C3HeB/FeJ-Sox10tm1Weg 		aganglionic megacolon J:296651
belly spot J:296651
hypopigmentation J:296651
Sox10tm1Weg/Sox10+
involves: 129S1/Sv * 129X1/SvJ 		brain vacuoles J:216967
Sox10tm1Weg/Sox10+
involves: 129S1/Sv * 129X1/SvJ * C3H 		abnormal oligodendrocyte physiology J:260791
belly spot J:260791
megacolon J:260791
Sox10tm1Weg/Sox10+
involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J 		belly spot J:67383
decreased melanocyte number J:67383
megacolon J:67383
postnatal lethality, incomplete penetrance J:67383
Sox10tm1Weg/Sox10tm1Weg
involves: 129S1/Sv * 129X1/SvJ 		abnormal axon fasciculation J:203636
abnormal axon guidance J:203636
abnormal axon morphology J:203636
abnormal frontonasal mesenchyme morphology J:203636
abnormal glial cell morphology J:203636
abnormal olfactory bulb morphology J:203636
decreased cell migration J:203636
Sox10tm1Weg/Sox10tm1Weg
involves: 129S1/Sv * 129X1/SvJ * C3H 		abnormal oligodendrocyte physiology J:260791
absent Schwann cells J:260791
Sox10tm1Weg/Sox10tm1Weg
involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J 		abnormal dorsal root ganglion morphology J:67383
abnormal limb posture J:67383
abnormal melanoblast morphology J:67383
abnormal neural crest morphology J:67383
abnormal PNS glial cell morphology J:67383
cyanosis J:67383
decreased melanocyte number J:67383
perinatal lethality, incomplete penetrance J:67383
respiratory failure J:67383
unresponsive to tactile stimuli J:67383
Sox10tm2(rtTA)Weg/Sox10+
involves: 129P2/OlaHsd 		abnormal coat/hair pigmentation J:94207
belly spot J:94207
megacolon J:94207
Sox10tm2(rtTA)Weg/Sox10tm2(rtTA)Weg
involves: 129P2/OlaHsd 		perinatal lethality, complete penetrance J:94207
prenatal lethality, incomplete penetrance J:94207
Sox10tm3(Sox8)Weg/Sox10+
involves: 129P2/OlaHsd * FVB/N 		normal digestive/alimentary phenotype J:119015
Sox10tm3(Sox8)Weg/Sox10tm3(Sox8)Weg
involves: 129P2/OlaHsd * FVB/N 		abnormal enteric neural crest cell migration J:119015
abnormal enteric neuron morphology J:119015
abnormal melanoblast morphology J:119015
abnormal sympathetic ganglion morphology J:119015
absent coat pigmentation J:119015
absent hair follicle melanin granules J:119015
decreased oligodendrocyte number J:119015
increased vagal neural crest cell apoptosis J:119015
normal nervous system phenotype J:119015
postnatal growth retardation J:119015
postnatal lethality, complete penetrance J:119015
Sox10tm4Weg/Sox10+
involves: 129P2/OlaHsd * C3H 		belly spot J:124679
normal digestive/alimentary phenotype J:124679
Sox10tm4Weg/Sox10tm4Weg
involves: 129P2/OlaHsd * C3H 		abnormal enteric neuron morphology J:124679
abnormal melanoblast migration J:124679
abnormal Schwann cell morphology J:124679
aganglionic megacolon J:124679
dorsal root ganglion hypoplasia J:124679
neonatal lethality, incomplete penetrance J:124679
normal nervous system phenotype J:124679
postnatal lethality, complete penetrance J:124679
Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg
Tg(Dhh-cre)1Mejr/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL 		abnormal action potential J:162692
abnormal gait J:162692
abnormal limb posture J:162692
abnormal locomotor behavior J:162692
abnormal myelination J:162692
abnormal neuron proliferation J:162692
abnormal Schwann cell morphology J:162692
abnormal sciatic nerve morphology J:162692
decreased body weight J:162692
decreased nerve conduction velocity J:162692
impaired coordination J:162692
increased neuron apoptosis J:162692
postnatal growth retardation J:162692
premature death J:162692
tremors J:162692
Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg
Tg(Pou3f4-cre)32Cren/0
involves: 129P2/OlaHsd * CD-1 		decreased oligodendrocyte number J:324574
Sox10tm8.1Weg/Sox10+
involves: 129P2/OlaHsd * C3H 		abnormal oligodendrocyte physiology J:260791
belly spot J:260791
megacolon J:260791
Sox10tm8.1Weg/Sox10tm8.1Weg
involves: 129P2/OlaHsd * C3H 		abnormal nervous system morphology J:260791
abnormal oligodendrocyte physiology J:260791
abnormal Schwann cell physiology J:260791
decreased Schwann cell number J:260791
neonatal lethality, complete penetrance J:260791
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory