About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox10
SRY (sex determining region Y)-box 10
MGI:98358
100 phenotypes from 14 alleles in 24 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Sox10Dal/Sox10+
C57BL/6J-Sox10Dal 		variable body spotting J:132358
Sox10df8R/Sox10+
involves: 129X1/SvJ * C57BL/6J 		belly spot J:102039
Sox10Dom/Sox10+
C3Fe.B6JLe-Sox10Dom 		abnormal enteric ganglia morphology J:165146
abnormal enteric nervous system morphology J:165146
abnormal enteric neural crest cell morphology J:165146
abnormal neural crest cell physiology J:165146
Sox10Dom/Sox10+
C57BL/6J-Sox10Dom 		abnormal enteric ganglia morphology J:165146
abnormal enteric nervous system morphology J:165146
abnormal enteric neural crest cell morphology J:165146
abnormal neural crest cell physiology J:165146
aganglionic megacolon J:165146
Sox10Dom/Sox10+
involves: C3HeB/FeJLe * C57BL/6JLe 		abnormal enteric neuron morphology J:45117
abnormal neural crest cell migration J:45117
Sox10Dom/Sox10+
involves: C57BL/6JLe 		lethality at weaning, incomplete penetrance J:7688
megacolon J:7688
variable body spotting J:7688
Sox10Dom/Sox10+
Tg(DBHn-lacZ)8Rpk/0
involves: C3HeB/FeJLe * C57BL/6JLe * SJL 		abnormal colon morphology J:32868
abnormal intestine morphology J:32868
abnormal parasympathetic ganglion morphology J:32868
abnormal rectum morphology J:32868
abnormal vagal neural crest cell migration J:32868
white spotting J:32868
Sox10Dom/Sox10Dom
involves: C3HeB/FeJLe * C57BL/6JLe 		abnormal cranial ganglia morphology J:67383
abnormal dorsal root ganglion morphology J:67383
abnormal melanocyte differentiation J:45117
abnormal neural crest cell migration J:45117
abnormal nodose ganglion morphology J:67383
abnormal PNS glial cell morphology J:67383
abnormal Schwann cell morphology J:67383
abnormal sensory neuron morphology J:67383
abnormal spinal nerve morphology J:67383
abnormal superior cervical ganglion morphology J:67383
abnormal sympathetic ganglion morphology J:67383
abnormal ventral spinal root morphology J:67383
absent enteric neural crest cell J:67383
dorsal root ganglion degeneration J:67383
motor neuron degeneration J:67383
small dorsal root ganglion J:45117
Sox10Dom/Sox10Dom
involves: C57BL/6JLe 		embryonic lethality, complete penetrance J:7688
Sox10gt/Sox10+
GT/Le 		brain vacuoles J:216967
Sox10gt/Sox10+
involves: HYIII/LeJ 		spongiform encephalopathy J:7723
Sox10gt/Sox10gt
GT/Le 		belly spot J:216967
brain vacuoles J:216967
decreased foot pigmentation J:216967
diluted coat color J:216967
dysmyelination J:216967
gliosis J:216967
head blaze J:216967
megacolon J:216967
non-pigmented tail tip J:216967
premature death J:216967
spongiform encephalopathy J:216967
tremors J:216967
Sox10gt/Sox10gt
involves: C57BL/6 * GT/Le 		abnormal myelination J:216967
head blaze J:216967
premature death J:216967
seizures J:216967
Sox10gt/Sox10gt
involves: HYIII/LeJ 		abnormal digestive system physiology J:7723
absent skin pigmentation J:7723
belly spot J:7723
darkened coat color J:7723
demyelination J:7723
head blaze J:7723
premature death J:7723
spongiform encephalopathy J:7723
sporadic seizures J:7723
tremors J:7723
Sox10gt/Sox10tm1Weg
involves: 129S1/Sv * 129X1/SvJ * GT/Le 		absent coat pigmentation J:216967
brain vacuoles J:216967
decreased melanocyte number J:216967
megacolon J:216967
postnatal lethality, complete penetrance J:216967
Sox10M2Btlr/?
C57BL/6J-Sox10M2Btlr 		belly spot J:200817
decreased foot pigmentation J:200817
Sox10M2J/Sox10+
B6Ei.Cg-Sox10M2J/GrsrJ 		decreased foot pigmentation J:181083
decreased tail pigmentation J:181083
variable body spotting J:181083
Sox10tm1.1Sout/Sox10tm1.1Sout
involves: C57BL/6N 		no abnormal phenotype detected J:200671
Sox10tm1Ngan/Sox10+
involves: 129S/SvEv * C57BL/6 		dilated cochlea J:332093
Sox10tm1Ngan/Sox10tm1Ngan
involves: 129S/SvEv * C57BL/6 		dilated cochlea J:332093
Sox10tm1Weg/Sox10+
C3HeB/FeJ-Sox10tm1Weg 		aganglionic megacolon J:296651
belly spot J:296651
hypopigmentation J:296651
Sox10tm1Weg/Sox10+
involves: 129S1/Sv * 129X1/SvJ 		brain vacuoles J:216967
Sox10tm1Weg/Sox10+
involves: 129S1/Sv * 129X1/SvJ * C3H 		abnormal oligodendrocyte physiology J:260791
belly spot J:260791
megacolon J:260791
Sox10tm1Weg/Sox10+
involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J 		belly spot J:67383
decreased melanocyte number J:67383
megacolon J:67383
postnatal lethality, incomplete penetrance J:67383
Sox10tm1Weg/Sox10tm1Weg
involves: 129S1/Sv * 129X1/SvJ 		abnormal axon fasciculation J:203636
abnormal axon guidance J:203636
abnormal axon morphology J:203636
abnormal frontonasal mesenchyme morphology J:203636
abnormal glial cell morphology J:203636
abnormal olfactory bulb morphology J:203636
decreased cell migration J:203636
Sox10tm1Weg/Sox10tm1Weg
involves: 129S1/Sv * 129X1/SvJ * C3H 		abnormal oligodendrocyte physiology J:260791
absent Schwann cells J:260791
Sox10tm1Weg/Sox10tm1Weg
involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J 		abnormal dorsal root ganglion morphology J:67383
abnormal limb posture J:67383
abnormal melanoblast morphology J:67383
abnormal neural crest morphology J:67383
abnormal PNS glial cell morphology J:67383
cyanosis J:67383
decreased melanocyte number J:67383
perinatal lethality, incomplete penetrance J:67383
respiratory failure J:67383
unresponsive to tactile stimuli J:67383
Sox10tm2(rtTA)Weg/Sox10+
involves: 129P2/OlaHsd 		abnormal coat/hair pigmentation J:94207
belly spot J:94207
megacolon J:94207
Sox10tm2(rtTA)Weg/Sox10tm2(rtTA)Weg
involves: 129P2/OlaHsd 		perinatal lethality, complete penetrance J:94207
prenatal lethality, incomplete penetrance J:94207
Sox10tm3(Sox8)Weg/Sox10+
involves: 129P2/OlaHsd * FVB/N 		normal digestive/alimentary phenotype J:119015
Sox10tm3(Sox8)Weg/Sox10tm3(Sox8)Weg
involves: 129P2/OlaHsd * FVB/N 		abnormal enteric neural crest cell migration J:119015
abnormal enteric neuron morphology J:119015
abnormal melanoblast morphology J:119015
abnormal sympathetic ganglion morphology J:119015
absent coat pigmentation J:119015
absent hair follicle melanin granules J:119015
decreased oligodendrocyte number J:119015
increased vagal neural crest cell apoptosis J:119015
normal nervous system phenotype J:119015
postnatal growth retardation J:119015
postnatal lethality, complete penetrance J:119015
Sox10tm4Weg/Sox10+
involves: 129P2/OlaHsd * C3H 		belly spot J:124679
normal digestive/alimentary phenotype J:124679
Sox10tm4Weg/Sox10tm4Weg
involves: 129P2/OlaHsd * C3H 		abnormal enteric neuron morphology J:124679
abnormal melanoblast migration J:124679
abnormal Schwann cell morphology J:124679
aganglionic megacolon J:124679
dorsal root ganglion hypoplasia J:124679
neonatal lethality, incomplete penetrance J:124679
normal nervous system phenotype J:124679
postnatal lethality, complete penetrance J:124679
Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg
Tg(Dhh-cre)1Mejr/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL 		abnormal action potential J:162692
abnormal gait J:162692
abnormal limb posture J:162692
abnormal locomotor behavior J:162692
abnormal myelination J:162692
abnormal neuron proliferation J:162692
abnormal Schwann cell morphology J:162692
abnormal sciatic nerve morphology J:162692
decreased body weight J:162692
decreased nerve conduction velocity J:162692
impaired coordination J:162692
increased neuron apoptosis J:162692
postnatal growth retardation J:162692
premature death J:162692
tremors J:162692
Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg
Tg(Pou3f4-cre)32Cren/0
involves: 129P2/OlaHsd * CD-1 		decreased oligodendrocyte number J:324574
Sox10tm8.1Weg/Sox10+
involves: 129P2/OlaHsd * C3H 		abnormal oligodendrocyte physiology J:260791
belly spot J:260791
megacolon J:260791
Sox10tm8.1Weg/Sox10tm8.1Weg
involves: 129P2/OlaHsd * C3H 		abnormal nervous system morphology J:260791
abnormal oligodendrocyte physiology J:260791
abnormal Schwann cell physiology J:260791
decreased Schwann cell number J:260791
neonatal lethality, complete penetrance J:260791
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory