Sox11 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sox11
SRY (sex determining region Y)-box 11
MGI:98359

88 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(EIIa-cre)C5379Lmgd/0 involves: 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal craniofacial morphology	J:232434
	abnormal mandible morphology	J:232434
	abnormal palatal mesenchymal cell proliferation	J:232434
	abnormal secondary palate development	J:232434
	abnormal tongue position	J:232434
	cleft secondary palate	J:232434
	cleft upper lip	J:232434
	decreased palatal shelf size	J:232434
	delayed palatal shelf elevation	J:232434
	mandible hypoplasia	J:232434
	short mandible	J:232434
	small Meckel's cartilage	J:232434
Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(Six3-cre)69Frty/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2	abnormal axon fasciculation	J:199663
	abnormal eye development	J:199663
	abnormal retina bipolar cell morphology	J:199663
	abnormal retina morphology	J:199663
	decreased amacrine cell number	J:199663
	decreased birth weight	J:199663
	decreased retina ganglion cell number	J:199663
	increased retina apoptosis	J:199663
	optic nerve hypoplasia	J:199663
	thin retina ganglion layer	J:199663
	thin retina inner nuclear layer	J:199663
	normal vision/eye phenotype	J:199663
Sox11^tm1.1Llei/Sox11^tm1.1Llei involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:198233
Sox11^tm1.1Llei/Sox11^tm1.1Llei Tg(Nes-cre/ERT2)73Lfp/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal neuron differentiation	J:198233
	abnormal neuronal precursor proliferation	J:198233
Sox11^tm1.1Vlf/Sox11^tm1.1Vlf involves: 129 * C57BL/6	no abnormal phenotype detected	J:175338
Sox11^tm1.2Llei/Sox11^tm1.2Llei involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal cerebellum morphology	J:198233
	abnormal cerebral cortex morphology	J:198233
	abnormal cortical ventricular zone morphology	J:198233
	abnormal dentate gyrus morphology	J:198233
	abnormal embryonic/fetal subventricular zone morphology	J:198233
	abnormal hippocampus CA2 region morphology	J:198233
	abnormal hippocampus CA3 region morphology	J:198233
	abnormal hippocampus morphology	J:198233
	abnormal neuron differentiation	J:198233
	abnormal neuronal precursor proliferation	J:198233
	abnormal olfactory bulb morphology	J:198233
	decreased brain size	J:198233
	increased neuron apoptosis	J:198233
	neonatal lethality, complete penetrance	J:198233
	small cerebellum	J:198233
	small hippocampus	J:198233
	small olfactory bulb	J:198233
	thin cerebral cortex	J:198233
Sox11^tm1.2Vlf/Sox11^tm1.2Vlf involves: 129 * C57BL/6	abnormal bone mineralization	J:175338
	abnormal cranium morphology	J:175338
	abnormal heart development	J:175338
	abnormal lumbar vertebrae morphology	J:175338
	abnormal sternebra morphology	J:175338
	abnormal vertebrae morphology	J:175338
	abnormal xiphoid process morphology	J:175338
	absent spleen	J:175338
	cleft palate	J:175338
	cleft upper lip	J:175338
	double outlet right ventricle	J:175338
	eyelids open at birth	J:175338
	kinked tail	J:175338
	microphthalmia	J:175338
	omphalocele	J:175338
	perinatal lethality, complete penetrance	J:175338
	persistent truncus arteriosus	J:175338
	sternebra fusion	J:175338
	wide cranial sutures	J:175338
Sox11^tm1Weg/Sox11^tm1Weg involves: 129S1/Sv * 129X1/SvJ	abnormal bone ossification	J:92251
	abnormal bronchus morphology	J:92251
	abnormal calcaneum morphology	J:92251
	abnormal caudal vertebrae morphology	J:92251
	abnormal eyelid morphology	J:92251
	abnormal lumbar vertebrae morphology	J:92251
	abnormal pancreas morphology	J:92251
	abnormal phalanx morphology	J:92251
	abnormal pterygoid process morphology	J:92251
	abnormal rib morphology	J:92251
	abnormal sternebra morphology	J:92251
	abnormal sternum ossification	J:92251
	abnormal stomach pyloric region morphology	J:92251
	abnormal talus morphology	J:92251
	abnormal truncus arteriosus septation	J:92251
	absent spleen	J:92251
	asymmetric sternocostal joints	J:92251
	barrel chest	J:92251
	cleft upper lip	J:92251
	curly tail	J:92251
	cyanosis	J:92251
	decreased birth weight	J:92251
	decreased pulmonary respiratory rate	J:92251
	increased rib number	J:92251
	maxilla hypoplasia	J:92251
	median cleft palate	J:92251
	neonatal lethality, complete penetrance	J:92251
	omphalocele	J:92251
	palatal shelves fail to meet at midline	J:92251
	persistent truncus arteriosus	J:92251
	pulmonary hypoplasia	J:92251
	small stomach	J:92251
	ventricular septal defect	J:92251
Sox11^tm1Weg/Sox11^tm1Weg involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal nervous system development	J:157923
	abnormal sympathetic ganglion morphology	J:157923

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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