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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox2
SRY (sex determining region Y)-box 2
MGI:98364
125 phenotypes from 19 alleles in 21 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+
Tg(Sftpc-cre)1Blh/0
involves: 129S/SvEv * C57BL/6 * DBA/2 		abnormal lung morphology J:161806
bronchial epithelial hyperplasia J:161806
bronchiolar epithelial hyperplasia J:161806
increased lung adenocarcinoma incidence J:161806
lung epithelium hyperplasia J:161806
premature death J:161806
respiratory distress J:161806
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+
Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+
involves: 129S6/SvEv * C57BL/6 		bronchial epithelial hyperplasia J:161806
normal neoplasm J:161806
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh
Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+
involves: 129S6/SvEv * C57BL/6 		bronchial epithelial hyperplasia J:161806
increased lung adenocarcinoma incidence J:161806
Sox2em1(IMPC)Mbp/Sox2+
C57BL/6N-Sox2em1(IMPC)Mbp/MbpMmucd 		abnormal brain morphology J:211773
abnormal optic disk morphology J:211773
abnormal retina blood vessel morphology J:211773
abnormal retina vasculature morphology J:211773
embryonic growth retardation J:211773
enhanced contextual conditioning behavior J:211773
irregularly shaped pupil J:211773
Sox2em1(IMPC)Mbp/Sox2em1(IMPC)Mbp
C57BL/6N-Sox2em1(IMPC)Mbp/MbpMmucd 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Sox2tm1.1Knd/Sox2tm1.1Knd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal embryo phenotype J:217059
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Cryaa-cre)10Mlr/0
involves: C57BL/6 * FVB/N * SJL 		normal vision/eye phenotype J:152850
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Scgb1a1-cre)1Kkw/0
involves: 129/Sv * C57BL/6 		abnormal bronchiole epithelium morphology J:155963
abnormal lung epithelium morphology J:155963
abnormal respiratory mucosa goblet cell morphology J:155963
absent club cells J:155963
absent respiratory motile cilia J:155963
absent respiratory mucosa goblet cells J:155963
Sox2tm1.1Vep/Sox2+
Not Specified 		no abnormal phenotype detected J:99610
Sox2tm1.1Vep/Sox2tm1.2Vlcg
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac 		absent egg cylinders J:191980
absent embryonic epiblast J:191980
embryonic lethality between implantation and placentation, complete penetrance J:191980
increased trophoblast giant cell number J:191980
Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac 		normal behavior/neurological phenotype J:191980
normal growth/size/body region phenotype J:191980
Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac 		no abnormal phenotype detected J:200671
Sox2tm1.2Vlcg/Sox2+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac 		no abnormal phenotype detected J:191980
Sox2tm1.2Vlcg/Sox2tm1.2Vlcg
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac 		absent egg cylinders J:191980
absent embryonic epiblast J:191980
embryonic lethality between implantation and placentation, complete penetrance J:191980
increased trophoblast giant cell number J:191980
Sox2tm1Lpev/Sox2+
Not Specified 		no abnormal phenotype detected J:108452
Sox2tm1Lpev/Sox2tm2Lpev
involves: 129S/SvEv * C57BL/6 		abnormal digestive system physiology J:122531
abnormal esophageal squamous epithelium morphology J:122531
abnormal esophagus morphology J:122531
abnormal stomach morphology J:122531
esophageal atresia J:122531
neonatal lethality, complete penetrance J:122531
respiratory distress J:122531
tracheoesophageal fistula J:122531
Sox2tm1Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv 		abnormal eye size J:108452
Sox2tm1Lpev/Sox2tm3Lpev
involves: 129S/SvEv 		abnormal esophagus morphology J:112945
abnormal fungiform papillae morphology J:112945
abnormal stomach morphology J:112945
abnormal tongue morphology J:112945
absent palatal taste bud J:112945
anophthalmia J:108452
normal digestive/alimentary phenotype J:112945
disorganized retina layers J:108452
microphthalmia J:108452
neonatal lethality, complete penetrance J:112945
retina hyperplasia J:108452
Sox2tm1Lpev/Sox2tm4Lpev
involves: 129S/SvEv 		anophthalmia J:108452
disorganized retina layers J:108452
microphthalmia J:108452
optic nerve hypoplasia J:108452
retina hyperplasia J:108452
Sox2tm1Lpev/Sox2tm4Lpev
involves: 129S/SvEv * CD-1 		cleft secondary palate J:223203
delayed palatal shelf elevation J:223203
failure of palatal shelf elevation J:223203
microphthalmia J:223203
palatal shelves fail to meet at midline J:223203
Sox2tm1Okud/Sox2tm1Okud
Tg(Nes-cre)1Sasa/?
involves: 129P2/OlaHsd * C57BL/6 		abnormal neuronal precursor proliferation J:138323
enlarged lateral ventricles J:138323
neonatal lethality, complete penetrance J:138323
Sox2tm1Rlb/Sox2+
involves: 129S/SvEv 		reduced male fertility J:81180
Sox2tm1Rlb/Sox2+
involves: 129S/SvEv * MF1 		abnormal adenohypophysis development J:114458
abnormal pituitary gland morphology J:114458
abnormal seminiferous tubule morphology J:114458
bifurcated Rathke's pouch J:114458
decreased adrenocorticotropin level J:114458
decreased body size J:114458
decreased growth hormone level J:114458
decreased luteinizing hormone level J:114458
decreased prolactin level J:114458
decreased somatotroph cell number J:114458
decreased thyroid-stimulating hormone level J:114458
normal digestive/alimentary phenotype J:114458
oligozoospermia J:114458
postnatal lethality, incomplete penetrance J:114458
reduced male fertility J:81180, J:114458
small adenohypophysis J:114458
small testis J:114458
normal vision/eye phenotype J:114458
Sox2tm1Rlb/Sox2tm1Rlb
either: (involves: 129S/SvEv) or (involves: 129S/SvEv * MF1) 		abnormal ectoderm development J:81180
absent ectoplacental cone J:81180
absent egg cylinders J:81180
embryonic lethality between implantation and somite formation, complete penetrance J:81180
Sox2tm1Rlb/Sox2ysb
involves: 129S/SvEv * C57BL/6 * CBA 		abnormal semicircular canal morphology J:98458
abnormal sulcus ampullaris morphology J:98458
abnormal vestibular saccule morphology J:98458
circling J:98458
deafness J:98458
yellow coat color J:98458
Sox2tm1Vep/Sox2+
Not Specified 		no abnormal phenotype detected J:99610
Sox2tm2Lpev/Sox2+
involves: 129S/SvEv 		no abnormal phenotype detected J:108452
Sox2tm2Lpev/Sox2tm2.1Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv 		abnormal retina morphology J:108452
retina hypoplasia J:108452
Sox2tm2Lpev/Sox2tm2Lpev
involves: 129S/SvEv 		no abnormal phenotype detected J:108452
Sox2tm2Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv 		abnormal eye size J:108452
abnormal retina progenitor cell morphology J:108452
Sox2tm2Lpev/Sox2tm3Lpev
involves: 129S/SvEv * C57BL/6 		abnormal Ebner's gland morphology J:122531
abnormal epiglottis morphology J:122531
abnormal esophageal squamous epithelium morphology J:122531
abnormal esophagus morphology J:122531
abnormal salivary gland morphology J:122531
abnormal stomach morphology J:122531
absent anterior lingual gland J:122531
absent palatine gland J:122531
normal digestive/alimentary phenotype J:122531
neonatal lethality, complete penetrance J:122531
respiratory distress J:122531
normal respiratory system phenotype J:122531
Sox2tm2Skn/Sox2tm3Skn
involves: 129S/SvEv * 129S1/Sv * C57BL/6J 		abnormal brain morphology J:92063
abnormal cerebral cortex morphology J:92063
abnormal ependyma morphology J:92063
abnormal nervous system morphology J:92063
abnormal nervous system physiology J:92063
abnormal neuron differentiation J:92063
abnormal thalamus morphology J:92063
bidirectional circling J:92063
decreased body size J:92063
decreased corpus callosum size J:92063
dystonia J:92063
enlarged lateral ventricles J:92063
enlarged third ventricle J:92063
motor neuron degeneration J:92063
nonconvulsive seizures J:92063
premature death J:92063
prenatal lethality, incomplete penetrance J:92063
Sox2tm2Skn/Sox2tm4.1Skn
Tg(Nes-cre)1Kln/0
either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL) 		abnormal cerebral cortex morphology J:154650
abnormal corpus callosum morphology J:154650
abnormal dentate gyrus morphology J:154650
abnormal hippocampus development J:154650
abnormal neuron differentiation J:154650
absent dentate gyrus J:154650
enlarged lateral ventricles J:154650
loss of hippocampal neurons J:154650
premature death J:154650
small hippocampus J:154650
Sox2tm3Lpev/Sox2+
involves: 129S/SvEv 		no abnormal phenotype detected J:108452
Sox2tm3Lpev/Sox2tm3Lpev
involves: 129S/SvEv 		no abnormal phenotype detected J:108452
Sox2tm4.1Skn/Sox2tm4.1Skn
Tbx18tm2.1(cre)Sev/Tbx18+
involves: 129S1/Sv 		abnormal hair growth J:191082
normal integument phenotype J:191082
Sox2tm4.1Skn/Sox2tm4.1Skn
Tg(Sox2-cre/ERT2)1Skn/0
involves: 129S1/Sv * 129S4/SvJae 		abnormal neuron differentiation J:154650
abnormal neuronal precursor proliferation J:154650
abnormal radial glial cell morphology J:154650
Sox2tm4Lpev/Sox2+
involves: 129S/SvEv 		no abnormal phenotype detected J:108452
Sox2tm4Lpev/Sox2tm4Lpev
involves: 129S/SvEv 		no abnormal phenotype detected J:108452
Sox2ysb/Sox2+
involves: C57BL/6 * CBA 		yellow coat color J:77358
Sox2ysb/Sox2ysb
involves: C57BL/6 * CBA 		abnormal auchene hair morphology J:77358
abnormal awl hair morphology J:77358
abnormal cochlear hair cell morphology J:98458
abnormal inner ear morphology J:98458
abnormal pinna reflex J:77358
abnormal placing response J:77358
abnormal semicircular canal morphology J:98458
abnormal sulcus ampullaris morphology J:98458
abnormal zigzag hair morphology J:77358
absent vestibular hair cells J:98458
circling J:77358
deafness J:77358
decreased cochlea coiling J:98458
decreased cochlear nerve compound action potential J:77358
dilated cochlea J:98458
head tossing J:77358
impaired righting response J:77358
impaired swimming J:77358
yellow coat color J:77358
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory