Sox2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sox2
SRY (sex determining region Y)-box 2
MGI:98364

50 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Atg5^tm1.1Myok/Atg5^tm1.1Myok Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}/Col1a1⁺ involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N	abnormal cell physiology	J:205532
Cdk12^tm1.1Mjfn/Cdk12^tm1.2Mjfn Sox2^tm1Rlb/Sox2⁺ involves: 129S/SvEv * FVB/N	embryonic lethality between implantation and somite formation, complete penetrance	J:242195
Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}/Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae} Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} involves: 129S4/SvJae * C57BL/6	no abnormal phenotype detected	J:157298
Ctnnb1^tm1Mmt/Ctnnb1⁺ Sox2^{tm1.1(cre/ERT2)Jpmb}/Sox2⁺ involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	abnormal adenohypophysis morphology	J:201265
	increased pituitary gland tumor incidence	J:201265
Gas2^{tm1c(EUCOMM)Hmgu}/Gas2^{tm1c(EUCOMM)Hmgu} Sox2^{tm1(cre/ERT2)Hoch}/Sox2⁺ involves: 129S4/SvJae * C57BL/6 * C57BL/6N	abnormal distortion product otoacoustic emission	J:306028
	abnormal pillar cell morphology	J:306028
	impaired hearing	J:306028
	increased or absent threshold for auditory brainstem response	J:306028
Pax6^Sey-Neu/Pax6⁺ Sox2^tm1.1Vep/Sox2⁺ involves: 102 * C3H * C3H/HeN	abnormal lens morphology	J:119175
Pax6^tm2Pgr/Pax6^tm2Pgr Sox2^tm1.1Lan/Sox2^tm1.1Lan Tg(Cryaa-cre)10Mlr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL	abnormal lens epithelium morphology	J:152850
	increased lens epithelium apoptosis	J:152850
	microphthalmia	J:152850
Pou2f1^tm1Shrp/Pou2f1⁺ Sox2^tm1.1Vep/Sox2⁺ involves: 129S4/SvJae * C3H/HeN * C57BL/6	abnormal lens morphology	J:119175
Pou2f1^tm1Shrp/Pou2f1^tm1Shrp Sox2^tm1.1Vep/Sox2⁺ involves: 129S4/SvJae * C3H/HeN * C57BL/6	abnormal adenohypophysis morphology	J:119175
	abnormal eye development	J:119175
	abnormal lens induction	J:119175
	abnormal lens morphology	J:119175
	abnormal pituitary diverticulum morphology	J:119175
	absent nasal placodes	J:119175
	anophthalmia	J:119175
	microphthalmia	J:119175
Rb1^tm3Tyj/Rb1⁺ Sox2^tm4.1Skn/Sox2⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129 * C57BL/6 * CD-1	decreased osteosarcoma incidence	J:318885
	increased tumor-free survival time	J:318885
Rb1^tm3Tyj/Rb1⁺ Sox2^tm4.1Skn/Sox2^tm4.1Skn Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129 * C57BL/6 * CD-1	decreased osteosarcoma incidence	J:318885
	increased tumor-free survival time	J:318885
Sox1^tm1Vep/Sox1^tm1Vep Sox2^tm1Vep/Sox2⁺ involves: 129S/SvEv	abnormal olfactory cortex morphology	J:99610
Sox1^tm1Vep/Sox1^tm2Vep Sox2^tm1Vep/Sox2⁺ involves: 129S/SvEv	abnormal olfactory cortex morphology	J:99610
	microphthalmia	J:99610
	premature death	J:99610
	seizures	J:99610
Sox2^lcc/Sox2⁺ involves: 101/H * C3H/HeH	abnormal awl hair morphology	J:77358
	abnormal zigzag hair morphology	J:77358
	diluted coat color	J:77358
	head bobbing	J:77358
Sox2^lcc/Sox2^lcc involves: 101/H * C3H/HeH	abnormal awl hair morphology	J:77358
	abnormal guard hair morphology	J:77358
	abnormal inner ear morphology	J:98458
	abnormal semicircular canal morphology	J:98458
	abnormal sensory capabilities/reflexes/nociception	J:77358
	abnormal sulcus ampullaris morphology	J:98458
	abnormal zigzag hair morphology	J:77358
	absent cochlear hair cells	J:98458
	absent cochlear nerve compound action potential	J:77358
	circling	J:77358
	decreased cochlea coiling	J:98458
	head bobbing	J:77358
	small utricle	J:98458
	small vestibular saccule	J:98458
	yellow coat color	J:77358
Sox2^lcc/Sox2^tm1Rlb involves: 101/H * 129S/SvEv * C3H/HeH	abnormal semicircular canal morphology	J:98458
	abnormal sulcus ampullaris morphology	J:98458
	postnatal lethality	J:98458
	small utricle	J:98458
	small vestibular saccule	J:98458
Sox2^lcc/Sox2^ysb involves: 101/H * C3H/HeH * C57BL/6 * CBA	abnormal sensory capabilities/reflexes/nociception	J:77358
	absent cochlear nerve compound action potential	J:77358
	circling	J:77358
	head bobbing	J:77358
	yellow coat color	J:77358
Sox2^tm1.1Knd/Sox2^tm1.1Knd Tbx6^tm1Pa/Tbx6^tm1Pa involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal neural tube morphology	J:217059
Sox2^tm1.2Lan/Sox2^tm1.2Lan Tg(CAG-EGFP/Map1lc3b)53Nmz/0 involves: C57BL/6 * C57BL/6NCrlj * DBA/2 * FVB/N	abnormal autophagy	J:205532
Sox2^tm3(TK)Hoch/Sox2⁺ involves: 129S4/SvJae * C57BL/6	abnormal stomach morphology	J:177655
	decreased body size	J:177655
	decreased male germ cell number	J:177655
	edema	J:177655
	gastrointestinal ulcer	J:177655
	premature death	J:177655
	small testis	J:177655
	stomach inflammation	J:177655
	tongue inflammation	J:177655

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