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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox3
SRY (sex determining region Y)-box 3
MGI:98365
50 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sox3tm1.1Lja/Y
involves: 129S1/Sv * 129X1/SvJ 		abnormal seminiferous tubule morphology J:86431
abnormal Sertoli cell morphology J:86431
abnormal spermatogenesis J:86431
abnormal tooth morphology J:86431
normal behavior/neurological phenotype J:86431
decreased body weight J:86431
decreased germ cell number J:86431
decreased testis weight J:86431
oligozoospermia J:86431
Sox3tm1.1Lja/Sox3tm1.1Lja
involves: 129S1/Sv * 129X1/SvJ 		abnormal female reproductive system morphology J:86431
abnormal oocyte morphology J:86431
abnormal ovarian folliculogenesis J:86431
abnormal tooth morphology J:86431
normal behavior/neurological phenotype J:86431
decreased body weight J:86431
increased atretic ovarian follicle number J:86431
reduced female fertility J:86431
Sox3tm1Pqt/Y
chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal adenohypophysis development J:195300
abnormal pituitary infundibular stalk morphology J:195300
absent pituitary infundibular stalk J:195300
normal cellular phenotype J:195300
normal embryo phenotype J:195300
male infertility J:195300
Sox3tm1Rlb/Sox3+
involves: 129S7/SvEvBrd * MF1 		abnormal craniofacial morphology J:88507
Sox3tm1Rlb/Y
involves: 129S7/SvEvBrd * MF1 		abnormal brain commissure morphology J:88507
abnormal corpus callosum morphology J:88507
abnormal craniofacial morphology J:88507
abnormal diencephalon morphology J:88507
abnormal hippocampal commissure morphology J:88507
abnormal hypothalamus morphology J:88507
abnormal pituitary gland morphology J:88507
abnormal Rathke's pouch development J:88507
abnormal testis morphology J:88507
abnormal third ventricle morphology J:88507
bifurcated Rathke's pouch J:88507
decreased follicle stimulating hormone level J:88507
decreased growth hormone level J:88507
decreased thyroid-stimulating hormone level J:88507
postnatal growth retardation J:88507
postnatal lethality, incomplete penetrance J:88507
Sox3tm1Rlb/Sox3tm1Rlb
involves: 129S7/SvEvBrd * MF1 		abnormal brain commissure morphology J:88507
abnormal corpus callosum morphology J:88507
abnormal diencephalon morphology J:88507
abnormal hippocampal commissure morphology J:88507
abnormal hypothalamus morphology J:88507
abnormal pituitary gland morphology J:88507
abnormal Rathke's pouch development J:88507
abnormal third ventricle morphology J:88507
bifurcated Rathke's pouch J:88507
increased atretic ovarian follicle number J:88507
postnatal lethality J:88507
normal reproductive system phenotype J:88507
small ovary J:88507
Tg(Sox3)1Pqt/0
involves: C57BL/6 * CBA 		hydrocephaly J:184232
Tg(Sox3)1Pqt/0
Tg(Sox3-EGFP)NrPqt/0
involves: C57BL/6 * CBA 		abnormal diencephalon morphology J:184232
abnormal posterior commissure morphology J:184232
abnormal roof plate morphology J:184232
abnormal subcommissural organ morphology J:184232
absent pineal gland J:184232
absent pineal recess J:184232
domed cranium J:184232
enlarged lateral ventricles J:184232
enlarged third ventricle J:184232
hydrocephaly J:184232
increased cell proliferation J:184232
normal nervous system phenotype J:184232
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory